signaling: conformational dynamics and intracellular responses GPCR signaling is a complex process modulated Apart from G proteins, GPCRs engage other effectors for signaling modulation. and hydrogen-deuterium exchange (HDX) mass spectrometry for time-dependent conformational insights (Komolov tissue-specific expression, have played a pivotal role in identifying essential effector proteins that modulate

GPCR Binders, Drugs, and more Allosteric modulation of a human odorant receptor. assays allow the analysis of binding kinetics of WNT-3A to endogenous Frizzled 7 in a colorectal cancer model

of the most recent findings in human studies and contextualize them considering previous preclinical models

Xenograft mouse model was generated to investigate the in vivo efficacy of fentanyl.

high-resolution techniques to investigate peptidergic transmission and expression throughout the brain in model

most significant groups of G-protein coupled receptor (GPCR) drug targets and also act as prototypical models

Tribolium castaneum GPCR Activation and Signaling Palmitoylation of the Glucagon-like Peptide-1 Receptor Modulates Binding Methods to Measure Receptor-Ligand Interactions How accurately can one predict drug binding modes using AlphaFold models?

CCR6 for Autoimmune Diseases MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model Glycoprotein-glycoprotein receptor binding detection using bioluminescence resonance energy transfer Bayesian network models

subcellular localization and activity in a polarized epithelium using the Drosophila wing imaginal disc as a model

Our model not only shows the function of dimeric β2-AR but also provides a molecular insight into the

adenylyl cyclase (AC) Rv1625c/Cya is an evolutionary ancestor of the mammalian membrane ACs and a model

In a LPS-induced lung inflammation model in mice, ACT-660602 led to significantly reduced recruitment

CXCR1/2 inhibitors show beneficial effects in various animal models of CVD.

Our model not only shows the function of dimeric β2-AR but also provides a molecular insight into the

CXCR1/2 inhibitors show beneficial effects in various animal models of CVD.

Our data support a model wherein Smog regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent

Our data support a model wherein Smog regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent

In a mouse model of contact hypersensitivity, β-arrestin-biased CXCR3-mediated inflammation is dependent

We discuss the importance of understanding the translatability of cell and animal models to have more

In this study, we established an experimental Sjögren's syndrome (ESS) mouse model to elucidate the molecular increased saliva flow, alleviated salivary gland indices, and improved tissue integrity in the ESS model

These data lead us to a model where Kel1 promotes completion of cytokinesis before pheromone-induced

The absence of VLGR1 in tissues and cells derived from VLGR1-deficient mouse models resulted in alterations

Using shRNA knockdown and CRISPR/Cas9 knockout cell lines, as well as mouse models, we confirmed the

These data support a model where Gq and Gβγ-dependent signaling cooperatively regulate PLC activation

Moreover, the main investigations into animal models and ongoing clinical trials using these unimolecular

Nevertheless, estimates from computational modeling suggest that many of the least sensitive variants

Recently, Suchismita Roy et al. have explored how growth factors can modulate canonical G protein signaling primary research question addressed in this study was: How do growth factors, specifically through RTKs, modulate The ability of growth factors to modulate G protein signaling through specific phosphorylation events inform the development of therapeutic strategies aimed at targeting specific phosphorylation events to modulate

The structures reveal distinctive ligand engaging model and activation conformations of GPR110.