In this institution dear to the heart of GPCR enthusiasts given that its faculty personnel included Dr

We focus on several aspects of metabolite-sensing GPCRs including signal transduction, intracellular Claudia suggested possible next steps, including researching review articles or articles to gain a higher

Particularly, we found that level of NF-κB p65 was increased in GPR97-/- DCs and BDP could inhibit p65

GPR50 expression was observed to be significantly increased in the adipose tissue of obese T2DM mice, while GPR50 deficiency increased inflammation in 3T3-L1 cells and induced the phosphorylation of AKT

2024 Abstract "G protein-coupled receptors (GPCRs) mediate a wide spectrum of physiological functions, including Multiple Wnt ligands were up- or downregulated in different cellular populations, including in non-osteoblastic

For the purposes of this presentation, I will walk you through my various career experiences and include

His major scientific contributions include the discovery that GPCRs are not only active at the plasma He has served on multiple panels and committees, including the ENDO Annual Meeting Steering Committee

an opportunity to tackle the challenge of identifying novel functional antibodies targeting GPCRs by incorporating

In recent years, investigators have described an increased rate of autoimmune comorbidities as evidenced

OGR1 (Gpr68) and GPR4 (Gpr4) are proton-activated G protein-coupled receptors that are stimulated upon increased To address this, we investigated their role in crystalline nephropathy by increasing the oxalate intake In this setting, OGR1 KO mice displayed an increased activation of the immune system and a higher production OGR1 deficiency, however, increases crystal deposition leading to impaired kidney function.

respond to clozapine, an hM3Dq agonist, unless they were preactivated by TCR and CD28 stimulation which increased

cancer is the second leading cause of cancer-related deaths globally, and its prevalence rates are increasing

protein-coupled receptor (GPCR) and plays important roles in various inflammatory diseases and cancers, including

Regulator of G protein signaling protein 6 (RGS6), identified as a tumor suppressor gene, has received increasing Moreover, AEC2s loss was significantly increased upon RGS6 knockout.

He has received many awards, including a Canada Research Chair, FRSQ scholarships and the CDA/CSEM/Merck

Slosky’s work has been recognized through several travel and research awards, including the William James Slosky is passionate about training the next generation of scientists and increasing diversity, equity , and inclusion in science.

mediated by carbohydrate and oxylipins, and clarified a comprehensive effect of fungal development, which include

However, a new study suggests that long-term use of P2Y12R inhibitors may increase the risk of cancer

To address the genetic heterogeneity of ovarian cancer, a future personalised approach could include

naïve MacGpr101KO mice displayed a marked shift in the expression of phenotypic and activation markers, including This was linked with an increased inflammatory response in the Gpr101 deficient animals and a reduced ability of phagocytes, including macrophages, to clear bacteria. mediator concentrations in Gpr101 deficient mice, with a downregulation of pro-resolving mediators including

transmitting signals inside the body, which is necessary for controlling the life activities of all cells, including

Examples include aberrant expression of MC2R, 5-HT4R, AVPR1A, LHCGR, and GnRHR in primary aldosteronism

assays demonstrated that RGS16 promoted the CRC progression, knockdown of RGS16 led to significantly increased

One-year cumulative incidence functions were calculated based on time to first respiratory infection were the most common site-specific infection and the relative proportion of respiratory infections increased

Scientific Journey and Drug Discovery Challenges Mike shared significant moments in his scientific journey, including

He then moved to work in the pharmaceutical industry where he has held positions of increasing responsibility

His academic background includes studies in mathematics, physics, and computer science at the French concluded with Yamina asking if Aurelien Rizk had a favorite GPCR to work on, though his response was not included Aurelien Rizk also mentioned the interdisciplinary nature of his company, which includes mathematics, They reminisced about previous meetings and events, including a GPCR retreat where Terry presented his

signaling to design/develop new pharmacotherapeutics to treat reward- and metabolism-based diseases, including