SARS-CoV-2 has now become the main trigger for ME/CFS. We have already conducted two small proof-of-concept studies on IgG depletion by immunoadsorption (IA

Her subsequent work has focused on understanding the role of compartmentalized Gq signaling by the cytomegalovirus-encoded

He has supervised the research work of 75 graduate students and 40 post-doctoral fellows.

Our laboratory has a long-standing interest in the way that NMDA receptors contribute to the symptoms Recently, we have focused our efforts on GRIN disorder. Our laboratory is working to help patients by developing genetically-modified mice that have disease-causing

Abstract Only Available for AGPCR24 Attendees About Jin-Peng Sun "Since starting my laboratory in 2011, I has We have identified the receptor subfamily to sense the steroid hormones. We have elucidated the mechanism of receptors' perception of itch, olfactory and force (Nature 2021b, For arrestin mediated biased signaling, we have proposed the “flute model” and “poly proline region docking We have decoded the mechanisms underlying recognition of fish oil (unsaturated fatty acids) and other

Although leukotriene B4 receptor 2 (BLT2) has been characterized as a low affinity receptor to several the applicability of our zebrafish findings to mammals by showing that macrophages of Ltb4r2-/- mice have

It is commonly assumed that one must have a thorough characterization of the network readily available analysis uncovers a role for co-occurring mutations involving the plexin/semaphorin pathway, which has

Conclusions: Antagonizing the NPYRs has been implicated as a treatment for a wide variety of diseases

More recently, I have shifted my focus to identifying allosteric modulators of host G-protein-coupled Traditional drug discovery efforts have focused on agonists and antagonists that bind to the orthosteric However, the pursuit of allosteric modulators has gained attention as they have the potential to fine-tune

failure Published date June 12, 2023 Abstract "Immune checkpoint blockade (ICB) targeting PD-1 and CTLA-4 has Francesco Raimondi , Thomas S Hoang , Rebecca Berdeaux , Dario A A Vignali , Ramiro Iglesias-Bartolome , Hannah

Although G protein-coupled receptors (GPCRs) are among the targets of current antifibrotic drugs, no drug has

June 14, 2024 Abstract " Purpose: The inherent genetic heterogeneity of acute myeloid leukemia (AML) has Timothy J Martins, Brenda Loera, Quy H Nguyen, Melanie L Oakes, Bahar Tercan, Boris Aguilar, Lauren Hagen

Consistent with its high specificity and stability, LP2 has shown excellent safety and pharmacokinetics

Besides regulating mood, appetite, and reproductive behavior, it has been identified as a potential target This study shows that cancer-associated mutations of 5-HT2C receptor have diverse effects on ligand binding

The participation of circular RNAs (circRNAs) in DPSC differentiation has been identified.

GPR15 is a G protein-coupled receptor (GPCR) located on chromosome 3 and has similarity in its sequence Our results suggest that GPR15/GPR15L have a pathogenic role in RA and their antagonizing could be a

Brentuximab vedotin (BV), an anti-CD30 monoclonal antibody linked to a microtubule-disrupting agent, has Results: Chidamide (tucidinostat), a novel histone deacetylase inhibitor, was found to have the greatest

recipients Published date May 30, 2023 Abstract "Post-transplant human cytomegalovirus (HCMV) viremia has

Increased VIPR2 mRNA expression and/or VIPR2 gene copy number has been documented in several cancers to an exacerbation of breast carcinoma. ” Authors Satoshi Asano , Ami Ono , Kotaro Sakamoto , Atsuko Hayata-Takano , Takanobu Nakazawa , Kotaro Tanimoto , Hitoshi Hashimoto , Yukio Ago Tags Breast cancer , Cell proliferation

Previous studies have identified the pivotal role of Lysophosphatidic acid (LPA)-signaling in ovarian Authors Ji Hee Ha , Rangasudhagar Radhakrishnan , Revathy Nadhan , Rohini Gomathinayagam , Muralidharan

The Wnt signaling pathway has been implicated in the pathogenesis of FD-like bone, but the specific Wnts

SRP gene expression has been also demonstrated to be enhanced by GBP, indicating that both cytokines Although GBP1 (CG15917) and GBP2 (CG11395) have been identified in Drosophila melanogaster, immunological functions have only been characterized for GBP1. Ono , Takashi Matsumura , Eui Jae Sung , Takashi Koyama , Masanori Ochiai , Stephen B Shears , Yoichi Hayakawa

Authors Shaohan Ma, Ruyue Li, Guangqi Li, Meng Wei, Bowei Li, Yongmei Li, Chunfang Ha Tags G protein-coupled

He has supervised the research work of 75 graduate students and 40 post-doctoral fellows. with some of his postdocs and although I was never officially a member of the lab, I am humbled to have

of adhesion GPCR Signaling and Pharmacology-Enabling Drug Discovery Laurent Sabbagh Characterizing hADGRE5 The NRS system has recently been validated in vivo by targeting the latrophilin-type aGPCR Cirl/ADGRL The platform has been successfully used internally to identify biased small molecule negative allosteric Laurent Sabbagh on the web Domain Therapeutics Characterizing hADGRE5/CD97 Activation and Signaling:

Slosky’s work has been recognized through several travel and research awards, including the William James Psychology Award, the Hank Yamamura Endowed Fellowship in Pharmacology, an NIH F32 Postdoctoral Fellowship

Van Meir has developed novel therapeutic approaches for cancer using oncolytic adenoviruses and anti-angiogenic ADGRG6 NTF has multiple extracellular domains like CUB, PTX, SEA, hormone binding domain, and the GAIN Stehlik et al. have reported that ADGRG6 expressed in lipopolysaccharide stimulated human umbilical vein demonstrate that specific N-glycan residues in different domains of the extracellular NTF of ADGRG6 have

He has been also studying what aspects of GPCR signaling are regulated in a sex-selective manner and