Here, we demonstrated that GASP1 was highly expressed in breast cancers, and patients harboring altered

Endocrinology, and Taste GPCR-mediated regulation of beige adipocyte formation: Implications for obesity and metabolic

These alterations are essential for the complex mechanism of G protein activation, following GTP association

GPCRs in Neurodegenerative Disorders: Integrating Structural Biology and Drug Discovery Approaches Altered

Alterations in the expression and/or activity of brain G-protein-coupled receptors (GPCRs) such as dopamine

long-term Reprogramming of hypothalamic-pituitary axis in mice GPCRs in Oncology and Immunology A disturbed metabolite-GPCR

of G proteins from canonical GPCR-dependent pathways by growth factor signaling might contribute to altered

The structures reveal that transmembrane helices TM5 and TM6 alternate lengths as a macro-switch to determine

expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration after However, the potential role of GPR3 in axonal regeneration after neuronal injury has not been elucidated Herein, we investigated retinal GPR3 expression and its possible involvement in axonal regeneration after regeneration using GPR3 knockout mice revealed that GPR3 in RGCs participates in axonal regeneration after suggest that GPR3 expression in RGCs helps maintain neuronal survival and accelerates axonal regeneration after

Furthermore, a plethora of TRPM3 variants that result from alternative splicing have been identified

and Bitter Receptor Responses to Sequential Injections of Pure and Mixed Sweeteners GPCRs involved in metabolic

were used in order to clarify additional possible molecular signaling pathways which contribute to alterations

Hence, the H3R conformational biosensor in membranes might be a ready-to-use, high-throughput alternative

an Entrepreneur Of The Year® 2024 Pacific Southwest Award Winner Monlunabant by Inversago Pharma for Metabolic

2AR is sufficient to intrinsically bias the β 2AR away from β -arrestin interaction and demonstrates altered

Alternative splicing events account for hundreds, if not thousands, of potentially divergent isoforms present an interactive browser-based application, Splice-O-Mat, for understanding tissue distribution of alternatively

standards for quantitative Western blot analysis of cannabinoid CB1 receptor density in cell membranes: an alternative

We then demonstrate that sub-cellular localization and alternative signaling pathways may be responsible

GPCRs in Cardiology, Endocrinology, and Taste Metabolic depletion of sphingolipids inhibits agonist-induced

Such alterations can also extend to β-arrestin expression levels, potentially affecting the composition In certain cancer types, only one β-arrestin isoform's expression may be altered, while the other remains

the management of acute pain severe enough to require an intravenous opioid analgesic and for whom alternative

immune and gastrointestinal cells, we show that these isoforms emerge from distinct promoter usage and alternative

independent endosomal G protein activation by the vasopressin type 2 receptor GPCR Binders, Drugs, and more Altered

In nematodes, exposure to PS-NPs (1-100 μg/L) significantly altered transcriptional expressions of some

Metabolic depletion of sphingolipids inhibits agonist-induced endocytosis of the serotonin1A receptor

OR10J5 has been proposed to be a metabolic regulator of cardiac function (Jovancevic N. et.

Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5 Altered

This variation is due to factors such as alternative splicing, gene duplications, and variability in