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140 items found for "Yanbin Ke"
- Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes
A blockade of 5-HT2A receptor with the preferential antagonist ketanserin prevented the receptor-mediated In adult mice, intraperitoneal ketanserin injection increased basal TrkB phosphorylation in the frontal
- Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal...
using a combination of experimental and simulation approaches, that membrane cholesterol acts as a key
- Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
September 2022 "The glucagon-like peptide-1 receptor (GLP-1R) plays a key role in metabolism and is an Given the high induction of GLP-1R in human iTreg cells, we hypothesize that GLP-1R+ iTreg cells play a key
- Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors
We verified the role of some key residues in the dynamic recognition of naloxone and morphine and identified the key residue I322, which leads to differential recognition of morphine and naloxone while assisting
- Isoform-and ligand-specific modulation of adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder
are cell-surface proteins with large extracellular regions that bind to multiple ligands to regulate key
- Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota..
These data reposition key roles of the L cell-gut IEL GLP-1R axis, revealing mechanisms linking GLP-1R
- Endocannabinoid System in the Neuroendocrine Response to Lipopolysaccharide-induced Immune Challenge
September 2022 "The endocannabinoid system plays a key role in the intersection of the nervous, endocrine
- PI(4,5)P 2-stimulated positive feedback drives the recruitment of Dishevelled to Frizzled in Wnt-β-c
plasma membrane recruits the β-catenin destruction complex, enabling the phosphorylation of LRP5/6, a key
- Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epith
Network in the Intestinal Epithelium That Directs P-Glycoprotein Expression "P-glycoprotein (P-gp) is a key
- Upregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic Response
September 2022 "The activation of phospholipase C (PLC) is thought to have a key role in the cardiomyocyte
- Targeted Therapies to Reduce Side Effects in Modern Drug Development
It is necessary for drugs to evaluated for potential toxicities and side effects, and these key factors
- Effects of Small Molecule Ligands on ACKR3 Receptors
characteristics that determine the ability of small molecules to activate ACKR3 receptors, revealing a key
- A new Kunitz-type snake toxin family associated with an original mode of interaction with the...
Key results: Eight additional MQs were identified with nanomolar affinities for the V2R, all antagonists
- Neurocrine Biosciences Presents Data on Treatment of Adolescent Patients with Classic Congenital ...
Patients with Classic Congenital Adrenal Hyperplasia at ENDO 2022 "06/13/22 - Substantial Reductions in Key
- Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs
2022 "G protein-coupled receptors (GPCRs) represent a major therapeutic target class as they play a key
- Inversago Pharma appoints Glenn S. Vraniak as Chief Financial Officer
Vraniak served as the Chief Financial Officer of electroCore, Inc. and was a key member of the management
- Sosei Heptares and Kallyope Enter Collaboration to Identify and Validate Novel Gastrointestinal GPCR
leverage multiple sophisticated technologies that drive creation of new drug discovery programs in key
- Targeting the M1 muscarinic receptor in neurodegenerative disease
Sophie Bradley, Translational Sciences Associate Director at Sosei Heptares , recently presented at the Keystone
- Precise druggability of the PTH type 1 receptor
Here we found a key mechanical site that modulates the collective dynamics of the receptor and used this
- GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between ...
absence of typical cell surface ligands) to control complex cellular activities implicates them as key
- The sixth transmembrane region of a pheromone G-protein coupled receptor, Map3, is implicated in ...
In particular, we demonstrated that two amino acid residues of Map3, F214 and F215, are key residues
- Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled ..
Cytokine IL-6 and Is Dependent on NF-κB Signaling G protein-coupled receptors (GPCRs) have emerged as key
- In Vitro and In Silico Characterization of Kurarinone as a Dopamine D 1A Receptor Antagonist and ...
docking displayed low binding energies during the intermolecular interactions of kurarinone with the key
- Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembra
Importantly, the agonist activity of these PAMs involves a key region in the central core of the GABAB2
- On-cell nuclear magnetic resonance spectroscopy to probe cell surface interactions
In this review, we outline some key NMR techniques applied for on-cell NMR studies through both solution - and solid-state NMR and survey studies that have used these techniques to uncover key information.
- Finding needles in haystacks: Omass unveils pipeline aimed at tough-to-drug targets
yet proof of the pudding, but Omass Therapeutics Ltd.’s new structure-based technology has passed a key
- Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in ...
pSS) remains unknown, and there is no ideal drug for the specific treatment of pSS. β-arrestin2 is a key
- Functional molecular switches of mammalian G protein-coupled bitter-taste receptors
The experimental structure of these receptors has yet to be determined, and key-residues controlling