This week's highlight includes congrats to: Junyi Liang, Niña Caculitan, and Adam W Smith for their research The workshop includes: 4x 2 hours live Zoom sessions (45-50 minutes lecture + 1-hour Q&A) Thirty minutes Hoare's workshop for individuals who live and work in developing countries. receptor Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects on mouse metabolism Mechanistic insights into sodium ion-mediated ligand binding affinity and

3 Pathfndr-2 Study In Acromegaly Patients GPCR Events, Meetings, and Webinars March 24 - 29, 2024 | Ligand

in brain intercellular signaling Are there sex differences in oxytocin and vasopressin V1a receptors ligand that is now part of Bristol Myers Squibb GPCR Events, Meetings, and Webinars March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

We are pleased to confirm the participation of a great lineup of speakers, namely Drs.  2024 GPCR Activation and Signaling Glu1022.53-Mediated Early Conformational Changes in the Process of Light-Induced Webinars March 13 - 15 | Biologics 2024 March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

Sandra Berndt, Ines Liebscher, and Susanne Horn et. al for their for their research on adhesion GPCR Hoare, you’ll learn how to analyze your data like a pro. Stay tuned for more information. Dr. receptors: from radioligand binding to cellular signaling GPR101: Modeling a constitutively active receptor linked to X-linked acrogigantism State-dependent dynamics of extramembrane domains in the β2 -adrenergic receptor Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

For example, the lipid composition of intracellular membranes may influence GPCR dynamics and signaling outcomes, changing the receptor conformation and accessibility to ligands2. signaling, GPCRs are also known to localize to the Golgi apparatus, where they can be activated by ligands receptor 5 (mGluR5), can lead to sustained calcium signaling and activation of transcription factors like This may involve the development of specialized delivery vehicles, such as nanoparticles or liposomes

Patrick Sexton, and Matthew Belousoff et al. for their work on Lipid-Dependent Activation of the Orphan We would like to extend our heartfelt thanks to Dr. We will be offering this live course again later this year. You'll share your contributor articles with the community, stay updated with GPCR literature, join a determines temperature acclimatization of Caenorhabditis elegan Species-Specific Duplicated FMRFaR-like

You can still join this waitlist and be the first to know when the live course is offered later this You'll share your contributor articles with the community, stay updated with GPCR literature, join a Drugs, and more Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand to specialize A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

Magdalena M Scharf, Antonella Di Pizio, Ines Liebscher, Hannes Schihada, and Gunnar Schulte et al. on We will be offering this live course later this year. You'll share your contributor articles with the community, stay updated with GPCR literature, network GPCRs in Cardiology, Endocrinology, and Taste G protein-coupled receptors driven intestinal glucagon-like Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

We are considering rerunning this live course later this year. You'll share your contributor articles with the community, stay updated with GPCR literature, join a signaling mediated by β-arrestins and its potential role in heart failure GPCRs in Neuroscience Role of lipids in Pharmacology and Drug Discovery March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

Take 2 minutes to fill out this survey and let us know what you liked, what you didn’t, and what we can analysis of Gi-coupling receptors via engineered Gt and Nb35 application Imaging GPCR Dimerization in Living in Pharmacology and Drug Discovery March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

If you'd like to join colleagues and Dr. The cost is USD $299 and includes: Four live Zoom sessions (1 hour lecture + 30 mins Q&A each) A 30-minute News Novartis Lutathera® significantly reduced risk of disease progression or death by 72% as first-line 2024 | 2024 BPS Annual Meeting NEW March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

GPCR University's live course with Dr. Terry Kenakin. The cost is $299 and includes: All 4 live Zoom sessions ( 4x 1 hour lecture + 30 mins Q&A) 30-minute functions as a feeding-state-dependent regulatory metabolite to counter pro-inflammatory signaling linked International Conference and Exhibition February 11 - 14, 2024 | 2024 BPS Annual Meeting March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

GPCR University's live Zoom sessions hosted by Dr. Terry Kenakin. The cost is $299 and includes: All 4 live Zoom sessions ( 4x 1 hour lecture + 30 mins Q&A) 30-minute adhesion G-protein-coupled receptor mayo/CG11318 controls midgut development in Drosophila Structure, ligands Annual Meeting March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

Heydenreich, Michel Bouvier, Brian Kobilka, M Madan Babu, and their team's work on Molecular determinants of ligand GPCR University's live Zoom sessions hosted by Dr. Terry Kenakin. The cost is $299 and includes: All 4 live Zoom sessions ( 4x 1 hour lecture + 30 mins Q&A) Complimentary immune response of Tribolium castaneum GPCR Activation and Signaling Palmitoylation of the Glucagon-like Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

Ross Cheloha's research involves semi-synthetic nanobody-ligand conjugates with enhanced transcriptional GPCR University's live Zoom sessions hosted by Dr. Terry Kenakin. The cost is $299 and includes: All 4 live Zoom sessions ( 4x 1 hour lecture + 30 mins Q&A) Complementary arcuate and rostral periventricular hypothalamic regions in female mice Cardiac optogenetics: shining light Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

GPCR University live Zoom sessions hosted by Dr. Terry Kenakin. GPCR Ecosystem members and non-members, with limited spots available for 20 attendees at USD 299. The package includes four live Zoom sessions, a one-year Dr. Annual Meeting March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

therapy Rational design of highly stabilized and selective adrenomedullin analogs Novel multi-target ligands scaffolds-synthesis, biological activity, and structural evaluation Flavonoids as G Protein-coupled Receptors Ligands cells through the enhancement of apoptosis Methods & Updates in GPCR Research Modulating signalling lifetime Annual Meeting March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

adhesion GPCR dissociation GPCR Activation and Signaling GPR101: Modeling a constitutively active receptor linked to X-linked acrogigantism The mechanism of Gαq regulation of PLCβ3-catalyzed PIP2 hydrolysis GPCR Binders receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand Annual Meeting March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

GPCR University live courses we are preparing for you in 2024. signaling via cAMP in parathyroid hormone (PTH) type 1 receptor biology β-arrestin1 is an E3 ubiquitin ligase adaptor for substrate linear polyubiquitination GPCR Binders, Drugs, and more Dual allosteric and orthosteric and Exhibition March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

You can find more details about the speakers on the Live Talks page, and make sure to mark your calendar in Cardiology, Endocrinology, and Taste Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like tissue morphogenesis TIPE proteins control directed migration of human T cells by directing GPCR and lipid Exhibition NEW March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

Find speaker details on the Live Talks page and mark your calendar HERE. exchange factor RIC-8 regulates cilia morphogenesis in Caenorhabditis elegans sensory neurons CaSR links Binders, Drugs, and more Cloning and deorphanization of three inotocin (insect oxytocin/vasopressin-like & Updates in GPCR Research Mining the ZINC database of natural products for specific, testosterone-like Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

Find speaker details on the Live Talks page and mark your calendar HERE. cell mobilization when combined with propranolol Discovery of 3-Phenyl Indazole-Based Novel Chemokine-like progress Industry News Anatole Klepatsky, Orion's COO, Shared Innovative Insights at LSBC Central European Life Meeting February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

Unlike orthosteric ligands that bind directly to the receptor's active site, allosteric modulators target functional and/or affinity for an orthosteric ligand; and negative allosteric modulators (NAMs), that fully or partially dampen the receptor's functional response to the ligand (Wold, Chen et al. 2019). Alternatively, they can function as neutral allosteric ligands (NALs), binding to a receptor's allosteric site without causing any detectable alterations in the receptor or orthosteric ligand behavior (Lindsley

You can find more information about them on the Live Talks page and mark your calendar HERE. β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor An siRNA library proliferation in white matter injury via Hedgehog-independent CREB signaling Ciliary localization of a light-activated Meeting February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

the Gαi3 heterotrimers Activation/Deactivation Free-Energy Profiles for the β2-Adrenergic Receptor: Ligand ascosporogenesis in the wheat scab fungus GPCR Binders, Drugs, and more Development of Photoswitchable Tethered Ligands Meeting February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

silico identification of a biarylamine acting as agonist at human β3 adrenoceptors and exerting BRL37344-like Endothelin-B receptor probes GPCRs in Cardiology, Endocrinology, and Taste GPRASP1 loss-of-function links malformations by endothelial activating GPR4 signals GPCRs in Neuroscience Involvement of a silkworm D2-like Meeting February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

by NMR spectroscopy with stable-isotope labeled receptors GPCR Binders, Drugs, and more Orthosteric ligand immunodeficiency G protein-coupled receptors: A target for microbial metabolites and a mechanistic link Meeting February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating