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In this ECR-mediated mechanism of activation, the ECR-7TM communication is altered by transient interactions

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Hsi-Hsien Lin as summer intern twice, and finally joined the lab of Prof. Engel. receptors, which exhibit large multi-domain extracellular N-termini that mediate cell-cell and cell-matrix interactions kidney-specific Adgrf5/Gpr116 knockout causes luminal membrane accumulation of V-ATPase in acid-secreting A-type intercalated