the first described synthetic agonists and antagonists of the FSHR and has been an early champion of signaling His recently published book on signaling bias, Biased Signaling in Physiology, Pharmacology, and Therapeutics

the first described synthetic agonists and antagonists of the FSHR and has been an early champion of signaling His recently published book on signaling bias, Biased Signaling in Physiology, Pharmacology, and Therapeutics

Many MT2 variants are biased and their defects are signaling pathway-specific opening new perspectives

In addition to contributing to energetic and biosynthetic demands, metabolites can also function as signaling intracellularly to influence metabolism, oxidative response, epigenetic modification, and gene expression and to signal in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were enrichment analysis revealed the promising therapeutic effects of these targets on GPCRs-related cancer pathways in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

tumor microenvironment Published date November 20, 2023 Abstract " Background: Regulator of G protein signaling 5 (RGS5), as a negative regulator of G protein-coupled receptor (GPCR) signaling, is highly expressed Yu Song , Wen-Di Zhang , Rui-Juan Guo , Han Li , Mei Han Tags Breast cancer , Regulator of G protein signaling in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

5, 2024 The G protein-coupled receptor ADGRG6 maintains mouse growth plate homeostasis through IHH Signaling Read More May 14, 2024 Illuminating GPCR Research: FRET and BRET-Based Sensors Shed Light on Cellular Signaling Pharmacology Read More September 6, 2023 opnMe GPCR Route 66+ project Read More October 1, 2022 GPCRs: Signal by commensal bacteria potentiate GLP-1 secretion as GPCR ligands Read More Receptor Activation and Signaling

GNAS samples identified by nontargeted proteomics and involved in G protein-coupled receptor (GPCR) pathways The results suggested that GNAS mutations impact endocrinological features in acromegaly through GPCR pathway in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking, and signaling His research career has focused on the investigation of the regulation of G protein-coupled receptors signaling of Health Research (CIHR) for his research investigating the role of metabotropic glutamate receptor signaling

atypical receptors and non-GPCR binding partners that cumulatively influence discrete pharmacological signaling gradients and illustrate how differences between ligand recognition and receptor activation influence the signaling in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

engineers and computer scientists focusing on the basic mechanisms of G protein-coupled receptor (GPCR) signalling To study GPCR signalling, they develop and use innovative optical methods based on FRET and single-molecule microscopy, which allow them to directly observe signalling events in living cells and tissues with

Back to Full Agenda Session I Tethered agonist - dependent/independent activation mechanism in AGPCRs Signaling Region with Transmembrane Domain in a Holo-Adhesion GPCR Demet Araç Heterogeneity of Tethered Agonist Signaling It has been suggested that the TA can regulate receptor signaling without coming out of the GAIN domain The TA peptide remains at its original position and is not involved in signaling. Demet Araç on the web Araç Laboratory at UChicago X (Twitter) Heterogeneity of Tethered Agonist Signaling

reveal that the therapeutic effects of CB2 are mediated through activation of the AKT, ERK1/2, and CREB pathways in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking, and signaling His research career has focused on the investigation of the regulation of G protein-coupled receptors signaling of Health Research (CIHR) for his research investigating the role of metabotropic glutamate receptor signaling

In the Rajagopal Lab, Julia studies the mechanisms of 'biased signaling' at GPCRs, with a specific focus translocate to endosomes, and that the subcellular localization of the GRKs affects a GPCR's biased signaling

she obtained her Ph.D. at the University of Western Ontario, working on the regulation of G proteins signaling Her current research focuses on class B GPCRs and understanding how GPCR signaling and function is mediated

October 29, 2024 Abstract "The intestinal lumen is rich in gut microbial metabolites that serve as signaling G-protein-coupled receptors (GPCRs) sense metabolites and can act as key mediators that translate gut luminal signals in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

various alternatively spliced isoforms thus potentially resulting in differential modulation of cell signaling pathways. lab highlighted the importance of splicing events in biasing latrophilins’ regulation of cyclic AMP pathways

ubiquitination of the adaptor protein, β-arrestin, is a tag for receptor internalization and formation of signaling Current efforts aim to understand the regulation of GPCR and beta-arrestin signaling in the heart and

understanding the role of the membrane microenvironment in the subcellular organization, trafficking, and signaling the interaction of membrane cholesterol with the serotonin-1A receptor and its effects on receptor signaling

Annabelle’s Ph.D. work focuses on microbial-derived metabolites that signal through GPCRs expressed in In particular, she is looking at L- and D-lactate-activated HCAR1 signaling.

cells promotes the secretion of chemokines and polarizing factors through activating PI3K/AKT/NF-κB pathway in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

Beaulieu has pioneered work establishing a role for Beta-arrestin signaling in the brain in vivo and has demonstrated that mood stabilizer drugs (e.g. lithium) used for bipolar disorder therapy target signaling is presently investigating how cell surface express proteins can act as allosteric modulators of D2R signaling

exposure to CPPDQ potentially resulted in neurotoxicity by inhibiting TGF-β, JNK MAPK, and ERK MAPK signals The inhibition in JNK MAPK and ERK MAPKs signals in CPPDQ exposed nematodes was further related to alteration in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

the past two decades, his lab has published numerous groundbreaking findings shedding light on the signaling Most recently, his lab has made a number of seminal contributions to understanding the signaling, regulation has a special interest in studying disease-associated mutations to human GPCRs that perturb receptor signaling

receptor (GPCR)-phospholipase C (PLC)-inositol trisphosphate receptor (IP3R)-store-operated Ca2+ (SOC) signaling G protein-coupled receptor (GPCR)-phospholipase C (PLC)-inositol trisphosphate receptor (IP3R)-SOC signaling Tags calcium signaling , infection , interleukin-8 , porcine epidemic diarrhea virus , therapy . in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

The Department’s strengths lie in GPCR signal transduction and neuroscience, and she has expanded it research focuses on the structure and function of GTP binding proteins and the molecular mechanisms of signal Her laboratory has been involved in studying G protein coupled signal transduction for many years and Current areas of interest include Protease Activated Receptor signaling in the cardiovascular system

I then undertook my first project where I demonstrated that MRAP2 regulates the signaling of multiple Concurrently, I described the mechanisms by which MRAP2 regulates GHSR1a signaling; this project brought Using this novel technique, I showed that MRAP2 biased GHSR1a signaling and shut down its constitutive activity; this work resulted in a first author publication in Science Signaling. to create a scientific session at the American Physiology Summit (APS) 2024 dedicated to GPCR biased signaling