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Flowcytometry and Transwell assays were performed to observe the changes in cell apoptosis, metastasis via the signaling pathway of miR-19a/GRK6/GPR39/PKC, which accordingly resulted in suppressed cell apoptosis

Stimulation of GAL2 receptor may modulate immune surveillance and inhibits PDAC via cell cycle inhibition and apoptosis proteins may enhance immune surveillance, prevent carcinogenesis, counter proliferation and stimulate apoptosis

plausibly associated with GPR56 activity, we have constructed a signaling pathway map of GPR56 as may be applicable

Using complimentary cellular and biochemical approaches, proteins were tested for effects on GPCR-G α

Dasatinib-induced ERK activation was completely abolished by exposure to the FDA-approved MEK inhibitor The results provide rationale for considering a combination(s) of FDA-approved SFK (dasatinib) and MEK

She was able to have several grants approved in Brazil and abroad, which have granted her research group

GPCR-lncRNA-miRNA Nexus: Identification of an Aberrant Therapeutic Target in Ovarian Cancer Published date April

the poor pharmacokinetics and physicochemical properties of GPCR ligands greatly limit their clinical applicability nanotechnology for understanding their mutual influences and utilizing their interplay for biomedical applications Nanotechnology has also been applied to construct synthetic nano-GPCRs or detect GPCRs, while endosomal the designated value of GPCRs for molecular engineering of biomaterials with GPCRs in therapeutical application

annual percentage change (EAPC) with 95 % confidence intervals (95 % CI) fitted age-period-cohort (APC

GPR56CD-KO mice were born at predicted Mendelian frequencies, appeared grossly indistinguishable from Ligand binding and mechanical force applied on the ECR regulate receptor function.

The functional relevance of C5aR2 appears to be context-dependent compared to the C5aR1, which has received

My expertise includes biochemical approaches, proteomics and transcriptomics to name a few.

She held faculty appointments at the University of Illinois at Chicago School of Medicine and Northwestern

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Associations with cardiac markers, histology, and function in human non-ischaemic heart failure Published date April

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link between microbial regulation of ISCs and colitis exacerbation and yielding a targeted therapeutic approach

The implications of these findings for transforming the therapeutic approaches to renal complications

Pharmacological inhibition of the lipid synthesis pathway by statins is a therapeutic approach to control

Using the siRNA-mediated knockdown approach, we showed that the stimulatory effect of NPFF on MMP-9 expression

Immunology The β2-adrenergic receptor associates with CXCR4 multimers in human cancer cells Published date April

In this study, a quantitative phosphoproteomics approach was employed to comprehensively decipher the

Van Meir has developed novel therapeutic approaches for cancer using oncolytic adenoviruses and anti-angiogenic To address these gaps in knowledge, we used biochemical and cell-biological approaches using cell-lines

Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases Published date April To date, there are no drugs against CCR6 approved, and the development of small molecules against CCR6

Western blotting and flow cytometry were used to evaluate apoptosis and reactive oxygen species (ROS) decreased ROS production as well as proinflammatory factor transcription in macrophages and decreased apoptosis Chen , Jian Zhou , Linlin Wang , Yu Yan , Jun She , Lin Tong , Yuanlin Song Tags Acute lung injury , Apoptosis

autonomic pathologies in type 2 inflammatory diseases and present recent advances in targeted treatment approaches

regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation Published date April

., to adaptively initiate an apoptosis, inflammasome, Nrf2-ARE anti-oxidant, or heat-shock activation