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138 items found for "Wnt pathway inhibition"
- Ascitic Shear Stress Activates GPCRs and Downregulates Mucin 15 to Promote OvarianCancer Malignancy
Together, this study suggests inhibition of the Gαq protein and restriction of ascites accumulation as
- Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation
of tailfin injury, we demonstrated that antisense morpholino-mediated knockdown of blt2a or chemical inhibition
- GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression
Consequently, Gpr176 acts in a profibrotic manner, and inhibiting its activity could potentially prevent
- Delivery of US28 by incoming HCMV particles rapidly attenuates Akt activity to suppress HCMV lytic replication in monocytes
Inhibiting the dual phosphorylation of Akt prevented the lytic replication of US28Δ, and ectopic expression
- Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4
Delta-like-4 (DLL4), was strikingly downregulated upon GPR81 KD, and DLL4 KD elicited spheroid necrosis and inhibited
- Elucidation of active components and target mechanism in Jinqiancao granules for the treatment of prostatitis and benign prostatic hyperplasia
Nitric acid (NO) inhibition was tested on the macrophage cell line RAW264.7. Seventeen compounds showed NO inhibitory activity.
- Session III | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
My expertise lies in exploring the biological properties and signaling pathways activated by aGPCRs,
- Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity
As a consequence of natural posttranslational modifications, human CXCL10 exhibits a high degree of structural Moreover, CXCL10(1-73) exhibited an attenuated capacity to induce CXCR3A-mediated signaling, as evidenced In contrast, loss of the four endmost C-terminal residues did not affect the inhibitory properties of
- Session V | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
By directly scanning and comparing energetic sequences of reaction steps, the most likely pathway and
- Ep 126 with Dr. Françoise Bachelerie
WHIM syndrome) and in the innate control of the life cycle of papillomavirus, which are commensal inhabiting
- Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia
response prediction demonstrates high accuracy in predicting sensitivity to some drug classes, such as MEK inhibitors
- Sponsorship Prospectus for Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Complimentary exhibition booth in a prominent location at the event venue. Complimentary exhibition booth at the event. Complimentary registration for 2 representatives.
- Identification of S1PR4 as an immune modulator for favorable prognosis in HNSCC through machine learning
prognosis in HNSCC through machine learning Published date September 15, 2023 Abstract "The multikinase inhibitor
- Bispecific antibodies targeting BCMA or GPRC5D are highly effective in relapsed myeloma after CAR T-cell therapy
talquetamab (n = 28), teclistamab (n = 37), combinations of immunomodulating drugs (IMiDs), proteasome inhibitors
- Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach
Our results indicate that two-thirds of tested cores exhibit clinically significant expression of at
- Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
We confirmed the elevated RGS16 protein level in CRC, and found that patients with RGS16-high tumors exhibited
- Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation
Gpr101 on macrophages disrupted host pro-resolving responses to zymosan challenge with MacGpr101KO mice exhibiting
- Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic diseases
, Interleukin-33 receptor , Interleukin-4 receptor alpha , Interleukin-5 receptor alpha , JAK , JAK inhibitors
- Evolutionary diversity of CXCL16-CXCR6: Convergent substitutions and recurrent gene loss in sauropsids
Most birds exhibit the DRL motif.
- A disturbed metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A in macrophages
These patients also exhibited upregulated expression of most metabolite-sensing GPCRs analysed, which
- Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell carcinoma: an emerging prognostic indicator and future therapeutic target
Results: Out of the total of 65 OSCC tissues, 41 tissues (63.1%) exhibited high expression for β2-AR
- Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis
RGS14 exhibited seven significantly tolerant and seven significantly intolerant residues, RGS10 had six
- Exploration of prognostic and treatment markers in hepatocellular carcinoma via GPCR-related genes analysis
Patients in the high-risk group exhibited a worse prognosis but demonstrated a more favorable immunotherapy
- Ep 142 with Dr Claudia Stäubert
, with Claudia concluding that diseases might first affect the metabolites and not necessarily lack inherited
- Classified News | Dr. GPCR Ecosystem
holo-adhesion GPCR function Read More September 25, 2024 The G Protein-Coupled Receptor GPR56 Is an Inhibitory
- The Effect of Cancer-Associated Mutations on Ligand Binding and Receptor Function - A Case for the 5-HT2C Receptor
The inhibitory potency of mesulergine was increased at E306A6.30 but not E306K6.30.
