Although PTHrP1-36 induces transient cAMP production, acute intracellular Ca2+ (iCa2+) release and β-arrestin

This may be broadly divided into studies focused on obtaining detailed molecular information in the intracellular

Similarly, in vitro calcium imaging showed that activation of the astrocytic Gi pathway attenuated intracellular

multiprotein GPCR superstructures, termed receptorsomes, both at the cell surface membrane and in the intracellular

Furthermore, after phosphorylating the C-terminal tail and intracellular loop 3 (ICL3) of NF-α1/CPE-5

respective domains in SoMam2 and SoMap3, which revealed differences between the receptors both in the intracellular

In the GI tract OR ligands drive an intracellular cascade that results in enhanced serotonin release In the human kidney ORs elicit intracellular Ca2+flux in renal proximal tubule cells via adenylyl cyclase

Mammalian type Opsin 5 preferentially activates G14 in Gq-type G proteins triggering intracellular calcium

Methods & Updates in GPCR Research Small Molecule Tools to Study Cellular Target Engagement for the Intracellular

The role of intracellular calcium and Rho kinase pathways in G protein-coupled receptor-mediated contractions

Methods & Updates in GPCR Research Fluorescent Ligands Enable Target Engagement Studies for the Intracellular

activation of the ERK MAPK by β-arrestin GPCR Binders, Drugs, and more Pharmacologically targeting intracellular

Class B1 GPCR activation by an intracellular agonist.

zebrafish Hrh2a histamine H2 receptor Revealing the graded activation mechanism of neurotensin receptor 1 Intracellular

GPCR Activation and Signaling Distinct beta-arrestin coupling and intracellular trafficking of metabotropic

GPCR Activation and Signaling Autoregulation of GPCR signalling through the third intracellular loop.

GPCR Activation and Signaling Ligand-dependent intracellular trafficking of the G protein-coupled P2Y6

Taste Single-cell transcriptomic atlas of enteroendocrine cells along the murine gastrointestinal tract Intracellular

New ligands and new GPCR behaviors that produce unique drug profiles (i.e. intracellular ligands and

Ligand-dependent intracellular trafficking of the G protein-coupled P2Y6 receptor.

the binding of agonists which stabilize receptor conformations that recruit and ultimately activate intracellular

Regulator G protein Signaling (RGS) proteins are critical components of the intracellular signaling pathways

These findings highlight how G proteins and β-arrestins are involved in driving intracellular signaling

engineering method using an amphiphilic polymer Labeling of CC Chemokine Receptor 2 with a Versatile Intracellular

PMID: 38311610 Member Dimitris Placantonakis’s identifies extended synaptotagmin 1 as an intracellular