Sensor Approach for Drug Discovery for Human Adhesion GPCRs Stephanie Häfner Abstract "G Protein-coupled receptors (GPCRs) are common drug targets, yet no approved drugs exist for the Adhesion G Protein-coupled receptors The NRS fuses the extracellular region of any given aGPCR with a cleavage module from a Notch receptor in vivo by targeting the latrophilin-type aGPCR Cirl/ADGRL in Drosophila, revealing NTF release and receptor This tailored system aims to expedite the identification of drugs targeting the unique aGPCR receptor

Summary Arthur's Career Journey and Allosteric Receptors Yamina and Arthur discussed Arthur's career journey and his contributions to the field of pharmacology, with a focus on allosteric receptors and They also discussed their own research on chemokine receptors and the importance of understanding the and GRKs, with Arthur recounting his initial collaboration with Patrick Sexton on RAMPs and amylin receptors They also delved into the different signaling of Class B receptors and the potential for modulation at

Holo-Adhesion GPCR Demet Araç Heterogeneity of Tethered Agonist Signaling in Adhesion G Protein-Coupled Receptors It has been suggested that the TA can regulate receptor signaling without coming out of the GAIN domain activation, suggesting that non-release or partial release of the TA is unlikely to activate the receptor As an undergraduate, he studied opioid receptor trafficking and G protein conformational dynamics in We utilize several genetically modified mouse models to investigate requirements for receptor activator

< GPCR News < GPCRs in Oncology and Immunology Unveiling G-protein coupled receptors as potential targets Currently, very few G-protein coupled receptors (GPCRs) have been investigated for active targeting with

By combining experimental data with theory on leukocyte chemotaxis guided by the G protein-coupled receptor (GPCR) CCR7, we demonstrate that in addition to its role as the sensory receptor that steers migration Upon exposure to the CCR7 ligand CCL19, dendritic cells (DCs) effectively internalize the receptor and

heterogeneity in fibroblast-associated diseases Published date August 1, 2023 Abstract "G protein-coupled receptors (GPCRs) are the largest and most diverse class of signaling receptors. GPCRs regulate many functions in the human body and have earned the title of "most targeted receptors

Graciela Pineyro’s love for GPCR pharmacology started in Uruguay where she first worked on the serotonin receptors Graciela has done extensive work on the molecular pharmacology of opioid receptors, exploring their signaling

degree in biochemistry from Leipzig University (Germany) being already fascinated by G protein-coupled receptors They also discussed the challenges of studying metabolites and their receptors, the relationship between Challenges in Studying Metabolites and Receptors Claudia and Yamina discussed the challenges of studying metabolites and their receptors, particularly in relation to fermented foods. They also explored the potential for better tools to understand and discover new metabolites or receptors

Mark von Zastrow where she identified novel core cellular machinery critical for G protein-coupled receptor cell biological mechanisms regulating GPCR activity, including spatial control of GPCR signaling and receptor postdoctoral research in Oxford, investigating the signalling and trafficking of the G protein-coupled receptor (GPCR), calcium-sensing receptor, and its role in calcium homeostasis.

activation of the SK1-S1P1 signaling axis Published date August 15, 2023 Abstract "The G protein-coupled receptor the S1P signaling axis, including an enzyme that generates S1P [sphingosine kinase 1 (SK1)], an S1P receptor [S1P receptor 1 (S1P1)], and S1P itself.

) in largemouth bass (Micropterus salmoides) Published date October 24, 2024 Abstract "CC chemokine receptors (CCRs), the numbers of the G protein-coupled receptor (GPCR) superfamily, had crucial roles in treating Our results provided basis for elucidating the functions of chemokine-receptor complex in largemouth

assistant at the Victor Chang Cardiac Research Institute where he investigated the orphan G protein-coupled receptor Brendan is now a final year PhD candidate in the Orphan Receptor Laboratory headed by Associate Professor

Pluznick discovered that olfactory receptors in mice are also expressed in their kidneys and blood vessels GPCRs in regulating renal and cardiovascular function, and identifying renal/cardiovascular olfactory receptor

Shenoy’s postdoctoral research discovered that ubiquitination of mammalian G protein-coupled receptors for lysosomal degradation, whereas ubiquitination of the adaptor protein, β-arrestin, is a tag for receptor

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the

Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors Sachdev pursued Ph.D. in the same lab where she investigated the molecular pharmacology of cannabinoid receptors

John Traynor , Kathryn worked to develop and understand first-in-class allosteric modulators of opioid receptors There she researched the beta-2 adrenergic receptor and developed assays to investigate real-time activity

During his graduate studies, Emile is interested in characterizing novel G protein-coupled receptors Title: Synapse-Associated Protein 102 and Post-Synaptic Density 95 Differentially Shape Dopamine D1 Receptor Signaling About Bassam Albraidy "My thesis focus on studying the interaction of dopamine D1 receptors

infectious inflammation Published date January 1, 2023 Abstract We recently found that the G protein coupled receptor Herein, we investigated the endogenous role of this pro-resolving receptor in modulating macrophage biology in the expression of phenotypic and activation markers, including the Interleukin (IL)-10 and IL-23 receptors

Lysophosphatidic acid (LPA) is a lipid that activates G protein-coupled receptors (GPCRs), enhancing In these cells, the mitogenic activity of LPA is mediated by LPA Receptor 1 (LPAR1), a GPCR. Specifically, CCNs secreted into the extracellular space can facilitate the activation of additional receptors

Finally, we identified that G protein-coupled receptor (GPCR)-phospholipase C (PLC)-inositol trisphosphate receptor (IP3R)-store-operated Ca2+ (SOC) signaling was crucial for enhancive cytosolic Ca2+ and PEDV G protein-coupled receptor (GPCR)-phospholipase C (PLC)-inositol trisphosphate receptor (IP3R)-SOC signaling

and worked closely with Dr Birgitte Holst studying structural and mechanistic properties of ghrelin receptor associated with obesity and other metabolic diseases, including GPR10, Melanocortin 4, Serotonin 2C and TRH receptors cell-based in vitro technologies to study mechanistic properties of GPCRs and understanding the dynamics of receptor Jacek shared his fascination with the growth hormone secretion receptor and the melanocortin 4 receptor Yamina, in turn, talked about her work on melanocortin receptors and an upcoming collaboration with a

Hannes Schihada Following studies in Pharmacy in Regensburg, Germany, I joined the receptor pharmacology I spent 2 1/2 years in his lab and developed novel conformational sensors for these intriguing receptors

episode Fiona Marshall got fascinated with GPCRs after attending a lecture on how the beta-adrenergic receptor biology, Fiona published the first description of the cloning and structural requirements of the GABAB receptor

pharmacology, and pharmacoepidemiology with innovative computational methods to gain novel insights into receptor identify human signaling systems and thereby discovered endogenous peptides activating several orphan receptors

focuses on the mechanisms underlying biased signaling at GPCRs, specifically, the role of differential receptor He primarily studies the chemokine receptor CXCR3 as it has three naturally occurring ligands and thus

< GPCR News < GPCRs in Oncology and Immunology Lactate receptor GPR81 drives breast cancer growth and properties and Notch ligand DLL4 Published date November 22, 2023 Abstract " Background: The lactate receptor

Immunology Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Moreover, the GBP2-induced response was silenced by pre-treatment with dsRNA targeting the GBP receptor