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312 items found for "cell biology"

  • 📰 GPCR Weekly News, February 13 to 19, 2023

    GPCR Activation and Signaling Statins inhibit protein kinase D (PKD) activation in intestinal cells and The spatial distribution of GPCR and Gβγ activity across a cell dictates PIP3 dynamics. Artificial Intelligence for Drug Discovery Call for GPCR Papers GPCRs: Signal Transduction. SLAS 2023 B Building Biology in 3D Symposium. Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.

  • 📰 GPCR Weekly News, April 3 to 9, 2023

    Methods & Updates in GPCR Research The Road to Quantitative Lipid Biochemistry in Living Cells. SLAS 2023 Building Biology in 3D Symposium. Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Jobs Convergent Research - Senior Scientist, Cell-Based

  • 📰 GPCR Weekly News, May 1 to 7, 2023

    Characterization of serotonin-5-HTR1E signaling pathways and its role in cell survival. Industry News Addex Therapeutics to Release Q1 2023 Financial Results and Host Conference Call on May Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion Scientist - Antibody Engineering Scientist—Immuno-Oncology Convergent Research - Senior Scientist, Cell-Based

  • Chemokine receptor-targeted drug discovery: progress and challenges

    The involvement of chemokines and their receptors in several aspects of cancer biology, represents a for the treatment of mycosis fungoides or Sézary syndrome in adults which are subtypes of cutaneous T-cell Redundancy can be exemplified by the tumor infiltration of Treg cells which can be driven directly by different chemokines are able to activate different pathways, which can also vary depending on the cell surface (Mack et al. 1998), CCR3 is partially restored to the cell surface and partially targeted to

  • 📰 GPCR Weekly News, March 27 to April 4, 2023

    Statins inhibit protein kinase D (PKD) activation in intestinal cells and prevent PKD1-induced growth Dietary compounds activate an insect gustatory receptor on enteroendocrine cells to elicit myosuppressin A Vaccinia-based system for directed evolution of GPCRs in mammalian cells. - leadXpro and InterAx part of Fujitsu CaaS GPCR Events, Meetings, and Webinars SLAS 2023 Building Biology Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.

  • Dynamic GPCR activation revealed through time-resolved Cryo-EM

    Human cells express over 800 G-protein-coupled receptors (GPCRs) to facilitate communication with the Capturing the dynamics of GPCR activation has always been a challenge because G protein activation in cells This research not only deepens our understanding of a key biological process but also provides a valuable This highlights the power of advanced imaging techniques like cryo-EM in solving complex biological puzzles Beyond GPCRs, the methods and insights from this study can be applied to other fast, transient biological

  • Class B1 GPCR Dimerization: Unveiling Its Role in Receptor Function and Signaling

    receptors (GPCRs) are membrane-bound proteins that sense external stimuli and relay signals inside the cell (SecR)[6] and GLP-1R [7], while GLP-1R is also known to heterodimerize with the GIPR in recombinant cell This insight not only enhances our understanding of class B1 GPCR biology but also opens new avenues Current Opinion in Structural Biology, 2023. 80 : p. 102574. 2.         

  • Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84

    Expression of GPR84 is strongly up regulated in immune cells in a range of pro-inflammatory settings , recent developments and use of GPR84 pharmacological tool compounds to study its broader role and biology

  • Job Opportunity Spotlight #1: Principal Scientist, In Vitro Pharmacology

    few years ago by some former colleagues and their description of the company was very intriguing: a biology Someone with strong assay development skills as well as strong data analysis and interpretation skills Beth:  “We focus on biochemical, cell based, and radioligand binding assays to enable SAR, MOA, lead Top candidates will have a solid foundation in GPCR pharmacology as well as some experience in drug discovery Beth:  “Well, I enjoy training and mentoring team members. 

  • Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice

    receptor-binding and signaling potencies for such ligands when assessed on rodent vs human PTH1Rs, as shown by cell-based Expression is directed by the endogenous mouse promoter and hence occurs in all biologically relevant cells and tissues and at appropriate levels. PTH analog peptides that are consistent with a fully functional human PTH1R in target bone and kidney cells

  • 📰 GPCR Weekly News, October 16 to 22, 2023

    Sakmar and his team used 'bioluminescence resonance energy transfer to measure cell-surface expression of neurodegenerative diseases GPCRs in Neuroscience Primary cilia control oligodendrocyte precursor cell Preclinical Data for AI-designed LSD1 and MALT1 Inhibitors at ESMO 2023 Restoring the function of a human cell surface protein in yeast cells Trevena Reports Favorable TRV045 Topline Safety and Tolerability Data vitro pharmacology - Crinetics Pharmaceuticals In vivo Antibody Discovery Research Scientist In Vitro Biologist

  • 📰 GPCR Weekly News, January 15 to 21, 2024

    podocytopathy in kidney disease Hepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation GPCRs in Oncology and Immunology The orphan G protein-coupled receptor 141 expressed in myeloid cells with advanced gastroenteropancreatic neuroendocrine tumors Neurocrine Biosciences Announces Conference Call Pharmacology 2026 GPCR Jobs NEW Post-Doc position NEW Lead Researcher Senior Researcher in Structural Biology Fellow Research Laboratory Specialist Associate Postdoctoral Scientist Principal Investigator, In Vitro Biology

  • 📰 GPCR Weekly News

    FFAR4 improves the senescence of tubular epithelial cells by AMPK/SirT3 signaling in acute kidney injury Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells. Establishment of a CaCC-based Cell Model and Method for High-throughput Screening of M3 Receptor Drugs Oligomerization of the heteromeric γ-aminobutyric acid receptor GABAB in a eukaryotic cell-free system Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.

  • Pharmacophore-guided Virtual Screening to Identify New β 3 -adrenergic Receptor Agonists

    Therefore, this study aimed to conduct prospective virtual screening and confirm the biological activity Out of 35 tested compounds, 4 compounds were active in CHO-K1 cells expressing the human β3 -AR, and 8 compounds were active in CHO-K1 cells expressing the mouse β3 -AR."

  • 📰 GPCR Weekly News

    via cross-motif signaling from Gq to adenylyl cyclase in intrinsically photosensitive retinalganglion cells GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment. GPCR Research Quantitation of Plasma Membrane (G Protein-Coupled) Receptor Trafficking in Cultured Cells Expansion To Enable Site-Specific Bioorthogonal Labeling of Functional G Protein-Coupled Receptors in Live Cells Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.

  • 📰 GPCR Weekly News - January 9 to 15, 2023

    GPCR Allostery: a View from Computational Biology. collaborations GPCR Therapeutics Announces Launch of US Phase 2 Trial of GPC-100 in Multiple Myeloma Call SLAS 2023 Building Biology in 3D Symposium. Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. of Molecular Pharmacology, Discovery Biology Staff Scientist/Senior Staff Scientist, Disease Biology

  • 📰 GPCR Weekly News, January 8 to 14, 2024

    her team studied the GPER/GPR30 complex with β1-adrenergic receptor and AKAP5 in MCF7 breast cancer cells kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Senior Researcher in Structural Biology Fellow Research Laboratory Specialist Associate Postdoctoral Scientist Principal Investigator, In Vitro Biology

  • GPCR Updates: Celebrating Breakthroughs, New Course Launches Soon, and Exclusive Discounts! | Aug 26 - Sep 1, 2024

    Mexico City 📅 October 23-25, 2024 Join us to connect with peers and explore the latest in adhesion GPCR biology Adiso Announces Groundbreaking Research Highlighting ADS024 a Novel Oral Agent for Neuroinflammation Call for GPCR Papers Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events , 2024 | 4th Transatlantic ECI GPCR Symposium September 18, 2024 | FREE Webinar - The value of GPCR cell-based assays in drug discovery September 30 - October 3, 2024 | 22nd Discovery on Target October 2024 | Biologics

  • 📰 GPCR Weekly News, April 10 to 16, 2023

    Events, Meetings, and Webinars NEW FREE 7th ERNEST GPCR zoominar (April 20, 2023) SLAS 2023 Building Biology Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion Scientist - Antibody Engineering NEW Scientist—Immuno-Oncology Convergent Research - Senior Scientist, Cell-Based

  • Therapeutic validation of an orphan G protein‐coupled receptor

    GPR84 is a Gi‐coupled class A GPCR mainly expressed in immune cells and microglia in the brain (Wojciechowicz In this study Marsango et al. address two key questions in GPR84 biology and pharmacology: 1. how GPR84 and 2. which ligands can be used as tool compounds to study the function and biology of this receptor Regarding the first question, GPR84 overexpression in immune cells in a range of pro‐inflammatory disorders In addition, several GPR84 ligands have been described as well as GPR84 knockout mice.

  • 📰 Breaking Down the Latest GPCR Discoveries: a Weekly Update (Nov 27-Dec 3, 2023)

    receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis Methods & Updates in GPCR Research Modulating signalling prediction using a protein language model Reviews, GPCRs, and more Potential of olfactory neuroepithelial cells inspires drug research Tectonic Therapeutic Announces Start of First Clinical Program for GPCR-Targeted Biologic

  • 📰 GPCR Weekly News, May 8 to 14, 2023

    Industry News InterAx Biotech to Apply its Leading AI and Cell Signalling Technology to Support Target Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion Scientist - Antibody Engineering Scientist—Immuno-Oncology Convergent Research - Senior Scientist, Cell-Based

  • 📰 GPCR Weekly News, April 17 to 23, 2023

    Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion Scientist - Antibody Engineering Scientist—Immuno-Oncology Convergent Research - Senior Scientist, Cell-Based

  • 📰 GPCR Weekly News, August 28 to September 3, 2023

    GPCR Activation and Signaling Cell death signaling in Anopheles gambiae initiated by Bacillus thuringiensis again: the lysophosphatidic acid-CCN axis in signal transduction NPFF stimulates human ovarian cancer cell Global Healthcare Conference CEO Raymond Stevens to Speak at STAT Future Summit on Obesity Therapeutics Call Exhibition June 2 - 4, 2024 | Chemotactic Cytokines GPCR Jobs Researcher / Senior Researcher in Structural Biology

  • 📰 GPCR Weekly News, November 13 to 19, 2023

    Endosomal signaling via cAMP in parathyroid hormone (PTH) type 1 receptor biology β-arrestin1 is an E3 Indicators Design of an effective small expression tag to enhance GPCR production in E. coli-based cell-free and whole cell expression systems A high-throughput structural dynamics approach for identification 2 Study Completes Recruitment of Patients Sanyou Bio's Evolution of Bioprocess Enhancement for CHO Cell

  • Canonical chemokine receptors as scavenging “decoys”

    The immune system depends on chemokines to direct cell migration during immune surveillance and inflammation CCR2 is an example of a dual-function receptor that directly regulates both cell migration and scavenging Scavenging allows cells to continuously migrate by remaining responsive to chemokines, it dampens the , and CCR5 switch purely to scavenging (D'Amico G. et al. 2000), becoming incapable of promoting cell migration, a phenomenon which is likely to be mediated by changes in the cell motility machinery with

  • Isoform-and ligand-specific modulation of adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder

    September 2022 "Adhesion G protein-coupled receptors (aGPCRs) are cell-surface proteins with large extracellular regions that bind to multiple ligands to regulate key biological functions including neurodevelopment

  • Harnessing Deep Mutational Scanning for Enhanced Drug Discovery

    resulting phenotype, researchers can identify essential domains and residues crucial for the protein's biological The choice of model systems, such as yeast, bacteria, or mammalian cells, can heavily influence the method's directions will likely focus on enhancing its scalability, accuracy, and applicability across broader biological Another promising development is the application of DMS to a wider array of biological systems, including multicellular organisms and human cells, to better mimic physiological conditions and disease states

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