If you'd like to showcase your work, please email us at Hello@DrGPCR.com. We would also like to take a moment to thank the organizers for inviting Dr. GPCRs in Oncology and Immunology A2aR on lung adenocarcinoma cells: A novel target for cancer therapy Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration 15, 2023) GPCRs in drug discovery: challenges & solutions (June 19 - 23, 2023) Training School on “Cell-based

GPCRs in Cardiology, Endocrinology, and Taste SOCS3 inhibits the mesenchymal stromal cell secretory factor Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer Updates in GPCR Research Profiling of basal and ligand-dependent GPCR activities by means of a polyvalent cell-based

Genomic Activity of an EP4-Receptor and β2-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Cells GPCRs in Oncology and Immunology Unveiling G-protein coupled receptors as potential targets for ovarian cancer cannabinoid CB2 heteromer Mechanistic insights from the atomic-level quaternary structure of short-lived GPCR oligomers in live cells Industry News Confo Therapeutics Announces EUR 60M Series B Financing to November 5 - 7, 2024 | 16th Annual PEGS Europe   September 18, 2024 | FREE Webinar - The value of GPCR cell-based

Indicators Design of an effective small expression tag to enhance GPCR production in E. coli-based cell-free and whole cell expression systems A high-throughput structural dynamics approach for identification 2 Study Completes Recruitment of Patients Sanyou Bio's Evolution of Bioprocess Enhancement for CHO Cell Lines: A Talk by Dr. TRUQAP™ (capivasertib) plus fulvestrant approved in the US for patients with advanced HR-positive breast cancer

al. for their fantastic work on Germline mutations in a G protein identify signaling cross-talk in T cells 🌟 Exciting news - the complete agenda is live; check it out HERE ! in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell GPCR Activation and Signaling Germline mutations in a G protein identify signaling cross-talk in T cells in a mouse model of sciatic nerve injury GPCRs in Oncology and Immunology GPR37 promotes colorectal cancer

Methods & Updates in GPCR Research The Road to Quantitative Lipid Biochemistry in Living Cells. GPCR Events, Meetings, and Webinars NEW AACR 2023 - American Association for Cancer Research (April 14 (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Jobs Convergent Research - Senior Scientist, Cell-Based

via cross-motif signaling from Gq to adenylyl cyclase in intrinsically photosensitive retinalganglion cells GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment. Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling GPCR Research Quantitation of Plasma Membrane (G Protein-Coupled) Receptor Trafficking in Cultured Cells Cells.

of the Year at the Citeline Japan Awards 2024 GPCR therapies: Eight promising biotechs hacking the cell in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell Approaches Altered PLCβ/IP3/Ca2+ Signaling Pathway Activated by GPRCs in Olfactory Neuronal Precursor Cells ) The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells Methods & Updates in GPCR Research Generation of CRISPR/Cas9 modified human iPSC line with correction

October 2022 Mechanism of enhanced sensitivity of mutated β-adrenergic-like octopamine receptor to amitraz Previous assays verified that a typical G protein-coupled receptor, β-adrenergic-like octopamine receptor

October 2022 "While the role of G-protein-coupled receptors (GPCR) in cancer is acknowledged, their underlying demonstrate identification of a pleckstrin-homology (PH)-binding motif within PAR4, critical for colon cancer EGFR/erbB is among the most prominent cancer targets. Overall, our studies are expected to allocate new targets for cancer therapy. Pc(4-4) may become a promising candidate for future therapeutic cancer treatment."

Sukhtankar and Pina M Cardarelli's research: Burixafor Hydrobromide (GPC-100) effects on hematopoietic cells GPR84 GPCR Binders, Drugs, and more Computational Peptide Design Cotargeting Glucagon and Glucagon-like -100), a Novel C-X-C Chemokine Receptor 4 Antagonist and Mobilizer of Hematopoietic Stem/Progenitor Cells fibroblast heterogeneity in fibroblast-associated diseases Ultrasensitive dose-response for asbestos cancer Research Collaboration Addex Therapeutics To Release Half-Year 2023 Financial Results And Host Conference Call

therapeutically exploit GPCRs (Physiology’s ‘Swiss Army Knife’) vast repertoire of ways to control cell Let's make your brand shine like never before! in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell by sphingosine kinase-1 GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells transcriptomic atlas of enteroendocrine cells along the murine gastrointestinal tract Intracellular

GPCR Activation and Signaling Cell death signaling in Anopheles gambiae initiated by Bacillus thuringiensis back again: the lysophosphatidic acid-CCN axis in signal transduction NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling CCR7 acts as both a sensor and a sink for CCL19 Global Healthcare Conference CEO Raymond Stevens to Speak at STAT Future Summit on Obesity Therapeutics Call

cells expressing the target receptor. cell. for a number of inflammatory diseases including atherosclerosis, scleroderma, multiple sclerosis and cancer Figure 5: In an in vitro functional signaling assay on a human monocytic cell line, OB-004 demonstrated and efficiently advance a diversified portfolio of GPCR-targeted drug candidates for the treatment of cancer

Find speaker details on the Live Talks page and mark your calendar HERE. Regulation of Cardiomyocyte Rac1 Signaling Activity and Minor Effects on Cardiac Hypertrophy Single cell and Immunology Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer Cells. Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways Spliceosome mutations are associated

Oncology and Immunology Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis Methods & Updates in GPCR Research Modulating signalling prediction using a protein language model Reviews, GPCRs, and more Potential of olfactory neuroepithelial cells

You can now watch the live talk recordings from the previous symposiums, check them out here. Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells intertwining roles of caveolin, oxytocin receptor, and the associated signalling pathways in prostate cancer 2023) NEW GPCRs in drug discovery: challenges & solutions (June 19 - 23, 2023) Training School on “Cell-based

adhesion G protein-coupled receptors as potential therapeutic targets in Uterine Corpus Endometrial cancer The structure, function, and involvement of adhesion GPCRs in cancer development have been discussed

Erythrocytes are terminally differentiated anuclear cells with no transcription and limited translation Additionally, ACKR1 expression characterizes venular endothelial cells (ECs) ( Pruenster et al., 2009 ; Thiriot et al., 2017 ), including those lining bone marrow (BM) sinusoids ( Duchene et al., 2017 ) This well-established, distinctive pattern of cell expression has been directly challenged by a publication and ECs, suggesting that macrophage ACKR1 engages its non-cognate ligand CD82 on hematopoietic stem cells

4256, a Highly Potent and Selective Inhibitor of GPR65, in Presentation at American Association for Cancer (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion Scientist - Antibody Engineering NEW Scientist—Immuno-Oncology Convergent Research - Senior Scientist, Cell-Based

Special Offer for Scientists who work and live in developing countries If you live and work in a developing Nominated for Prestigious Prix Galien USA ‘Best Startup’ Award: Pioneering GPCR-Driven Immunotherapies in Cancer Adiso Announces Groundbreaking Research Highlighting ADS024 a Novel Oral Agent for Neuroinflammation Call , 2024 | 4th Transatlantic ECI GPCR Symposium September 18, 2024 | FREE Webinar - The value of GPCR cell-based future directions Going rogue: mechanisms, regulation, and roles of mutationally activated Gα in human cancer

Hoare's workshop for individuals who live and work in developing countries.  Kv7 channels via Gi/o protein signalling and modulates excitability of human induced pluripotent stem cell-derived nociceptive-like neurons Characterization of myoinhibitory peptide signaling system and its implication Deciphering a GPCR-lncRNA-miRNA Nexus: Identification of an Aberrant Therapeutic Target in Ovarian Cancer Methods & Updates in GPCR Research Alared: Solvatochromic and Fluorogenic Red Amino Acid for Ratiometric Live-cell

receptor 5 (mGluR5), can lead to sustained calcium signaling and activation of transcription factors like positioning of the cannabinoid CB1 receptor on the outer mitochondrial membrane of skeletal and myocardial cells The clinical relevance of understanding these signaling mechanism is linked with the fact that dysregulation For instance, aberrant endosomal signaling by GPCRs has been linked to disorders such as cancer, neurodegenerative GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic

adhesion GPCR dissociation GPCR Activation and Signaling GPR101: Modeling a constitutively active receptor linked to X-linked acrogigantism The mechanism of Gαq regulation of PLCβ3-catalyzed PIP2 hydrolysis GPCR Binders Microbiota Effects on the Immune System, and Western Diseases Lactate receptor GPR81 drives breast cancer structural conservation across distant species Industry News Avantor's (AVTR) New Offerings to Aid Cell and Gene Therapy Suite Avantor® Expands Cellular Science Offerings with Multispan Cell Engineering and

Take 2 minutes to fill out this survey and let us know what you liked, what you didn’t, and what we can Comparative interactome analysis of α-arrestin families in human and Drosophila Functional diversification of cell parahaemolyticus Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer analysis of Gi-coupling receptors via engineered Gt and Nb35 application Imaging GPCR Dimerization in Living Cells with Cucurbit[7]uril and Hemicyanine as a "Turn-On" Fluorescence Probe Industry News Domain Therapeutics

this study was to evaluate the role of GPR21 in human macrophages, analyzing (i) its involvement in cell THP-1 cells were activated and differentiated into either M1 or M2 macrophages. Cell migration was detected by the Boyden chamber migration assay, performed on macrophages derived from both the THP-1 cell line and human peripheral blood monocytes."

Congratulations to the GPCR Therapeutics team for their publication on improving hematopoietic stem cell Activation and Signaling The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function GPCR Binders, Drugs, and more GPC-100, a novel CXCR4 antagonist, improves in vivo hematopoietic cell mobilization when combined with propranolol Discovery

expansion to enable site-specific bioorthogonal labeling of functional G protein-coupled receptors in live cells. Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration. (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference.