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301 items found for "cell biology"
- Structural Basis for the Recognition of GPRC5D by Talquetamab, a Bispecific Antibody for Multiple Myeloma
MM) is a complex hematological malignancy characterized by abnormal antibody production from plasma cells G-protein-coupled receptor class C group 5 member D (GPRC5D), an orphan GPCR predominantly expressed in MM cells Talquetamab, a Food and Drug Administration-approved T-cell-directing bispecific antibody developed for talquetamab Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- In Silico Design of Novel RGS2-Galpha-q Interaction Inhibitors with Anticancer Activity
Docking of identified hits to RGS2 as well as other RGS structures was used to screen the hits for potent Whole cell assays showed the top 10 ranking compounds, AJ-1-AJ-10, to inhibit RGS2-Gαq interactions. All 10 compounds inhibited the growth of several RGS2 expressing cancers in cell culture assays. In addition, AJ-3 inhibited the migration of LNCaP prostate cancer cells in wound healing assays. M Mahfouz Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis
elevated in multiple cancers, and quantitative proteomic and RNA profiling of exosomes in human cancer cell studies in mice, we show that GPR143 promotes metastasis by secreting exosomes and increasing cancer cell provide a mechanism for regulating the exosomal proteome and demonstrate its ability to promote cancer cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression
Furthermore, fibroblasts abundantly expressed Gpr176 compared to alveolar epithelial cells, endothelial cells, and macrophages in the fibrotic lung. GPR176 expression was unaffected by TGFβ1 stimulation in rat renal fibroblast NRK-49 cells, whereas knockdown of Gpr176 by siRNA reduced TGFβ1-induced expression of αSMA, fibronectin, and collagen as well as Smad2 GPCR , TGFβ1 Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer
treating patients suffering from lung cancer is to target surface receptors overexpressed on tumor cells cancers, such as prostate and ovarian cancer, facilitating the invasive and metastatic capacity of tumor cells The expression levels of KLKs in this neoplasm are modulated by the secretome of the different cell types SARS-CoV-2 Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- The power of many: Multilevel targeting of representative chemokine and metabolite GPCRs in personalized cancer therapy
cancer therapy Published date September 12, 2024 Abstract "G protein-coupled receptors (GPCRs) are vital cell highlights five GPCRs able to orchestrate tumor immunobiology at three main levels: tumor immunity, cancer cell Treatment Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Ep 147 with Dr. Demet Araç
Demet Araç "Demet was an undergraduate at Bilkent University in Turkey, where she majored in Molecular Biology Axel Brunger’s lab at Stanford University to study the structure and function of cell-adhesion proteins independent research career at the University of Chicago within the Department of Biochemistry and Molecular Biology Demet, who had studied various subjects including chemistry, physics, biology, and math, shared his interest Demet shared that his interest in science led him to study biology, genetics, and molecular biophysics
- Classified News | Dr. GPCR Ecosystem
Adhesion GPCRs September 25, 2024 The G Protein-Coupled Receptor GPR56 Is an Inhibitory Checkpoint for NK Cell BRET-Based Sensors Shed Light on Cellular Signaling Read More Read more articles from our Contributors Call for GPCR papers August 29, 2024 Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology
- GPCR Retreat | Dr. GPCR Ecosystem
Sponsors GPCR Retreat The GPCR Retreat focuses on advances in our understanding of how GPCRs operate in cell investigators from academia and industry to discuss and debate existing and novel concepts in GPCR biology
- Itaconate in host inflammation and defense
Immunology Itaconate in host inflammation and defense Published date March 5, 2024 Abstract "Immune cells Itaconate (ITA) rapidly accumulates to high levels in myeloid cells under infectious and sterile inflammatory itaconate Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- G protein-coupled receptor-mediated signaling of immunomodulation in tumor progression
receptors (GPCRs) are essential contributors to tumor growth and metastasis due to their roles in immune cell Guang-Hong Qiu, Bin Yu, Mei Ma Tags GPCRs , cancer immune checkpoints , cancer immunotherapy , immune cells Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- Coronavirus Porcine Epidemic Diarrhea Virus Utilizes Chemokine Interleukin-8 to Facilitate Viral Replication by Regulating Ca2+ Flux
Replication by Regulating Ca2+ Flux Published date May 29, 2023 Abstract "Chemokine production by epithelial cells coronavirus porcine epidemic diarrhea virus (PEDV) infection in African green monkey kidney epithelial cells (Vero) and Lilly Laboratories cell-porcine kidney 1 epithelial cells (LLC-PK1). Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation
Promotes Osteogenic Differentiation Published date May 30, 2023 Abstract "Objectives: Dental pulp stem cells (DPSCs) are a type of mesenchymal stem cell possessing self-renewal and multilineage differentiation Materials and methods: The viability and apoptosis of human DPSCs (hDPSCs) were determined using Cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- Ep 62 with Dr. Sai Prasad Pydi
obesity and Type 2 Diabetes (T2D) by exploring metabolically important signaling pathways in immune cells His laboratory uses knock-out and transgenic mouse models, along with different cell culture systems, to understand the role of immune cell GPCRs and their cross-talk with other insulin-sensitive tissues Sai Prasad Pydi on the web Molecular Metabolism & Cell Signaling Laboratory Website Twitter.com Research
- Prediction of survival and immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment in melanoma
Flowcytometry and Transwell assays were performed to observe the changes in cell apoptosis, metastasis and PKC via the signaling pathway of miR-19a/GRK6/GPR39/PKC, which accordingly resulted in suppressed cell apoptosis and promoted cell migration and invasion. scRNA-seq Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma
G protein-coupled receptor 56 (GPR56/ADGRG1) is a multifunctional adhesion GPCR involved in diverse biological transcriptomic, proteomic, and phosphoproteomic differential expression data of GPR56 knockdown U373-GBM cells Signaling , TG2 Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Comparison of infectious complications with BCMA-directed therapies in multiple myeloma
complications with BCMA-directed therapies in multiple myeloma Published date May 31, 2024 Abstract "B-cell-maturation-antigen single-center analysis we evaluated infectious complications after BCMA-targeted chimeric-antigen-receptor T-cell Comparing T-cell redirecting therapies, the incidence rate of severe infections was significantly lower M Lesokhin Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- G Protein-coupled Receptor-mediated Membrane Targeting of PLCγ2 is Essential for Neutrophil Chemotaxis
In response to a chemoattractant stimulation, cells lacking PLCγ2 (plcg2kd) displayed altered dynamics phosphorylation and cofilin activation; impaired dynamics of actin polymerization; and consequently, defects in cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- C5aR2 receptor: The genomic twin of the flamboyant C5aR1
classical G-protein-coupled receptor (GPCR), whereas C5aR2 is a nonclassical GPCR that tailors immune cell C5a-C5aR2 interaction compared to C5a-C5aR1, which will surely help in elaborating the currently debated biological Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- Plenary Lecture | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
, 2021, 2022; PNAS 2021, Molecular Pharmacology, 2017; Recommended by Faculty 1000, Nature Chemical Biology Advance 2021, PNAS 2023, Nature Metabolism 2023), recognition of amine containing hormones by GPCRs (Cell
- Orphan receptor GPR50 attenuates inflammation and insulin signaling in 3T3-L1 preadipocytes
G protein-coupled receptors (GPCRs) are involved in endocrine and metabolic processes as well as many increased in the adipose tissue of obese T2DM mice, while GPR50 deficiency increased inflammation in 3T3-L1 cells Furthermore, GPR50 knockout in the 3T3-L1 cell line suppressed PPAR-γ expression. Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- Full Agenda for Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
compact multidomain module of fourteen domains which regulates signaling Vasiliki Karagiannakou A single cell Axons Monserrat Avila Zozaya The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial cell GPR116 Willem Berend Post The Adhesion GPCR Latrophilin Interacts With The Notch Pathway To Control Germ Cell Role Of CELSR1 (ADGRC1) In Breast Cancer Emmanouil Kyrloglou GPR124 Mediates Adhesion Of Leukemic Stem Cells Discovery for Human Adhesion GPCRs Tyler Bernadyn Elucidating The Role Of GPR97/ADGRG3 In Neutrophil Biology
- Ep 153 with Dr Jacek Mokrosiński
Mokrosiński "Jacek is a Senior Scientist at Novo Nordisk specializing in molecular pharmacology and cell-based He works in a multidisciplinary Chemical Biology team based at the recently established US R&D hub in Originally from Łódź, Poland, Jacek completed his Master's degree in Biology, specializing in Biochemistry He is passionate about cell-based in vitro technologies to study mechanistic properties of GPCRs and They also highlighted the need for a work-life balance and the joy of a well-done job.
- Inhibition of Relaxin Autocrine Signaling Confers Therapeutic Vulnerability in Ovarian Cancer
research interests lies in the elucidation of signal transduction pathways in cancer, immune and bone cells area of interest has been the elucidation of the molecular basis for a rare autosomal human disease called The Rottapel lab has shown that 3BP2 has pleiotrophic function controlling bone homeostasis, immune cell
- Unveiling G-protein coupled receptors as potential targets for ovarian cancer nanomedicines: from RNA sequencing data analysis to in vitro validation
Subsequently, primary ovarian cancer cells derived from ascites and ovarian cancer cell lines were used , RNA-seq Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Ep 15 with Dr. Arun Shukla
Wellcome Trust DBT India Alliance Swarnajayanti Fellow & EMBO Young Investigator at the Department of Biological Jawaharlal Nehru University in India and it was during a biochemistry class where he learned about cell
- The GPCR adaptor protein Norbin controls the trafficking of C5aR1 and CXCR4 in mouse neutrophils
controlling their steady state trafficking and sometimes their agonist-induced internalisation, as well Norbin in the trafficking of endogenous C5aR1 and CXCR4 in primary neutrophils by flow cytometry and cell β-arrestin-dependent mechanism and limits the recycling of internalised C5aR1 and CXCR4 back to the cell C5a-stimulated membrane translocation of Tiam1, Vav, and PKCδ, and activation of Erk and p38 Mapk pathways, as well β-arrestin Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Ep 38 with Dr. Alexander S. Hauser
currently a postdoc as a member of the personalized medicine cluster in Copenhagen and at the Institute of Biological Alexander has a big interest in the integration of large biomedical data in genomics, structural biology and pharmacoepidemiology with innovative computational methods to gain novel insights into receptor biology Alexander had a research sabbatical with Madan Babu at the MRC Laboratory of Molecular Biology in Cambridge