We sat down to chat about GPCRs, synthesizing labeled ligands, and her unique position that allows her to work with GPCR scientists on 2 continents. We also touched on how COVID-19 affected her Ph.D. work. Eleonora Comeo on the web LinkedIn ResearchGate Pubmed Google Scholar Dr. Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

Revealing the critical pathogenic factors of CRC and the underlying mechanisms would offer potential G protein signaling (RGS) protein family modulators play essential role within regulating downstream We confirmed the elevated RGS16 protein level in CRC, and found that patients with RGS16-high tumors Notably, we also confirmed these phenotypes of RGS16 in organoids originated from resected primary human GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

We focus on several aspects of metabolite-sensing GPCRs including signal transduction, intracellular Quick recap Yamina and Claudia had a wide-ranging discussion about Claudia's work on metabolites and Yamina mentioned that they would use their discussion as a basis for crafting social media posts. Claudia, who has an interest in metabolites and their effects on the system, agreed. She also mentioned her team's job openings and where people could find more information.

Both receptors contain PSD-95/Discs-large/ZO-1 homology (PDZ) motifs in their C-terminal tails through which We hypothesized that this inhibition is a consequence of a plasma membrane complex of these receptors AKAP5 also inhibits β1AR-mediated cAMP production, which is not additive with GPR30-promoted inhibition These results argue that GPR30 and β1AR form a PDZ-independent complex in MCF7 cells through which GPR30 GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

thorough characterization of the network readily available for mathematical modeling to be useful, but we hypothesized that mathematical modeling could be useful when there is incomplete knowledge and that In the present study, we first develop a mechanistic mathematical model of a G-protein coupled receptor Overall, this work highlights the power of mechanism-based computational systems biology as a discovery GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

There was unusual shift in mortality and morbidity patterns during the second wave. Genetic variations were significant, with unique deletions identified, including a 12-nucleotide deletion Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

G protein-coupled receptors (GPCRs) are involved in endocrine and metabolic processes as well as many GPR50 expression was observed to be significantly increased in the adipose tissue of obese T2DM mice, while Authors Zhenyu Yao, Jun Meng, Jing Long, Long Li, Weicong Qiu, Cairong Li, Jian V Zhang, Pei-Gen Ren Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

Here, we cross-integrated large singe-cell RNA-sequencing datasets from CD8+ T cells covering 19 distinct These include EP2, EP4, A2AR, β1AR and β2AR, all of which promote T cell dysfunction. We also developed transgenic mice expressing a chemogenetic CD8-restricted Gαs-DREADD to activate CD8 Authors Victoria H Wu , Bryan S Yung , Farhoud Faraji , Robert Saddawi-Konefka , Zhiyong Wang , Alexander GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

During his doctoral work in the lab of Prof. Lefkowitz , where his research focused on biased agonism, with the development of approaches to quantify Sudarshan Rajagopal on the web LinkedIn Website Google Scholar LinkedIn Dr. Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

Steve’s work is focused on emerging technologies applied to Science, Technology, Engineering, and Mathematics During his time at UC San Diego Steve worked directly with the founding Chair of the Nanoengineering graduating from UCSD he founded Nanome Inc to build Virtual Reality solutions for Scientists and Engineers working Steve McCloskey on the web Website LinkedIn Twitter ResearchGate Medium Orchid Dr. Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

Tobi Langenhan "I studied medicine at the University of Würzburg, where I obtained my license to practice Then I moved to the University of Oxford on a 4-year Wellcome Trust Scholarship in Neuroscience, through which I gained an M.Sc. from Somerville College and a D.Phil. from Magdalen College Oxford, both in After returning to Germany I set up my own lab at the Institute of Physiology at Würzburg, where I later Tobi Langenhan on the web Langenhan Lab ORCID LinkedIn University of Leipzig Dr.

Her work is primarily focused on class B GPCRs and their interactions with RAMPs. She has gained experience from working in academia and at GSK as an industrial trainee. Join me and learn more about Debbie’s career and what she learned through her experiences as a scientist Debbie Hay on the web LinkedIn Wikipedia University of Otago University of Auckland Google Scholar Pubmed Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

Caron at Duke University (1994-1997), where he and his colleagues investigated the role of G protein-coupled Stephen Ferguson on the web Carlton University Canada Research Chairs Twitter ResearchGate LinkedIn Dr Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

His undergraduate thesis work on studying the biochemical mechanisms of flavonoids in cancer using nuclear His Ph.D. work has been focused on understanding the structure and activation of Class D fungal GPCRs He has developed novel tools and methodologies to study fungal GPCRs which allowed the determination This work has led to two first-authored manuscripts published in the journal Nature. Vaithish Velazhahan on the web Twitter GatesCambridge PubMed Dr.

At Harvard, I worked in the labs of Drs. Brian Kobilka at Stanford University at the end of 2017 for postdoctoral work. John Janetzko on the web Stanford University Stanford Medicine Google Scholar Personal Website ResearchGate He then moved to Dan's lab where he met Suzanne and her project. John also discussed the potential complications that arose when his then-girlfriend, now wife, was applying

Kathryn obtained her BS in Chemistry from Carnegie Mellon University and went on to receive a Ph.D. in Working under the supervision of Dr. John Traynor , Kathryn worked to develop and understand first-in-class allosteric modulators of opioid Research into their mechanism of action in purified systems formed the base of her thesis work. Kathryn E Livingston on the web LinkedIn ResearchGate Pubmed Google Scholar Dr.

Yamina Berchiche introduces the very first podcast dedicated to GPCRs researcher and their work. GPCR Ecosystem, with the goal is to bring together GPCR scientists, biotech, and pharma leaders as well as suppliers working on GPCRs by providing opportunities to connect, share, form trusting partnerships Yamina Berchiche on the web - Website - LinkedIn - PubMed - Twitter - Facebook - Dr. Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

She received her BSc in Human Biology from King’s College London in 1997, and while her Ph.D. commenced her Ph.D. in Molecular Endocrinology being awarded in 2002 with Distinction from the University of Western postdoctoral training at the University of California, San Francisco with Professor Mark von Zastrow where UK, Wellcome Trust, and the Medical Research Council. Aylin Hanyaloglu on the web LinkedIn Endocrine Metabolic GPCRs Researchgate Twitter Imperial College

Yamina Berchiche on the web Website LinkedIn Facebook Twitter ResearchGate PubMed Google Scholar Dr. work routines." Maria Waldhoer on the web LinkedIn T witter Pubmed Dr. GPCR About Dr. JoAnn Trejo "Dr. From 1987 to 1994, they were the Director of Biocomputing at The Salk Institute, where they managed institute-wide From 2002 to 2006, they were a Senior Application Scientist at Accelrys, where they were the technical

science and has been actively publishing papers about his ideas on how COVID symptoms could be treated while we wait for a vaccine, particularly about ACE2 and angiotensin. Paul Insel on the web Insel Laboratory Institute of Engineering in Medicine UC San Diego UCSD Profiles Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

His work has been applied to studies encompassing neurological and psychiatric disorders, cardiovascular long-term support from international and national competitive, charitable and commercial sources, as well Arthur Christopoulos on the web Monash University Wikipedia Google Scholar LinkedIn Dr. They also discussed the disruption within the pharmaceutical sector, the importance of workforce development , and the need for maintaining a healthy work-life balance.

Badr Sokrat on the web PubMed ResearchGate LinkedIn Dr. work-life balance. upon each other's work. when deciding on a postdoc position. She also mentioned the importance of careful communication, especially when working with a boss who has

Institute of Science, Bangalore, India, to investigate the mechanisms behind rare mitochondrial diseases, which I am now working at the Cleveland Clinic in Ohio, USA, studying the gut microbiome and its impact on Discovering these receptors would be a significant breakthrough in cardiovascular biology as they could Prasenjit Saha on the web Google Scholar Pubmed LinkedIn Dr. Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

20+ years of experience in in vitro and in vivo GPCR pharmacology and has published seminal papers where he used various approaches to describe the role of opioid receptors in pain and anagesia as well as Louis Gendron on the web Université de Sherbrooke Neurosciences Sherbrooke RQRD Pubmed Google Scholar

He then completed his Ph.D. at Leeds as well as the University’s Ackroyd, Brotherton, and Brown Scholar the Receptor Biology Section at the Medical Research Council (MRC) -Human Reproductive Sciences Unit within his scientific journey with the award of the highly-valued Odysseus Program Type I Program Grant to work Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

Here, we identify α2A-adrenergic receptor (ADRA2A) as a highly expressed GPCR in ISCs. Through PRESTO-Tango screening, we demonstrate that tyramine, primarily produced by Enterococcus via Authors Chaoliang Li , Panrui Zhang , Yadong Xie , Shishan Wang , Meng Guo , Xiaowei Wei , Kaiguang Zhang , Dan Cao , Rongbin Zhou , Sheng Wang , Xinyang Song , Shu Zhu , Wen Pan Tags Enterococcus , IBD , ISCs GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

Here we analyze the RGS domains of 15 RGS protein family members using a novel bioinformatic tool that We further focused on RGS14, RGS10, and RGS4. Using complimentary cellular and biochemical approaches, proteins were tested for effects on GPCR-G α of genetic intolerance in RGS proteins and prioritize which cancer-linked mutants to test. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

Previously, we identified potent positive crosstalk between insulin/IGF-1 receptors and G protein-coupled Here, we show that a combination of insulin and the GPCR agonist neurotensin induced rapid activation of Src family of tyrosine kinases (SFK) within PANC-1 cells, as shown by FAK phosphorylation at Tyr576 /577 and Tyr861, sensitive biomarkers of SFK activity within intact cells and Src416 autophosphorylation GPCR News and get weekly notifications about the GPCR field Share < Previous Next >