cryo-EM) is used extensively to determine structures of activated G protein-coupled receptors (GPCRs) in complex

adding odorant receptors, data mapper, structure similarity search and models of physiological ligand complexes adding odorant receptors, data mapper, structure similarity search and models of physiological ligand complexes

applicable to all proteins; it struggles with proteins that lack a clear function or perform multiple complex DMS with emerging sequencing technologies that allow for longer reads and more accurate mapping of complex

Although many cardiovascular GPCRs have been extensively studied as model receptors for decades, new complexities

In this review, we provide a systematic analysis of the currently available GPCR structures in complex

(June 4 - 8, 2023). 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

(June 4 - 8, 2023). 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

Upon agonist activation, the DOR-APEX2 complex is internalized and trafficked to the lysosome. APEX2 biosensor utilizes a fluorogenic substrate called Amplex UltraRed (AUR).

details of neuropeptide signaling and how it contributes to pathophysiology, which is likely due to complex

(June 4 - 8, 2023). 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

Thus, we need to know much more about the structures of receptor-ligand complexes at high resolution.

X-ray crystallographic structures of 2 in complex with two thermostabilized A2AAR constructs were solved

VLGR1 was previously found as membrane-membrane adhesion complexes and focal adhesions.

proteins that control the recruitment, activation, and scaffolding of numerous cytoplasmic signaling complexes

identification of patterns that characterize a functional state to contribute to the understanding of the complexity

This complexity makes it difficult to obtain a clear picture of TRPM3 characteristics.

proteins that control the recruitment, activation, and scaffolding of numerous cytoplasmic signaling complexes

The activation of mTOR complex 1 (mTORC1) is typically observed in human disease and continues to be

experiments are granted to evaluate these in silico predictions of the ADGRL3-GIP interaction and dissect the complexity

Hence, we performed extensive large-scale molecular dynamics (MD) simulations of the GPR97-Go complex

Final Symposium (August 31 - September 1, 2023) 3rd Transatlantic ECI GPCR Symposium (September 7 - 8,

(June 4 - 8, 2023). 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

The sheer complexity of the cell and the astonishing diversity of diseases are just two reasons why researchers

Polymerization of Dvl at the plasma membrane recruits the β-catenin destruction complex, enabling the

Here, we report the cryo-electron microscopy structures of GPR110 (ADGRF1), a member of aGPCR, in complex

A2BAR receptor labeling using live-imaging modalities, and displayed high efficiency when used to label complex

libraries have complementary advantages and illustrate how access to high-resolution structures of GPCRs in complex

bottom-line guidance Crinetics Pharmaceuticals to Report Second Quarter 2024 Financial Results on August 8,