Here, we demonstrated that the neutrophil-expressed G-protein-coupled receptor (GPCR) Mrgpra1 is a negative As a subset of neutrophils at steady state expressed NPFF, these findings could have broad implications

Following her postdoctoral studies on protein dynamics simulation methods at University of Southern California contributions in developing constrained molecular dynamics simulation methods with emphasis on application to G-protein

Sakmar’s laboratory at Rockefeller University, where she studies the signaling and degradation of G protein-coupled understand the signaling and degradation of GPCRs in disease states to help test the feasibility of using protein-targeted

Here we show that the G protein-coupled receptor (GPCR) to cAMP pathway is responsible for transmitting These studies highlight a crucial G protein signaling pathway for cell communication that is mediated Jing Gao, Huiqing Liu, Yuxin Jin, Yunbo Luo, Kunlun Huang, Zhihong Liang Tags Cell communication , G protein-coupled

Xu et al. identified the mammalian neurokinin 3 receptor (TACR3), a homolog of the G protein-coupled structural and evolutionary significance of TACR3 and provided an in-depth analysis of cell type specific expression of TACR3 in response to renal injury and expressional dynamics during renal carcinoma progression.

dynamics in the mesenchymal transition of glioblastoma Published date November 19, 2023 Abstract "G protein-coupled In our earlier study, we reported that GPR56 is expressed heterogeneously in glioblastoma (GBM) and is Thus, based on transcriptomic, proteomic, and phosphoproteomic differential expression data of GPR56

Emerging GPCR targets for AUD: Insights from preclinical studies Published date July 5, 2024 Abstract "G protein-coupled GPCRs) are the largest group of membrane receptors in the central nervous system and one of the key proteins focus on the past 5 years, on GPCR targets with the potential for reducing behaviours associated with excessive

rigorous mechanistic insights into the structure, dynamics, and function of important classes of membrane proteins and prominent drug targets, including G protein-coupled receptors (GPCRs), transporters, channels, and

With respect to GPCRs, I'm particularly interested in peptide/small protein receptors and the mechanisms With a special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular Slosky’s research is focused on understanding how neuropeptide G protein-coupled receptors (GPCRs) regulate These ligands stimulate receptor β-arrestin recruitment without activating canonical G protein signaling

There was no difference in adrenocorticotropic hormone expression between any of the groups. The transcriptome analysis results showed that the downregulated differentially expressed genes (DEGs -bb1, Oprm1, Zfhx2, Gpr83, and Chrm2) were enriched in pathways related to inhibitory Gi-mediated G protein-coupled Progressive neuroinflammation spreads after injury, and neurotransmission through Gi-mediated G protein-coupled

sterile and infectious inflammation Published date January 1, 2023 Abstract We recently found that the G protein of this pro-resolving receptor in modulating macrophage biology using a novel mouse line where the expression Peritoneal macrophages obtained from naïve MacGpr101KO mice displayed a marked shift in the expression

G-protein-coupled receptors (GPCRs) sense metabolites and can act as key mediators that translate gut Here, we show that GPR31, which is activated by the gut bacterial metabolite pyruvate, is specifically expressed

Inflammatory Diseases Published date April 20, 2023 Abstract " The CC chemokine receptor 6 (CCR6) is a G protein-coupled Th17 cells express the CCR6 receptor and inflammatory cytokines, including IL-17, IL-21 and IL-22, which

human GPRC5D homodimer Published date June 19, 2024 Abstract "GPRC5D is an atypical Class C orphan G protein-coupled Its high expression on the surface of multiple myeloma cells has rendered it an attractive target for

G protein-coupled receptors (GPCRs) mediate a vast variety of critical biological processes and provide How can we best leverage these exciting new techniques in areas such as protein structure prediction,

Fellow, and Director of the Australian Research Council Centre for Cryo-electron Microscopy of Membrane Proteins in the study of GPCRs, biased agonism, and also on allosteric interactions between GPCRs and other proteins

His thesis work led to the development and application of light energy transfer methodology to study protein-protein

Rosie Dawaliby "I’m an expert in early-stage drug discovery, targeting membrane proteins, especially Switzerland, Department of Biochemistry (2005-2009), where I started working on membranes and membrane protein

Molecular Medicine and Neuroscience at the University of Ottawa as a Postdoctoral Fellow to explore novel G protein-coupled Sakmar’s laboratory at The Rockefeller University, where she study’s the signaling and degradation of G protein-coupled understand the signaling and degradation of GPCRs in disease states to help test the feasibility of using protein-targeted

Domain in a Holo-Adhesion GPCR Demet Araç Heterogeneity of Tethered Agonist Signaling in Adhesion G Protein-Coupled Receptors Andrew Dates Discriminating between the extracellular scaffolding and G protein signaling Axel Brunger’s lab at Stanford University to study the structure and function of cell-adhesion proteins As an undergraduate, he studied opioid receptor trafficking and G protein conformational dynamics in Dates on the web Harvard Medical School Discriminating between the extracellular scaffolding and G protein

Here, we demonstrate that CB2, a G-protein-coupled receptor (GPCR) and member of the endocannabinoid system, is expressed on both visceral adipose tissue (VAT)-derived murine and human ILC2s. Our results show that CB2 stimulation of ILC2s protects against insulin-resistance onset, ameliorates

The expression patterns of ACs in numerous cancers are discussed. Chandra Jena, Daniel P Flaherty, Valerie P O'Brien, Val J Watts Tags Adenylyl Cyclase , Cancer , G protein

responses depends on orchestrated migration of B cells within lymphoid organs, which is governed by G protein-coupled Our recent study revealed that a protein complex consisting of copper metabolism MURR1 domain-containing

In 2016 mini-G proteins were developed as a tool for the structure determination of GPCRs in the fully coupled to either mini-Gs or mini-Go, and also by electron cryo-microscopy of receptors coupled to mini G protein

and cancers Published date March 15, 2023 Abstract " C-X-C motif chemokine receptor 2 (CXCR2) is G protein-coupled Hence, we provide an overview containing the discovery history, protein structure, signaling pathways

With a special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular

We analyzed the gene expression profiles of PR-low and control T-47D cells in the absence of hormone Differentially expressed (DE) genes between experimental groups were characterized based on RNA-seq and Results: The overall gene expression pattern was very similar between untreated PR-low and untreated analysis revealed seven significantly enriched biological processes affected by PR and associated with G protein-coupled cancer cell pools , progesterone response , RNA-seq , CRISPR/Cas9 , estrogen receptor alpha , gene expression

nanobody platform within the research group and used this platform to develop nanobodies targeting viral G protein-coupled in multiple projects where he focuses on the generation of nanobodies against "difficult-to-target" proteins