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338 items found for "Regulator of G protein signaling 6"

  • The power of many: Multilevel targeting of representative chemokine and metabolite GPCRs in personalized cancer therapy

    chemokine and metabolite GPCRs in personalized cancer therapy Published date September 12, 2024 Abstract "G protein-coupled receptors (GPCRs) are vital cell surface receptors that govern a myriad of physiological Despite their crucial role in regulating antitumor immunity and tumorigenesis, therapeutic applications in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Ep 111 with Chloe Hicks

    January 2021 and has contributed to multiple projects exploring the underlying mechanisms of biased signaling These previous endeavors involved exploring the effect of subcellular location on the signaling profile biased ligands, elucidating the role of site-specific receptor phosphorylation in the differential signaling She is currently working on her senior thesis which involves identifying the non-canonical signaling protein and has been shown to maintain its activation in the absence of β-arrestin.

  • GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis

    However, the regulation mechanisms that determine exosome contents during exosome biogenesis remain poorly the GPR143-ESCRT pathway promotes secretion of exosomes that carry unique cargo, including integrins signaling proteins. These findings provide a mechanism for regulating the exosomal proteome and demonstrate its ability to in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro

    protein-coupled receptors (GPCRs) play important roles in tumorigenesis and the development of hepatocellular To detect the role and the regulation mechanism of GPR50 in HCC, GPR50 expression was analyzed in HCC GSE45436)) and detected in HCC cell line CBRH-7919, and the results showed that GPR50 was significantly up-regulated The regulation mechanism of GPR50 in HCC was detected by isobaric tags for relative and absolute quantification in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Investigating isoform switching in RHBDF2 and its role in neoplastic growth in breast cancer

    targets for cancer therapy focused on the assumption that one gene is responsible for producing one protein mechanism is an irreversible process that aids in regulating cellular growth during tumorigenesis. of EGFR ligands via the ERAD pathway or positively regulate EGFR ligands via the EGFR signalling pathway MAPK signalling pathways, GPCR signalling pathways, and toll-like receptor pathways. switches back to the canonical isoform, and the proteasomal degradation pathway and cytoplasmic ribosomal protein

  • GprC of the nematode-trapping fungus Arthrobotrys flagrans activates mitochondria and reprograms fungal cells for nematode hunting

    the nematode-trapping fungus, Arthrobotrys flagrans, that both are achieved through a dual-function G-protein-coupled revealed that ascarosides activate the fungal GPCR, GprC, at the plasma membrane and together with the G-protein An SRBC64/66-GprC chimaeric protein was functional in A. flagrans, and C. elegans SRBC64/66 and DAF38 in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Molecular docking and dynamics simulation studies uncover the host-pathogen protein-protein interactions in Penaeus vannamei and Vibrio parahaemolyticus

    Oncology and Immunology Molecular docking and dynamics simulation studies uncover the host-pathogen protein-protein The P. vannamei-V. parahaemolyticus protein-protein interaction of Complex 1 (Ferritin-HrpE/YscL family type III secretion apparatus protein), Complex 2 (Protein kinase domain-containing protein-Chemotaxis CheY protein), and Complex 3 (GPCR-Chemotaxis CheY protein) was found to interact with -4319.76, -5271.39 in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Emerging GPCR targets for AUD: Insights from preclinical studies

    Emerging GPCR targets for AUD: Insights from preclinical studies Published date July 5, 2024 Abstract "G protein-coupled receptors (GPCRs) are the largest group of membrane receptors in the central nervous system and one of the key proteins for signal transduction between cells. in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation

    After 2-24 h, brains were collected for the analysis of gene expression by RT-PCR or protein expression GPR110 ligand decreased the mRNA and/or protein expression of these cytokines and Iba-1 in the WT but PDE4B expression at both mRNA and protein level in the brain increased after ethanol and LPS treatment ethanol by counteracting on the cAMP system, the common target for synaptamide and ethanol, and by regulating in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Session VII | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    Drosophila Beatriz Blanco Redondo Abstract "The Drosophila genome contains five loci encoding adhesion G-protein Remo homolog ADGRA2/Gpr124 cooperates with other GPCRs of the Frizzled family, and the transmembrane proteins RECK and Lrp5/6. Collectively these proteins form a cell surface complex that acts as a recognition platform for Wnt ligands University, Leipzig, Germany 5 Institute for Drug Discovery, Faculty of Medicine, Leipzig University 6

  • Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic diseases

    polyangiitis , European Medicines Agency , FDA , FcεRIα , FeNO , Fractional exhaled nitric oxide , G-protein-coupled protein-coupled receptor 11 , Mas-related family of G protein-coupled receptor X1 , Mas-related family of G-protein-coupled receptor 3 , Mas-related family of G-protein-coupled receptors , Mitogen-activated from baseline , Prurigo nodularis , SP , STAT , Sialic-acid-binding immunoglobulin-like lectin 8 , Signal in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody

    PRL3 in pediatric tumors in relation to survival outcomes, expression of angiogenesis markers, and G-protein-coupled receptor (GPCR)-mitogen-activated protein kinase (MAPK) signaling targets. Microarray profiling of PRL3-positive tumors showed elevation of angiogenin, TIMP1 and TIMP2, and GPCR-MAPK signaling proteins that commonly interacted with PRL3. in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • The β2-adrenergic receptor associates with CXCR4 multimers in human cancer cells

    cancer cells Published date April 2, 2024 Abstract "While the existence and functional role of class C G-protein-coupled PIE-FCCS can resolve membrane protein density, diffusion, and multimerization state in live cells at Lee , Yoonjung Jo , Yong Bhum Song , Chulo Park , Piotr Zalicki , Jae-Yeon Jeong , Won-Ki Huh , Niña G Caculitan , Adam W Smith Tags G-protein-coupled receptors , fluorescence spectroscopy , membrane protein in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression

    date July 22, 2024 Abstract "Fibrosis is characterized by excessive deposition of extracellular matrix proteins Although G protein-coupled receptors (GPCRs) are among the targets of current antifibrotic drugs, no This suggested that Gpr176 regulates fibroblast activation. in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • GPR37 expression as a prognostic marker in gliomas: a bioinformatics-based analysis

    GPR37 is an orphan G protein-coupled receptor (GPCR) that is implicated in different physiological pathways In addition, GSEA showed that GPR37 was positively correlated to the positive regulation of macrophage derived foam cell differentiation, negative regulation of T cell receptor signaling pathway, neuroactive ligand receptor interaction, calcium signaling pathway, and negatively associated with immunoglobulin in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Plenary Lecture | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    Available for AGPCR24 Attendees About Jin-Peng Sun "Since starting my laboratory in 2011, I has focused on G protein coupled receptors, in particular, the ligand identification, physiological functions and molecular mechanism of biased signaling of GPCRs. For arrestin mediated biased signaling, we have proposed the “flute model” and “poly proline region docking receptor GPR64 forms complex with β-arrestin-1 and CFTR at apical membrane of efferent ductulus to regulate

  • Ep 127 with Dr. Evi Kostenis

    Research interests: Signaling mechanisms involving GPCRs and heterotrimeric G proteins" Dr.

  • GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23/IL-17 axis signal pathway

    GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23/IL-17 axis signal This autoimmune loop in psoriasis pathogenesis is influenced by G protein-coupled receptor (GPCR) signalling in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • C5aR2 receptor: The genomic twin of the flamboyant C5aR1

    The C5aR1 is a classical G-protein-coupled receptor (GPCR), whereas C5aR2 is a nonclassical GPCR that tailors immune cell activity potentially through β-arrestins rather than G-proteins. Das, Pulkit K Gupta, Soumendra Rana Tags C5a; C5aR2/C5L2 receptor; lipid bilayer; molecular dynamics; protein-protein in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • A positive Allosteric Modulator of M1 Acetylcholine Receptors Improves Cognitive Deficits in Male and Female Alzheimer’s Mice

    Molecular Medicine and Neuroscience at the University of Ottawa as a Postdoctoral Fellow to explore novel G protein-coupled receptor (GPCR) candidates that can be targeted pharmacologically to slow neurodegeneration He has been also studying what aspects of GPCR signaling are regulated in a sex-selective manner and

  • Ep 45 with Dr Ralf Jockers

    Strosberg AD in France, where he worked on the regulation of ß-adrenergic receptors. He is the Research director at INSERM with a specific interest in G protein-coupled receptors by developing Many MT2 variants are biased and their defects are signaling pathway-specific opening new perspectives

  • Ep 79 with Dr. Graeme Milligan

    His main research group centers on the function, structure, and regulation of G protein-coupled receptors (GPCRs) and their interacting proteins. knowledge generated into the selection of targets, screening, and identification of small molecule regulators of these proteins, and progressing such ligands in drug development programs.

  • Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells

    , 2023 Abstract "T cell antigen receptor stimulation induces tyrosine phosphorylation of downstream signaling Previously, we reported that the G-protein-coupled human muscarinic receptor could bypass tyrosine kinases Here, we demonstrate that stimulating G-protein-coupled muscarinic receptors (M1 and synthetic hM3Dq) Tags GPCR; T cells; muscarinic receptor; signaling. in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Ep 146 with Dr Michael Feigin

    Craig Malbon at SUNY Stony Brook studying the role of G-protein coupled receptors (GPCRs) and their regulators in the Wnt signaling pathway. They also discussed his research on cell polarity and its role in cancer progression, his work on G-protein vitro to in vivo work, and Mike explained that he wanted to use better models to understand cancer signaling He also discussed his work on G-protein coupled receptors (GPCRs) in breast cancer, identifying GPR161

  • Ep 110 with Dr. G. Aditya Kumar

    G. Aditya Kumar About Dr. G. Aditya Kumar Dr. understanding the role of the membrane microenvironment in the subcellular organization, trafficking, and signaling the interaction of membrane cholesterol with the serotonin-1A receptor and its effects on receptor signaling G.

  • Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory diseases and cancers

    diseases and cancers Published date March 15, 2023 Abstract " C-X-C motif chemokine receptor 2 (CXCR2) is G protein-coupled receptor (GPCR) and plays important roles in various inflammatory diseases and cancers Hence, we provide an overview containing the discovery history, protein structure, signaling pathways in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

  • Ep 47 with Dr Simone Promel Dr Ines Liebscher

    on the different modes of action of Adhesion GPCRs and found that they do not only mediate classical G protein signals into cells but can also communicate solely via their N termini. Today, she and her team are working on the questions of how Adhesion GPCRs integrate the different signals Starting with proving and characterizing G-protein coupling, Ines spends several years studying the activation

  • Ep 66 with Dr. Antony A. Boucard Jr

    Alfred Gilman , Nobel Laureate for his discovery of G proteins, Dr. pharmacology of latrophilins brings about a great deal of challenges given that they are highly polymorphic proteins various alternatively spliced isoforms thus potentially resulting in differential modulation of cell signaling His lab highlighted the importance of splicing events in biasing latrophilins’ regulation of cyclic AMP

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