expand our knowledge of the cladoceran GPCR gene repertories which in part, mediate cell physiological mechanisms

isoform-specific GPR35 ligands that selectively modulate GPR35-transducer interactions and allow for mechanism-based

However, its biological function and underlying molecular mechanism in breast cancer have not been clearly

GPCRs share a common mechanism of action via the β-arrestin scaffolding signaling complexes, which not

Dimitrios Stamou, et al. for their work on the Molecular mechanism of GPCR spatial organization at the Function Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling Molecular mechanism

GPCRs are considered a well-established field, recent technological advances to dissect the molecular mechanisms

demonstrates the feasibility of producing milligram quantities of hTAS1R2-VFT to further characterize the mechanism

fluorescently labeled Hst1 (F-Hst1) targets and activates mitochondria, presenting an important molecular mechanism

Graphical Abstract A graphical abstract that illustrates the mechanisms by which Exendin-4 inhibits cardiac Mechanisms are assumed to occur in the cardiomyocytes and/or other resident cells such as fibroblast.

There are several reports that have addressed the differences in the mechanisms of transduction triggered This report highlights a mechanism of β-arrestin pathway activation dependent on G protein activation

Biased allosteric mechanisms Allosteric sites can differentially modulate G-protein and β-arrestin coupling the binding of allosteric agonists like PCO371 to Gs-proteins, further elucidating biased signaling mechanisms

We uncovered a novel neuroprotective mechanism involving interaction between neurotrophic factor-α1 (

degenerative diseases: Advances and future perspectives Non-canonical Golgi-compartmentalized Gβγ signaling: mechanisms

the CNS and it appears that chemokine/chemokine receptor signaling may be the most important leading mechanisms

We consider how receptor asymmetry may support the underlying mechanisms. © 2022 The Authors.

inflammation might be an integral part of the switch from pro- to anti-inflammatory action of sympathetic mechanisms

Topics include pharmacologic activity measurement, mechanisms of action, and GPCR discovery strategies

study, we established an experimental Sjögren's syndrome (ESS) mouse model to elucidate the molecular mechanisms

These alterations are essential for the complex mechanism of G protein activation, following GTP association

MN IME was also augmented by the physiological neuromodulator lysophosphatidic acid (LPA) through a mechanism

signature of CCR2 scavenging - no G proteins, no GRKs, no arrestins, and no clathrin Chemokine scavenging mechanism chemokine receptors scavenging population pathophysiology, a better understanding of the regulatory mechanisms

NEW MPGPCR Conference (November 15 -17, 2023) Structure, Mechanism, and Drug Interactions of GPCRs, Ion

Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Retreat (November 2 - 4, 2023) Structure, Mechanism

GPCRs Piconewton Forces Mediate GAIN Domain Dissociation of the Latrophilin-3 Adhesion GPCR Unveiling Mechanical

Their Ligandability Potential Molecular Dynamics (MD) Simulations Provide Insights into the Activation Mechanisms

GPCR Activation and Signaling Molecular Mechanisms of PTH/PTHrP class B GPCR Signaling and Pharmacological

The relaxin receptor RXFP1 signals through a mechanism of autoinhibition.

Conference (November 15 -17, 2023) ASCEPT Annual Scientific Meeting (November 20 -23, 2023) Structure, Mechanism