inflammation is characterized by overexpression and heightened activity of type 2 cytokines, mediators and cells FeNO , Fractional exhaled nitric oxide , G-protein-coupled receptor , GPCR , Group 2 innate lymphoid cell , IL-31RA , IL-33R , IL-4Rα , IL-5Rα , ILC , ILC2 , IRF1 , IgE , Immunoglobulin E , Innate lymphoid cell immunoglobulin-like lectin 8 , Signal transducer and activator of transcription , Substance P , T helper type 2 cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

employed by these atypical 7-transmembrane receptors, combining biochemical and structural approaches with cell GPCR signaling pathways that operate within the primary cilium, a tiny antenna-shaped structure at the cell

G protein-coupled receptors (GPCRs, the largest family of human cell surface receptors) are associated The levels of GPCRRGs were examined in normal and OV cell lines using quantitative reverse-Etranscription epithelial Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

The effect of breast cancer cell-conditioned media (BC-CM) on the pro-inflammatory phenotype of VSMCs Tags Breast cancer , Regulator of G protein signaling 5 , Vascular remodeling , Vascular smooth muscle cells Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

atypical receptor ACKR3 both respond to CXCL12 but induce different effector responses to regulate cell While CXCR4 couples to G proteins and directly promotes cell migration, ACKR3 is G protein-independent single-molecule FRET Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

by decreased creatinine clearance and urea excretion and a decreased presence of regulatory T (Treg) cells increased activation of the immune system and a higher production of pro-inflammatory cytokines by T cells kidney stones Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

2022 Abstract The rheumatoid arthritis (RA) inflammatory process occurs in the joints where immune cells evaluated the expression of GPR15 and GPR15L in blood and synovial tissue samples from RA patients, as well synovial fluid and peripheral blood were analyzed for CD45+CD3+CD4+GPR15+ and CD45+CD3+CD8+GPR15+ T cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Results show that the elevated expression of UCA1 enhances cell proliferation, invasive migration, and therapy resistance in high-grade serous ovarian carcinoma cells, whereas silencing UCA1 reverses these UCA1 , lncRNA Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Her research focuses on understanding the fundamental cell biological mechanisms regulating GPCR activity Alejandra Tomas is a molecular cell biologist and Senior Lecturer at the Department of Metabolism, Digestion several years in Switzerland working on the study of membrane trafficking processes in pancreatic beta cells

In turn, due to overexpression of GPCRs on the surface of various types of cells, GPCR ligands can endow nanoparticles with active targeting capacity for specific cells via ligand-receptor binding and mediate transduction Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

FRET and single-molecule microscopy, which allow them to directly observe signalling events in living cells Davide’s work has been published in prestigious scientific journals such as Nature, Cell, New England

the orphan atypical cannabinoid receptor, GPR55 and its crosstalk with CB1R and CB2R in endothelial cells which I characterized the impact of a fungal allergenic source on the function of airway smooth muscle cells

receptors in the central nervous system and one of the key proteins for signal transduction between cells J Lawrence Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

co-founder of InterAx Biotech, where he specializes in the development of a technology platform deciphering cell explored the potential of merging mathematical models with biology, the complexities of GPCRs within cells Cell Signaling and Cancer Metastasis Discussion Aurelien Rizk and Yamina Berchiche had a detailed conversation about the intricacies of cell signaling and chemokine receptors. Yamina shared her research experience, emphasizing the fascination of understanding how cells respond

These might serve as allosteric agonists of PAR1 on endothelial cells and platelets, and thus might contribute Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Our laboratory is interested in the role of NMDA receptors not only on neurons, but also on other cells of the brain such as astrocytes, oligodendrocytes, and endothelial cells.

Eldridge Distinguished Professor and Chair of the Department of Cell Biology & Physiology at The University Kathleen Caron on the web UNC-Chapel Hill Department of Cell Biology and Physiology UNC Lineberger Comprehensive

Trejo’s research program is to gain a thorough and mechanistic understanding of processes that control cell acquired critical expertise, and rigorous approaches to examine PAR1 function using human cultured cells

P2Y12R activation can promote platelet aggregation and adhesion to cancer cells, promote tumor angiogenesis microenvironment Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

developed expertise over the past two decades studying structure/function relationships of GPCRs using live-cell Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the After a well needed break from the grind, I am now a scientific/business consultant for clients both Trejo’s research program is to gain a thorough and mechanistic understanding of processes that control cell acquired critical expertise, and rigorous approaches to examine PAR1 function using human cultured cells

focuses on understanding the molecular mechanisms of adhesion GPCRs (aGPCRs) in lymphatic endothelial cells

She has expertise in cell biology, pharmacology, translational medicine, oncology, immuno-oncology, immunology Previously, she held the position of Vice President of Cell Biology & Pharmacology, at Bristol-Myers She has extensive experience working with Biologics, and Antibody Drug Conjugates as well as experience

Simone Prömel Simone Prömel is currently a professor of cell biology at the Heinrich Heine University of action of Adhesion GPCRs and found that they do not only mediate classical G protein signals into cells

, 2023 Abstract "Macrophages release soluble mediators following efferocytic clearance of apoptotic cells macrophage Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Fan is currently an associate professor of Pharmacology and Pathology and Cell Biology at Columbia University

developed expertise over the past two decades studying structure/function relationships of GPCRs using live-cell Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the Monserrat Avila Zozaya I did a PhD in cell biology at CINVESTAV, Mexico.

Although lysophosphatidic acid was proposed to be a natural ligand for this cell surface receptor, these Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News GPCR Jobs Call

The precise mechanisms by which ACs contribute to cancer cell proliferation and invasion are not well Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR