You can find more details about the speakers on the Live Talks page, and make sure to mark your calendar GPCR Activation and Signaling Neuronal survival factor TAFA2 suppresses apoptosis through binding to and activating cAMP/PKA/CREB/BCL2 signaling pathway Deciphering specificity and cross-reactivity in tachykinin Disorders at Jefferies Healthcare Conference in London Sosei Heptares and Kallyope Nominate First GPCR Target November 20 - 23, 2023 | ASCEPT Annual Scientific Meeting NEW January 16 - 19, 2024 | 23rd Annual PEP Talk

Take advantage of our GPCR highlights of the week. Dr. Find speaker details on the Live Talks page and mark your calendar HERE. neurons CaSR links endocytic and secretory pathways via MADD, a Rab11A effector that activates Rab27B Targeting effect of FDA approved purinergic receptor antagonist GPCRs in Cardiology, Endocrinology, and Taste Recent progress in degradation of membrane proteins by PROTACs and alternative targeted protein degradation

Find speaker details on the Live Talks page and mark your calendar HERE. Chemokine-like Receptor 1 Antagonists for the Treatment of Psoriasis GPCRs in Cardiology, Endocrinology, and Taste Conference and Exhibition June 2 - 7, 2024 | Chemotactic Cytokines GPCR Jobs NEW Staff Scientist (AC-TAP

You can find more information about them on the Live Talks page and mark your calendar HERE. Allosteric activation of the ERK MAPK by β-arrestin GPCR Binders, Drugs, and more Pharmacologically targeting intracellular allosteric sites of GPCRs for drug discovery Targeting mGluR group III for the treatment

wheat scab fungus GPCR Binders, Drugs, and more Development of Photoswitchable Tethered Ligands that Target

evaluation of novel fluorescent Endothelin-B receptor probes GPCRs in Cardiology, Endocrinology, and Taste receptor selectivity Industry News Sosei Heptares and Verily Nominate First G-protein-coupled receptor Target million to development of databases supporting medical research ‘Define your own success’: Duke leaders talk Secures Nearly $900K in NIH Funding to Discover Antibodies Against Difficult and Conserved Protein Targets GPCR Therapeutics Expands Pipeline into Fibrosis with a Combination Approach Targeting LPA1 GPCR Events

Did you know that as a premium member, you enjoy exclusive access to recorded talks from our Dr. Also, If you attended any of the talks, we'd truly value your feedback through our survey. predominant for gene expression regulation by β2-adrenergic receptor Allosteric modulation of the fish taste receptor HCAR2 Antipsychotic displays dual GPCR binding mode GPCRs in Cardiology, Endocrinology, and Taste Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting

Take a few minutes and dive into our GPCR coverage! Our recent Dr. If you couldn't make it, no sweat – our premium members can always go back and watch the recorded talks Short talk selections will be announced soon. Abstract submissions close on October 2nd. GPR61 acts by a G protein-competitive allosteric mechanism GPCRs in Cardiology, Endocrinology, and Taste Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting

Kevin Wright on his new position as Director of Targeted and Immuno-oncology at GPCR Therapeutics, our If you have registered, please submit poster abstracts through this form and the short talk selections Please take a look at the weekly Classified GPCR News from September 11th to 17th, 2023. Kevin Wright Joins GPCR Therapeutics as Director of Targeted and Immuno-oncology Sosei Heptares Adds Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting

Gregory Tall and team's study on GPR114/ADGRG5, activated by tethered-peptide-agonist, a cleaved adhesion Christopher Langmead and colleagues' work on the 5-HT2C receptor as a therapeutic target for substance Submit poster abstracts here; short talks will be selected from Abstracts. Exendin-P5 Biased Agonist Molecular and structural insights into the 5-HT2C receptor as a therapeutic target September 27 - 28, 2023 | Training Seminar "The Renaissance in GPCRs as Drug Targets: Allosteric Function

You can submit your poster abstracts using this form and short talks will be selected from abstracts. Binding Mode of the Alkyl Chain of Δ9-Tetrahydrocannabinol GPCRs in Cardiology, Endocrinology, and Taste Exempt from Transforming Growth Factor β-Mediated Antifibrotic G Protein-Coupled Receptor Landscape Tampering Deadline September 27, 2023 GPCR Events, Meetings, and Webinars September 25 - 28, 2023 | Discovery On Target September 27 - 28, 2023 | Training Seminar "The Renaissance in GPCRs as Drug Targets: Allosteric Function

Submit poster abstracts via this form; short talks will be selected. chemoattractant Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets Round to Fuel its Drug Discovery Engine and Pipeline of Small Molecule Therapeutics Reproducibility of Tanso September 7 - 8, 2023 | 3rd Transatlantic ECI GPCR Symposium September 25 - 28, 2023 | Discovery On Target September 27 - 28, 2023 | Training Seminar "The Renaissance in GPCRs as Drug Targets: Allosteric Function

Submit poster abstracts using this form; short talks will be selected from submissions. News from August 14 to 20, 2023 Adhesion GPCRs Amelioration of non-alcoholic fatty liver disease by targeting Methods & Updates in GPCR Research Magnetic Liposomes Infused with GPCR-Expressing Cell Membrane for Targeted August 31 - September 1, 2023) 3rd Transatlantic ECI GPCR Symposium (September 7 - 8, 2023) Discovery On Target - DOT (September 25 - 28, 2023) Training Seminar "The Renaissance in GPCRs as Drug Targets: Allosteric

detection, receptor activation initiates conformational changes, exposing an intracellular cavity (Kang Despite multifocal signaling, recent studies indicate that signaling occurs within a 100 nm range from high-resolution protein structures, illuminating side chain orientations and overall conformational states (Kang protein and has evolved to achieve resolutions comparable to X-ray crystallography (García-Nafría, J., & Tate Future perspectives In recent years, remarkable strides have been taken in unraveling the intricacies

Submit your abstracts for poster presentation using this form - short talks will be selected from these GPCR Activation and Signaling Tail engagement of arrestin at the glucagon receptor Gα protein signaling bias at 5-HT1A receptor GPCRs in Cardiology, Endocrinology, and Taste Gβγ-SNAP25 exocytotic brake removal NanoLuc as a new split technology with potential applications in chemical biology: a mini-review YAP/TAZ - DOT (September 25 - 28, 2023) Training Seminar "The Renaissance in GPCRs as Drug Targets: Allosteric

Nichola J Smith's investigation: Gene expression of TAS1R taste receptors for cardiometabolic disease Hematopoietic Stem/Progenitor Cells, in Mice and Healthy Subjects GPCRs in Cardiology, Endocrinology, and Taste Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease August 31 - September 1, 2023) 3rd Transatlantic ECI GPCR Symposium (September 7 - 8, 2023) Discovery On Target - DOT (September 25 - 28, 2023) Training Seminar "The Renaissance in GPCRs as Drug Targets: Allosteric

G protein-coupled receptor-mediated membrane targeting of PLCγ2 is essential for neutrophil chemotaxis GPCR Binders, Drugs, and more Development of a V5-tag-directed nanobody and its implementation as an GPCRs in Cardiology, Endocrinology, and Taste Insights on discovery, efficacy, safety and clinical applications - September 1, 2023) NEW 3rd Transatlantic ECI GPCR Symposium (September 7 - 8, 2023) Discovery On Target (September 25 - 28, 2023) ○ NEW Training Seminar "The Renaissance in GPCRs as Drug Targets: Allosteric

Premium members can always go back and watch the recorded talks at any time. GPCRs in Cardiology, Endocrinology, and Taste Cardiac contraction and relaxation are regulated by distinct Orion Biotechnology Completes Discovery of First-in-Class Molecule Against Undrugged GPCR Target in Four Months Cumulus Oncology and Leadxpro collaborate on small molecules targeting cancer-focused GPCR. Discovery On Target (September 25 - 28, 2023) 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023

GPCRs in Cardiology, Endocrinology, and Taste Clinical, Pathophysiologic, Genetic, and Therapeutic Progress Industry News Septerna Secures $150 Million in Series B Financing to Advance Pipeline of Novel GPCR-targeted NEW Discovery On Target (September 25 - 28, 2023) 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27,

Now, let's take a quick look at the Classified GPCR News from July 3rd to July 9th, 2023. GPCR targeting of E3 ubiquitin ligase MDM2 by inactive β-arrestin. GPCRs in Cardiology, Endocrinology, and Taste SOCS3 inhibits the mesenchymal stromal cell secretory factor

Let's take a quick look at the weekly Classified GPCR News from June 26th to July 2nd, 2023. GPCRs in Cardiology, Endocrinology, and Taste Adipocyte G Protein-Coupled Receptors as Potential Targets G protein-coupled receptor-targeting antibody-drug conjugates: Current status and future directions. History and function of the lactate receptor GPR81/HCAR1 in the brain: a putative therapeutic target G protein-coupled receptors as targets for transformative neuropsychiatric therapeutics.

on “Cell-based assays to study Adhesion GPCR function" (June 28 - 30, 2023) FREE Seminar Antibodies targeting

([6P4]CCL5), a chemokine antagonist ([5P7]CCL5), and a small-molecule inverse agonist (maraviroc) (Tan constitutive activity (Yen, Schafer et al. 2022) which is also supported by mutagenesis studies (Han, Tachado activation will pave the way for significant advancements in the development of therapeutics for a wide range

CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1 Signaling via RhoA. GPCRs in Neuroscience Orphan receptor GPR88 as a potential therapeutic target for CNS disorders - an Industry News Coherus to Acquire Surface Oncology Confo Therapeutics and AbCellera partner on GPCR-targeting (June 28 - 30, 2023) NEW FREE Seminar Antibodies targeting Membrane Proteins - From Antigen to New Therapeutics

GPCRs in Cardiology, Endocrinology, and Taste Discovery of paralogous GnRH and corazonin signaling systems Confo Therapeutics Enters Into Research Collaboration For GPCR-Targeting Antibody Discovery With AbCellera

Tagged for arrest: 'Barcode' determines receptor's fate. Our next Dr. We would also like to take a moment to thank the organizers for inviting Dr. GPCRs in Cardiology, Endocrinology, and Taste GPR97 deficiency ameliorates renal interstitial fibrosis Bitter Odorants and Odorous Bitters: Toxicity and Human TAS2R Targets. Targeting biased signaling by PAR1: function and molecular mechanism of parmodulins.

You can now watch the live talk recordings from the previous symposiums, check them out here. GPCRs in Cardiology, Endocrinology, and Taste Pathophysiology and pharmacology of G protein-coupled receptors

Although this study has limitations, such as the absence of the flexible distal C-tail of βArr2 in the Cell, 185(24), 4560–4573.e19. https://doi.org/10.1016/j.cell.2022.10.018 Latorraca, N.R., Wang, J.K.,