Stay tuned for more information coming soon. Interested in showcasing your research? between renin-angiotensin system receptors Arrestin-centred interactions at the membrane and their conformational Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference

Conformational specificity of opioid receptors is determined by subcellular location irrespective of

to peptide and non-peptide ligands have been elucidated, providing new opportunities to examine the dynamic This review covers the new data elucidating the structural dynamics of AngII receptors and how structural

Activation and Signaling PACAP key interactions with PAC1, VPAC1, and VPAC2 identified by molecular dynamics cells Profiling the proximal proteome of the activated μ-opioid receptor Computational modelling of dynamic for patent granted for somatostatin modulators for treating hormone-related conditions Sosei Heptares Confirms Clinical Study Evaluating Effects of NBI-1065890, a Second-Generation VMAT2 Inhibitor, in Healthy Adults Confo 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference

Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Interface from Molecular Dynamics allosteric sites of the PAR2, C5aR1, and GCGR receptors in three lipid compositions using molecular dynamics

This reduction in cleft glutamate concentration was confirmed by imaging glutamate release using a genetic Thus, stimulus trains in 5-HT1B receptor agonist unveil dynamic synaptic modulation and a sophisticated

Our confirmed speakers are Dr. Xavier Leroy, Dr. Brian Arey, and Dr. J. Silvio Gutkind. You can find more information about them on the Live Talks page and mark your calendar HERE. deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses State-dependent dynamics I-GPCRNet November 2 - 4, 2023 | GPCR Retreat- Registration Closed November 15 - 17, 2023 | MPGPCR Conference 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference

neuron GPCRs for peripheral neuropathic pain GPCRs in Oncology and Immunology Expression prevalence and dynamics applications Imaging flow cytometry of tumoroids: A new method for studying GPCR expression GPCR molecular dynamics Function Fully activated structure of the sterol-bound Smoothened GPCR-Gi protein complex Deep Learning Dynamic Webinars January 16 - 19, 2024 | 23rd Annual PEP Talk February 3 - 7, 2024 | SLAS2024 International Conference 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference

assemblies with β-arrestin serving distinct functions Phosphorylation motif dictates GPCR C-terminal domain conformation Meetings, and Webinars November 10, 2023 | Sosei Heptares Zoom Webinar November 15 - 17, 2023 | MPGPCR Conference November 20 - 23, 2023 | ASCEPT Annual Scientific Meeting February 3 - 7, 2024 | SLAS2024 International Conference Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference

Upon activation, GPCRs have conformational changes that allow the coupling and subsequent activation

Molecular Dynamics and Machine Learning Study of Adrenaline Dynamics in the Binding Pocket of GPCR.

about State transitions of coupled Gi-protein: Insights into internal water channel dynamics within dopamine Webinars November 5 - 7, 2024 | 16th Annual PEGS Europe   NEW November 25 - 26, 2024 | 6th International Conference on Stem Cell, Tissue Engineering and Regenerat November 25 - 27, 2024 | 1st Virtual GPCR Forum Conference chemokine receptor 5 (CXCR5) State transitions of coupled Gi-protein: Insights into internal water channel dynamics structure determination Molecular Basis of MC1R Activation: Mutation-Induced Alterations in Structural Dynamics

Sosei Heptares Confirms Changes to its Board and Executive Management Team at Annual Shareholders’ Meeting 2023) NEW Webinar - Antiverse: Engineering the Future of Drug Discovery (March 30, 2023) NEW Molecular Dynamics (April 20 - 21, 2023) Swiss Biotech Day (April 24 - 25, 2023) SLAS Europe 2023 Conference and Exhibition (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. The Illuminating the Understudied Druggable Proteome Conference.

We are delighted to confirm the participation of esteemed speakers such as Drs.  Stay tuned for more information. Dr. GPR101: Modeling a constitutively active receptor linked to X-linked acrogigantism State-dependent dynamics Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference

This review aims to explore the signaling pathways, dynamic structures, and physiological relevance in

current technological landscape in which the field is operating to decode key questions regarding these dynamic

GPCR Binders, Drugs, and more Predicting allosteric sites using fast conformational sampling as guided Industry News Confo Therapeutics Enters into Collaboration Agreement with Daiichi Sankyo to Discover (April 20 - 21, 2023) Swiss Biotech Day (April 24 - 25, 2023) SLAS Europe 2023 Conference and Exhibition (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. The Illuminating the Understudied Druggable Proteome Conference.

A finely tuned signalling compartmentalization orchestrated in dynamic platforms is an essential requirement

Dynamic Learning Environment Tailored to Your Needs Maximize your learning experience by accessing our October 2024 Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) Neurocrine Biosciences Announces Conference Workshop November 5 - 7, 2024 | 16th Annual PEGS Europe   November 25 - 27, 2024 | 1st Virtual GPCR Forum Conference serotonin1A receptor Potential allosteric pockets identification of glucagon receptor based on molecular dynamics

, we investigate the effects that long-term CNO stimulatory culture have on hM3Dq [Ca2+]i signaling dynamics Long-term culturing under repeated CNO stimulation modified the temporal dynamics of hM3Dq [Ca2+]i signaling

Further molecular dynamics simulation studies reveal an interaction between the βarr2 finger loop domain

Using classical and enhanced molecular dynamics simulations, we show that membrane lipids are critical

Structural and Molecular Insights into GPCR Function Structural and dynamic insights into supra-physiological (April 20 - 21, 2023) SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. The Illuminating the Understudied Druggable Proteome Conference. PhD Project - Investigating the lipid regulation of GPCR signalling Postdoctoral Fellow - Molecular Dynamics

In this review, we discuss the relationship between structure, function, and dynamics of opioid receptors

Stay informed with our GPCR roundup. coordinate collective leukocyte migration Methods & Updates in GPCR Research 3DDPDs: describing protein dynamics Systematic review and meta-analysis Structural and Molecular Insights into GPCR Function Analysis of the Dynamics Bolsters Leadership Team as the Company Advances its Multi-Product Pipeline Toward Clinical Studies Confo 21st Annual Global Healthcare Conference CEO Raymond Stevens to Speak at STAT Future Summit on Obesity

August 2022 "Genetically encoded fluorescent biosensors allow intracellular signaling dynamics to be

microenvironment and process of EBV-induced lymphomagenesis GPR56 signaling pathway network and its dynamics production in E. coli-based cell-free and whole cell expression systems A high-throughput structural dynamics advanced HR-positive breast cancer GPCR Events, Meetings, and Webinars November 15 - 17, 2023 | MPGPCR Conference Meeting January 16 - 19, 2024 | 23rd Annual PEP Talk February 3 - 7, 2024 | SLAS2024 International Conference 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference

However, these conventional assays often provide limited information on intermediate signaling events GPCRs by enabling real-time monitoring of protein-protein interactions and intracellular signaling dynamics protein activation (e.g TRUPATH assay [9]), receptor trafficking ( e.g FYVE assay [10]),  β-arrestin dynamics