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intracellular protein complexes and solute carriers, are relevant to immunology indications and rare diseases

protein-coupled receptor (GPCR) kinases (GRKs) are associated with the pathophysiology of Alzheimer's disease

conformationally selective VHH antibodies – ConfoBodies® – to stabilize GPCRs (G protein-coupled receptors) in disease-relevant

modulator VU0486846 reduces neurogliosis in female Alzheimer's mice The association of GNB5 with Alzheimer disease of GPR139 in the medial septum ameliorates cognitive impairment in two mouse models of Alzheimer's disease

Morphine is one of the most widely used and proven analgesic for the treatment of severe acute or chronic Complex Persistent Opioid Dependence-an Opioid-induced Chronic Pain Syndrome.

sites of GPCRs for drug discovery Targeting mGluR group III for the treatment of neurodegenerative diseases Methods & Updates in GPCR Research Advancements in the use of xenopus oocytes for modelling neurological disease

Neisseria meningitidis is a Gram-negative opportunistic pathogen that is responsible for causing human diseases

GPCRs in Cardiology, Endocrinology, and Taste Gender Differences in GRK2 in Cardiovascular Diseases and Manager Director of Molecular Pharmacology, Discovery Biology Staff Scientist/Senior Staff Scientist, Disease

Retinitis pigmentosa (RP) is a group of hereditary degenerative diseases affecting 1 of 4000 people worldwide

Sir William Osler Scientists have long sought to discover a “golden bullet” that would cure every disease The more we know about the pathology of diseases, the more complicated it is to modulate them by a specific The choice of pathway can result in different cellular responses, underscoring the criticality of precise

numerous GPCRs have been studied for their impact on pathologic conditions, including cardiovascular diseases

Neuroscience Diverse signaling mechanisms and heterogeneity of astrocyte reactivity in Alzheimer's disease Sosei Heptares and Kallyope Nominate First GPCR Target for Therapeutic Development in Gastrointestinal Diseases

(GPCR) targets with a goal of creating new drug discovery programs in the area of gastrointestinal diseases

Several S1PR therapeutic drugs have been developed to treat these diseases; however, they lack receptor

effects of CB2 receptor activation, make this receptor an intriguing target for treating schizophrenia, a disease

phases of clinical development, and across multiple therapeutic areas, including Oncology, Infectious Diseases

Sosei Heptares’ world-leading StaR® (stabilized receptor) platform to generate novel antibody leads to disease-relevant

with the fact that dysregulation of compartmentalized GPCR signaling has been implicated in various diseases aberrant endosomal signaling by GPCRs has been linked to disorders such as cancer, neurodegenerative diseases Insights into Nuclear G-Protein-Coupled Receptors as Therapeutic Targets in Non-Communicable Diseases

dysfunction in the MOR-SNARE complex interaction can lead to various neurological disorders, such as chronic Struct. Mol. Biol. 15:658–664.

receptor type 9 (CCR9) antagonist and previous phase III clinical candidate for the treatment of Crohn's disease

protein-coupled receptors (aGPCRs) are keys of many physiological events and attractive targets for various diseases

fluorescent GPCR ligands "G-protein coupled receptors (GPCRs) have been largely targeted in a wide range of diseases

The mGlu5 receptor is a promising target for the treatment of psychiatric and neurodegenerative diseases

While these small protein GPCRs are valuable drug targets linked to serious diseases, many remain undrugged antagonist analogs have demonstrated powerful efficacies across a range of animal models spanning different disease Since many inflammatory diseases are driven by inappropriate recruitment of monocytes into tissues, CCR2 diversified portfolio of GPCR-targeted drug candidates for the treatment of cancer and other serious diseases Journal of Infectious Diseases, 199, 1525-1527. https://doi.org/10.1086/598685 · Demonstration

Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System, and Western Diseases concept to metabolomics: New insights into pregnenolone function Molecular characterization of lumpy skin disease

Please note that you will have to submit a 1-minute abstract video. Specialized Pro-resolving Lipid Mediators and Resolution of Viral Diseases.

September 2022 "G-protein-coupled receptors (GPCRs) are involved in a wide array of physiological and disease

GPCR Function Interplay of Cholesterol and Actin in Neurotransmitter GPCR Signaling: Insights from Chronic