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157 items found for "cancer immune checkpoints"
- Ep 75 with Vaithish Velazhahan
His undergraduate thesis work on studying the biochemical mechanisms of flavonoids in cancer using nuclear
- Ep 157 with Dr. Nagarajan Vaidehi
She is also the Associate Director of the City of Hope Comprehensive Cancer Center. Dr.
- GPCR Retreat Schedule 2023
November 3rd / 3:00 PM Coffee Break 4 Read More Friday, November 3rd / 3:30 PM G Proteins and GPCRs in Cancer 3rd / 3:55 PM Inhibition of Relaxin Autocrine Signaling Confers Therapeutic Vulnerability in Ovarian Cancer Rasmussen Rockefeller University Read More Friday, November 3rd / 4:35 PM Targeting adenosine signaling for immuno-oncology
- Severity of neurological long-COVID symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic nervous system receptors
pathogenesis of Long-COVID is currently under heavy scrutiny and existing data on the role of auto-immune
- C5aR2 receptor: The genomic twin of the flamboyant C5aR1
is a classical G-protein-coupled receptor (GPCR), whereas C5aR2 is a nonclassical GPCR that tailors immune
- GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment
Lorazepam, which has off target agonism of GPR68, is linked to worse clinical outcomes for a variety of cancers However, the role of tumor microenvironment acidification in GPR68 activation has not been assessed in cancer
- Characterization, expressional and evolutionary analysis of five fish-specific CCRs (CCR4La, CCR4Lc, CCR12a1, CCR12a2, and CCR12b) in largemouth bass (Micropterus salmoides)
CCRs were significantly induced in spleen of largemouth bass, indicating their important roles in the immune
- Ep 136 with Murat Tunaboylu & Ben Holland
After switching to biotech, Murat has built cell imaging software and lab robots to accelerate cancer
- GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium
November 1, 2022 Abstract The rheumatoid arthritis (RA) inflammatory process occurs in the joints where immune
- A disturbed metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A in macrophages
Disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract characterized by disrupted immune
- Molecular docking and dynamics simulation studies uncover the host-pathogen protein-protein interactions in Penaeus vannamei and Vibrio parahaemolyticus
Hence, this study was conducted to identify the interaction sites and binding affinity between several immune-related
- Ep 92 with Dr. Stephane Angers
development of novel antibody molecules blocking and activating the Wnt pathway for the treatment of cancers
- Student Flash Presentations | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Role Of GPR97/ADGRG3 In Neutrophil Biology Tyler Bernadyn Next Generation MBD2 inhibitors for Brain Cancer Formation in Li-Fraumeni Syndrome Alex Torrelli-Diljohn Abstract "Li-Fraumeni syndrome (LFS) is a rare cancer El Merahbi Rabih, Herzig Stephan , Georgiadi A , Helmholtz Center Munich, Institute of Diabetes and Cancer Research Group to identify novel prognostic biomarkers and therapeutic options for Metastatic Breast Cancer Tyler Bernadyn on the web LinkedIn Next Generation MBD2 inhibitors for Brain Cancer Therapy Jesse Stillwell
- Ep 150 with Dr GPCR Team
As a young researcher fascinated by chemokine receptors, molecular pharmacology, drug discovery, and immuno-oncology During that time, I investigated the effect of lung cancer-related mutations in the GAIN domain of the
- High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro
Previous studies have indicated that GPR50 could protect against breast cancer development and decrease
- GPCRs and fibroblast heterogeneity in fibroblast-associated diseases
such as idiopathic pulmonary fibrosis, cardiac fibrosis, pancreatic fibrosis, hepatic fibrosis, and cancer
- Distinct sub-cellular signal propagation as a component of functional selectivity
of Biochemistry and Molecular Medicine and the CEO of the Institute for Research in Immunology and Cancer
- Dynamic Phosphoproteomics of BRS3 Activation Reveals the Hippo Signaling Pathway for Cell Migration
The lung cancer cell line H1299-BRS3 was treated with MK-5046, an agonist of BRS3, for different durations
- A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
kinases AKT and CHK1 and the transcriptional regulators cMYC and STAT3 and by increasing the abundance of cancerous
- Unveiling Non-Canonical Functions for Gαq Signaling Pathways
(GRK2), a known regulator of Gq-GPCR signaling in HNSCC tumor progression (International Journal of Cancer
- "Have a nice weekend, and I'll see you tomorrow!": RAMP-interacting GPCR Pathways
Caron on the web UNC-Chapel Hill Department of Cell Biology and Physiology UNC Lineberger Comprehensive Cancer
- Ep 43 with Dr. Stuart Maudsley
At the MRC he developed novel prostate cancer therapeutics based upon his research into GPCR pluridimensional
- S1P Signaling Genes as Prominent Drivers of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia
genes are promising therapeutic targets and plausible new innovation avenues to combat IM resistance in cancer
- Ep 72 with Dr. Stuart Maudsley
At the MRC he developed novel prostate cancer therapeutics based upon his research into GPCR pluridimensional
- Ep 78 with Dr. Stuart Maudsley
At the MRC he developed novel prostate cancer therapeutics based upon his research into GPCR pluridimensional
- Coronavirus Porcine Epidemic Diarrhea Virus Utilizes Chemokine Interleukin-8 to Facilitate Viral Replication by Regulating Ca2+ Flux
These findings provide a better understanding of the role of IL-8 in PEDV-induced immune responses, which
- Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation
Earlier study demonstrated that pharmacological activation of GPR110 in both central and peripheral immune
- Ep 151 with Dr GPCR Board
control cell signaling by protease-activated receptors (PARs) and the impact on vascular inflammation and cancer research has focused on PAR1, which has important functions in hemostasis, thrombosis, inflammation, and cancer