He is the Research director at INSERM with a specific interest in G protein-coupled receptors by developing

Uppsala University in Sweden where he worked on the bioinformatic identification of 24 novel human G protein-coupled receptors.

development Published date June 14, 2024 Abstract "P2Y12 receptor (P2Y12R) is an adenosine-activated G protein-coupled receptor (GPCR) that plays a central role in platelet function, hemostasis, and thrombosis

rt1-bb1, Oprm1, Zfhx2, Gpr83, and Chrm2) were enriched in pathways related to inhibitory Gi-mediated G protein-coupled receptor (Gi-GPCR) neurons and neuropeptide changes. Progressive neuroinflammation spreads after injury, and neurotransmission through Gi-mediated G protein-coupled

Lab LinkedIn Characterization of Phenotypes Associated with GPR110 Deletion Hee-Yong Kim Abstract "G-protein Synaptamide, an endogenous ligand for GPR110, binds to the N-terminal G-protein autoproteolysis-inducing molecular basis for the renal phenotype, we analyzed in parallel differential expression of kidney proteins The change in protein expression of key proteins including VEGFA is associated with the abnormal renal

Cell Migration Published date June 25, 2023 Abstract "Bombesin receptor subtype-3 (BRS3) is an orphan G-protein Harvested cellular proteins were digested and phosphopeptides were enriched by immobilized titanium ( Data analysis revealed that 27 phosphopeptides corresponding to six proteins were involved in the Hippo by BRS3 activation could induce the dephosphorylation and nucleus localization of the Yes-associated protein

G-protein-coupled receptors (GPCRs) sense metabolites and can act as key mediators that translate gut

nanobody platform within the research group and used this platform to develop nanobodies targeting viral G protein-coupled receptors with a special focus on the human cytomegalovirus-encoded chemokine receptor in multiple projects where he focuses on the generation of nanobodies against "difficult-to-target" proteins

axis in signal transduction Published date September 1, 2023 Abstract "CCN1 and CCN2 are matricellular proteins CCN proteins act to facilitate signaling events involving extracellular matrix proteins. Lysophosphatidic acid (LPA) is a lipid that activates G protein-coupled receptors (GPCRs), enhancing Our group previously reported that LPA induces production of CCN1 protein in human prostate cancer cell There are multiple examples of the induction of CCN proteins by LPA, and by the related lipid mediator

identifying novel signal transduction mechanisms of GPCRs, such as the formation of complexes between G proteins and beta-arrestins.

Inflammatory Diseases Published date April 20, 2023 Abstract " The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a wide range of biological processes.

Deficiency of SCFA would lead to pro-inflammatory immune cell skewing through insufficient G-protein

human GPRC5D homodimer Published date June 19, 2024 Abstract "GPRC5D is an atypical Class C orphan G protein-coupled receptor.

receptors regulate a wide spectrum of endocrine tumors Published date September 23, 2024 Abstract "Aberrant G-protein

Date & Time Friday, November 3rd / 4:35 PM Abstract "Adenosine (ADO) signaling through A2A and A2B G protein-coupled receptors is increasingly recognized as an important immune checkpoint in the generation

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors

< GPCR News < GPCRs in Oncology and Immunology Autocrine proteinase-activated receptor signaling in PC3 prostate cancer cells Published date June 29, 2023 Abstract "Proteinase-activated receptors (PARs) are G protein-coupled receptors (GPCRs) activated by limited n-terminal proteolysis.

My project is investigating a new protein ligand for a GPCR and its potential role in obesity. During his graduate studies, Emile is interested in characterizing novel G protein-coupled receptors GPCR Title: Synapse-Associated Protein 102 and Post-Synaptic Density 95 Differentially Shape Dopamine About Bassam Albraidy "My thesis focus on studying the interaction of dopamine D1 receptors scaffolding proteins synapse-associated protein 102 and post-synaptic density 95, and the impact of these complexes in D1R-mediated

These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular The Beaulieu group is presently investigating how cell surface express proteins can act as allosteric These investigations have led to the identification of an RNA binding protein (FXR1P) involved in the regulation of protein synthesis as a potential downstream effector of the action of mood stabilizers

GPCR activation pathway Vaithish Velazhahan September 13, 2021 at 8:00:00 PM Learn More >> Heat Shock Protein Chris de Graaf September 14, 2021 at 12:00:00 PM Learn More >> Designer G protein-coupled receptors as September 16, 2021 at 12:00:00 PM Learn More >> Phosphorylation of the M1 muscarinic acetylcholine receptor protects Ajay Yekkirala September 16, 2021 at 2:00:00 PM Learn More >> Chaperoning G protein-coupled receptors

Published date March 1, 2024 Abstract "Vasoactive intestinal peptide (VIP) receptor 2 (VIPR2) is a G protein-coupled receptor that binds to Gαs, Gαi, and Gαq proteins to regulate various downstream signaling molecules, such as protein kinase A (PKA), phosphatidylinositol 3-kinase (PI3K), and phospholipase C

Neuropeptide Y (NPY) is an abundant neurohormone in human breast carcinomas that acts on a class of G-protein In human breast tumor tissue, we show via immunofluorescence that NPY5R protein levels and colocalization with hypoxia correlate with advanced cancer, and NPY1R protein correlates with adverse outcomes.

migration and autophagy of hepatocellular carcinoma cells in vitro Published date June 26, 2023 Abstract "G protein-coupled receptors (GPCRs) play important roles in tumorigenesis and the development of hepatocellular Previous studies have indicated that GPR50 could protect against breast cancer development and decrease

Here, we demonstrated that the neutrophil-expressed G-protein-coupled receptor (GPCR) Mrgpra1 is a negative

By combining experimental data with theory on leukocyte chemotaxis guided by the G protein-coupled receptor

fibroblast heterogeneity in fibroblast-associated diseases Published date August 1, 2023 Abstract "G protein-coupled receptors (GPCRs) are the largest and most diverse class of signaling receptors.

identifying novel signal transduction mechanisms of GPCRs, such as the formation of complexes between G proteins and beta-arrestins.

Here, we demonstrate that CB2, a G-protein-coupled receptor (GPCR) and member of the endocannabinoid Our results show that CB2 stimulation of ILC2s protects against insulin-resistance onset, ameliorates