Docking of identified hits to RGS2 as well as other RGS structures was used to screen the hits for potent Whole cell assays showed the top 10 ranking compounds, AJ-1-AJ-10, to inhibit RGS2-Gαq interactions. All 10 compounds inhibited the growth of several RGS2 expressing cancers in cell culture assays. In addition, AJ-3 inhibited the migration of LNCaP prostate cancer cells in wound healing assays. M Mahfouz Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

elevated in multiple cancers, and quantitative proteomic and RNA profiling of exosomes in human cancer cell studies in mice, we show that GPR143 promotes metastasis by secreting exosomes and increasing cancer cell provide a mechanism for regulating the exosomal proteome and demonstrate its ability to promote cancer cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Furthermore, fibroblasts abundantly expressed Gpr176 compared to alveolar epithelial cells, endothelial cells, and macrophages in the fibrotic lung. GPR176 expression was unaffected by TGFβ1 stimulation in rat renal fibroblast NRK-49 cells, whereas knockdown of Gpr176 by siRNA reduced TGFβ1-induced expression of αSMA, fibronectin, and collagen as well as Smad2 GPCR , TGFβ1 Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

treating patients suffering from lung cancer is to target surface receptors overexpressed on tumor cells cancers, such as prostate and ovarian cancer, facilitating the invasive and metastatic capacity of tumor cells The expression levels of KLKs in this neoplasm are modulated by the secretome of the different cell types SARS-CoV-2 Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

of 10 kDa (IP-10/CXCL10) is a dual-function CXC chemokine that coordinates chemotaxis of activated T cells and natural killer (NK) cells via interaction with its G protein-coupled receptor (GPCR), CXC chemokine CXCL10(1-77) using surface plasmon resonance for glycosaminoglycan (GAG) binding affinity, assays for cell migration, second messenger signaling downstream of CXCR3, and flow cytometry of CHO cells and primary human T lymphocytes and endothelial cells.

In response to a chemoattractant stimulation, cells lacking PLCγ2 (plcg2kd) displayed altered dynamics phosphorylation and cofilin activation; impaired dynamics of actin polymerization; and consequently, defects in cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Promotes Osteogenic Differentiation Published date May 30, 2023 Abstract "Objectives: Dental pulp stem cells (DPSCs) are a type of mesenchymal stem cell possessing self-renewal and multilineage differentiation Materials and methods: The viability and apoptosis of human DPSCs (hDPSCs) were determined using Cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Flowcytometry and Transwell assays were performed to observe the changes in cell apoptosis, metastasis and PKC via the signaling pathway of miR-19a/GRK6/GPR39/PKC, which accordingly resulted in suppressed cell apoptosis and promoted cell migration and invasion. scRNA-seq Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

G protein-coupled receptors (GPCRs) are involved in endocrine and metabolic processes as well as many increased in the adipose tissue of obese T2DM mice, while GPR50 deficiency increased inflammation in 3T3-L1 cells Furthermore, GPR50 knockout in the 3T3-L1 cell line suppressed PPAR-γ expression. Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

complications with BCMA-directed therapies in multiple myeloma Published date May 31, 2024 Abstract "B-cell-maturation-antigen single-center analysis we evaluated infectious complications after BCMA-targeted chimeric-antigen-receptor T-cell Comparing T-cell redirecting therapies, the incidence rate of severe infections was significantly lower M Lesokhin Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Subsequently, primary ovarian cancer cells derived from ascites and ovarian cancer cell lines were used , RNA-seq Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

atypical receptor ACKR3 both respond to CXCL12 but induce different effector responses to regulate cell While CXCR4 couples to G proteins and directly promotes cell migration, ACKR3 is G protein-independent single-molecule FRET Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

The effect of breast cancer cell-conditioned media (BC-CM) on the pro-inflammatory phenotype of VSMCs Tags Breast cancer , Regulator of G protein signaling 5 , Vascular remodeling , Vascular smooth muscle cells Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Results show that the elevated expression of UCA1 enhances cell proliferation, invasive migration, and therapy resistance in high-grade serous ovarian carcinoma cells, whereas silencing UCA1 reverses these UCA1 , lncRNA Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

receptors in the central nervous system and one of the key proteins for signal transduction between cells J Lawrence Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

These might serve as allosteric agonists of PAR1 on endothelial cells and platelets, and thus might contribute Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

emphasizing the structural and evolutionary significance of TACR3 and provided an in-depth analysis of cell Chao Zhang Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

inflammation is characterized by overexpression and heightened activity of type 2 cytokines, mediators and cells FeNO , Fractional exhaled nitric oxide , G-protein-coupled receptor , GPCR , Group 2 innate lymphoid cell , IL-31RA , IL-33R , IL-4Rα , IL-5Rα , ILC , ILC2 , IRF1 , IgE , Immunoglobulin E , Innate lymphoid cell immunoglobulin-like lectin 8 , Signal transducer and activator of transcription , Substance P , T helper type 2 cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

In turn, due to overexpression of GPCRs on the surface of various types of cells, GPCR ligands can endow nanoparticles with active targeting capacity for specific cells via ligand-receptor binding and mediate transduction Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Friday, November 3rd / 12:10 PM Lunch 1 Read More Friday, November 3rd / 1:30 PM Interaction with the cell adhesion molecule NEGR1 affects mGluR5 cell signalling Fabiola Ribeiro Federal University of Minas Gerais Rasmussen Rockefeller University Read More Friday, November 3rd / 4:35 PM Targeting adenosine signaling for immuno-oncology Saturday, November 4th / 7:30 AM Breakfast 2 Read More Saturday, November 4th / 8:15 AM Distinct sub-cellular

, 2023 Abstract "Macrophages release soluble mediators following efferocytic clearance of apoptotic cells macrophage Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

The precise mechanisms by which ACs contribute to cancer cell proliferation and invasion are not well Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

for a randomised controlled trial (RCT), including sham apheresis, and for an RCT combining IA with B-cell post-COVID syndrome Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Among the five somatostatin receptors, SST2 and SST3 are associated with apoptosis and cell cycle arrest Michel Afargan Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

transcriptomic, proteomic, and phosphoproteomic differential expression data of GPR56 knockdown U373-GBM cells Signaling , TG2 Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Planar cell polarity (PCP) proteins contribute to tumour growth and invasion. protein isoforms differentially regulate tissue adhesiveness by influencing the stability/plasticity of cell-cell and cell-matrix contacts. assays in vitro and in vivo, whether CELSR1 protein isoforms differentially influence the stability of cell-cell adhesion and play roles in transmitting extracellular signals to the inside of the cell.

Mathematical models of biochemical reaction networks are an important and emerging tool for the study of cell Edward C Stites Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

human peripheral blood, the neutrophil granulocytes (neutrophils) are the most-abundant white blood cells protein-coupled receptors (GPCRs), are critical for the elimination of pathogens and inflammatory insults, as well transactivation Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call