Robert Lütjens , Head of Discovery Biology, will provide a business update and review its pipeline during

August 2022 "The atypical chemokine receptor 1 (ACKR1) was discovered on erythrocytes as the Duffy blood group antigen ( Cutbush et al., 1950 ), also called Duffy-antigen/receptor for chemokines, or DARC ( Accordingly, within the erythroid lineage ACKR1 expression occurs first and is the highest in erythroblasts ( Duchene Pruenster et al., 2009 ; Thiriot et al., 2017 ), including those lining bone marrow (BM) sinusoids ( Duchene

Founded as a spinout from the University of Dundee on 20 July 2012, Exscientia pioneered the design

on the use of crinecerfont in adolescent patients with classic congenital adrenal hyperplasia (CAH) due

This increase is at least partially due to a significant decrease in agonist-promoted phosphorylation

Unlike LGR2 in other insect species, HLGR2 was found to play a crucial role in the control of H. cunea during

Despite this, the prognosis remains poor, with an impacted quality of life during treatment coupled with

Train-dependent presynaptic Ca2+ accumulation forces frequency-dependent recovery of neurotransmission during

During development, PGE2 signaling regulates embryogenesis, hepatocyte differentiation, hematopoiesis

that spatially restricted postsynaptic cAMP signals organize assembly of postsynaptic specializations during

Molecular docking displayed low binding energies during the intermolecular interactions of kurarinone

receptors enriched in SKM has only a limited impact on whole-body glucose homeostasis, most likely due

significantly different in the two receptor subtypes, as assessed by metadynamics simulations, and during

GPA-10 functioned to transduce signals of multiple GPCRs to different downstream signaling pathways during

study with the selective M4 agonist HTL-0016878 in schizophrenia in 2022 and Phase 1 studies for a dual