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279 items found for "Tatiana Da Ros"
- VAMP2: a crucial player in the delivery of MOR to the synapse
regulated that involves multiple molecular players, including SNARE proteins; here, SNARE proteins play a role
- 📰 GPCR Weekly News, April 3 to 9, 2023
GPCRs in Cardiology, Endocrinology, and Taste Novel roles for G protein-coupled receptor kinases in cardiac Methods & Updates in GPCR Research The Road to Quantitative Lipid Biochemistry in Living Cells.
- Feeder or trigger – CCR2 as a scavenger and regulator of cell migration
In this study, the molecular signature of CCR2 scavenging role is investigated. In this study, the role of these 3 molecular players (G proteins, GRKs, and β-arrestin) is investigated In this study, it is revealed that CCR2 scavenging role was largely independent of the classical GPCR But why do canonical chemokine receptors have this dual role in physiology? How balanced is this dual role?
- 📰 GPCR Weekly News, March 27 to April 4, 2023
ICL1-9-Mediated β2-Adrenergic Receptor-Dependent Cardiomyocyte Contractility Occurs in a Gi Protein/ROCK Insights into GPCR Function Predicted Three-Dimensional Structure of the GCR1 Putative GPCR in Arabidopsis thaliana
- 📰 GPCR Weekly News, March 13 to 19, 2023
GPCRs in Oncology and Immunology Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists Therapeutics unveiled its 2023 women-men professional equality index Octant introduces Hypatia, their New Robotic
- 📰 GPCR Weekly News, March 6 to 12, 2023
Industry News Professor Dame Carol Robinson Received 2023 ASMS John.B.Fenn Award Exscientia Announces
- 📰 GPCR Weekly News, February 20 to 26, 2023
A robust approach for MicroED sample preparation of lipidic cubic phase embedded membrane protein crystals A growing understanding of the role of muscarinic receptors in the molecular pathology and treatment
- Regulators of G-protein signaling: essential players in GPCR signaling
G-protein heterotrimeric complex (α, β, and γ); it is at this point when the RGS proteins play a key role Role of RGS proteins in regulating GPCR signaling: Recent studies have revealed that the interaction As negative regulators of GPCR signaling, RGS proteins play a critical role in regulating the duration In cardiovascular disease, RGS proteins play a critical role in regulating blood pressure and vascular Avrampou, K., et al., RGS4 Maintains Chronic Pain Symptoms in Rodent Models.
- 📰 GPCR Weekly News, February 13 to 19, 2023
tyramine signalling in Aedes aegypti: Molecular characterization and insight into potential physiological roles
- Glyco-sulfo hotspots in the chemokine receptor system
CCR5 O-glycosylation, which is under investigation in this study, also plays a major role in promoting CCR5 sulfation has been also reported to play a key role in CCL3 and CCL5 binding (Bannert N et al. 2001 was able to partially rescue the signaling upon reduction of sulfation, suggesting the fine-tuning role increase in the general negative charge of the cell surface glycosaminoglycans which have an established role
- 📰 GPCR Weekly News, January 30 to February 5, 2023
The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards Insights into GPCR Function Structural view of G protein-coupled receptor signaling in the retinal rod
- 📰 GPCR Weekly News, January 23 to 29, 2023
The role of intracellular calcium and Rho kinase pathways in G protein-coupled receptor-mediated contractions
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
Roughly half of the receptors in the superfamily are sensory GPCRs, involved in olfaction, taste, vision financing to develop GPCR-targeting nanobodies. · Septerna: closed a $100 Million USD Series A round against difficult-to-drug GPCRs. · Domain Therapeutics: completed a $42 Million USD Series A round endothelial transmigration model, OB-004 demonstrated an unprecedented level of monocyte blockade, robustly driven in silico-based molecular interaction prediction, will inevitably lead to a more and more central role
- 📰 GPCR Weekly News, January 16 to 22, 2023
Structural and Molecular Insights into GPCR Function The role of G protein conformation in receptor-G
- 📰 GPCR Weekly News - January 9 to 15, 2023
Sciences Senior Scientist, Drug Metabolism and Pharmacokinetics PhD Opportunity - Investigation Of The Role
- Odorant receptors – a bit of smell for drug discovery
including the testis, lung, intestine, skin, heart, and blood, where they can play diverse physiological roles OR51E1 and OR51E2, initially assumed to be GPCRs only expressed in prostate tissue, play a role in prostate In the skin, OR51E2 was shown to play a role in human melanocyte homeostasis (Gelis L. et. al 2016) and
- 📰 GPCR Weekly News - January 2 to 8, 2023
Sciences Senior Scientist, Drug Metabolism and Pharmacokinetics PhD Opportunity - Investigation Of The Role
- 📰 GPCR Weekly News
GPCRs in Neuroscience Role of G-Proteins and GPCR-Mediated Signalling in Neuropathophysiology. A robust antibody discovery platform for difficult-to-express G protein-coupled receptors. Lipid Modulation of a Class B GPCR: Elucidating the Modulatory Role of PI(4,5)P2 Lipids.
- 📰 GPCR Weekly News
Therapeutics strengthens Scientific Advisory Board with appointment of immuno-oncology experts More millions roll
- Transmembrane domains of GPCR dimers – a novel hot spot for drug discovery
Different models of dimer formation have been described for different receptors such as the ‘rolling specificity of transmembrane peptides will provide a better understanding of the physiopathological role
- Therapeutic validation of an orphan G protein‐coupled receptor
Orphan GPCRs have been shown to play key roles in various physiological functions, such as sensory perception
- Ode to GPCRs
BIOGRAPHICAL MEMOIRS OF FELLOWS OF THE ROYAL SOCIETY 70, 23–40 (2021). https://royalsocietypublishing.org Martin Rodbell – Facts - NobelPrize.org. https://www.nobelprize.org/prizes/medicine/1994/rodbell/facts Martin Rodbell – Nobel Lecture - NobelPrize.org. https://www.nobelprize.org/prizes/medicine/1994/rodbell Robert J. Non-traditional roles of G protein-coupled receptors in basic cell biology.
- The Gluopsins: Opsins without the Retinal Binding Lysine
The pipeline compiles and aligns sequences from public sources, reconstructs the phylogeny, prunes rogue
- GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral...
shown to modulate planar cell polarity in gastrulating zebrafish, but its biochemical properties and role Thus, the basolateral protein GPR125, an autocleavable adhesion GPCR, appears to play a crucial role
- Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling
November 2022 "Adhesion G-protein-coupled receptors (aGPCRs) play key roles in a diversity of physiologies
- Emerging approaches for decoding neuropeptide transmission
November 2022 "Neuropeptides produce robust effects on behavior across species, and recent research has
- Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...
This review delivers a concise overview of the role of β-arrestins with a primary emphasis on the signaling
- Activation of the human chemokine receptor CX3CR1 regulated by cholesterol
structures is observed in CX3CR1, which may correlate with three cholesterol molecules that play essential roles