Search Results
197 items found for "POTS"
- Single-molecule counting applied to the study of GPCR oligomerization
technique of quantitative single-molecule localization microscopy-with a particular emphasis on the potential
- Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of...
pharmacology method was used to constructe the "herb-component-target" network, and elucidated KXS potential
- Activation of GPR183 by 7 α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through...
of dorsal-horn spinal cord (DH-SC) tissues harvested at the time of peak hypersensitivity implicate potential
- Adenosine receptor signalling in Alzheimer's disease
review, we provide an accessible summary of the literature on Alzheimer's disease and the therapeutic potential
- Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental...
development and preeclampsia, and outlined the relevant pathological mechanisms, thereby providing potential
- Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin...
to prevent skin dysbiosis and bacterial infection "Healthy skin maintains a diverse microbiome and a potent
- Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable to...
To this end, we comprehensively analyzed the potential role of ADGRA1 in the neurobehaviors of mice by function by regulating the PI3K/AKT/GSK-3β and MEK/ERK pathways in amygdalae of male mice, implicating a potential
- Structural view of G protein-coupled receptor signaling in the retinal rod outer segment
Although hypothetical, the reconstruction of the rod phototransduction system highlights the potential
- ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the...
GIP has been linked to the pathogenesis of diabetes mellitus, and our analyses suggest a potential link
- Allosteric modulation of GPCRs: From structural insights to in silico drug discovery
orthosteric site), allosteric modulators offer new avenues for the regulation of GPCR function with potential
- Developing the Cannabinoid Receptor 2 (CB2) pharmacopeia: past, present, and future
CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealized, therapeutic potential
- Molecular insights into psychedelic drug action
2022 "A confluence of factors has renewed interest in the scientific understanding and translational potential
- Molecular targets of psychedelic-induced plasticity
placed on knowledge gaps, challenges, and limitations to evaluate the underpinnings of psychedelics' potential
- Adenosine receptor signalling in Alzheimer's disease
review, we provide an accessible summary of the literature on Alzheimer's disease and the therapeutic potential
- Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin recept
Systematic modification of 1 was performed to produce compounds with improved potency and ADME properties Orally bioavailable compound 47 with favorable agonist potency (Ca2+EC50 = 24 nM, cAMPi EC50 = 6.5 nM In summary, a potent and selective APJ agonist suitable for in vivo studies of APJ in peripheral tissues
- Exploring pharmacological inhibition of G q/11 as an analgesic strategy
One potential solution is to develop analgesics that act at targets other than opioid receptors. The aim of this study was to test this hypothesis pharmacologically by using potent and selective Gq/
- A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology in...
In addition, we have validated the H3R biosensor in membrane preparations and found that observed potency
- GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal...
However, the potential role of GPR3 in axonal regeneration after neuronal injury has not been elucidated
- Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response
These structures reveal an agonist binding site for the oxysterol and a potential ligand entrance site
- Fusion protein strategies for cryo-EM study of G protein-coupled receptors
Although a similar strategy has the potential to broadly facilitate cryo-EM structure determination of
- Dopamine D 1 receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, behavior...
signaling: Insight from pharmacology, biology, behavior, and neurophysiology "The awareness of the potential
- In vitro assays for the functional characterization of (psychedelic) substances at the serotonin...
Besides their appearance on the (illicit) drug market, e.g. as new psychoactive substances, their potential
- Signaling pathways activated by sea bass gonadotropin-inhibitory hormone peptides in COS-7 cells...
further elucidated the intracellular signaling pathways mediating in sea bass GnIH actions and the potential
- A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation
homodimerization has a setmelanotide-like effect on Gq/11 signaling, with chimeric receptors presenting increased potency These findings indicate the potential of inhibiting MC4R homodimerization as a therapeutic target to
- Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but...
familial hypocalciuric hypercalcemia type-1 (FHH-1), supported maximal signaling with reduced Ca2+o potency Thus two WT VFT domains were required for normal Ca2+o potency and there was a pronounced gene-dosage
- GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation
of GPR84 in innate immune cells and intestinal inflammation, and suggest that GPR84 may serve as a potential
- Molecular insights into regulation of constitutive activity by RNA editing 5HT2C serotonin receptor
These 5HT2C isoforms display differences in constitutive activity, agonist/inverse agonist potencies,
- High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and...
results may supply new insights into GPER-mediated estrogen carcinogenesis in TNBC, thus providing a potential