Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back

Strategic Partners Back to Partners List Submit Thanks for submitting! We'll get back to you to set up a meeting.

TRAVELING TIPS Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Register DO's and DONT's for travelers in Mexico Mexico travel advice *Travelers are encouraged to consult their country's embassy advisories as they may differ from the one posted above. The Canadian embassy provides a comprehensive list. Register for the Adhesion GPCR 2024 Learn more about the Adhesion GPCR workshop 2024 Up About the event Learn more about the Adhesion GPCR workshop 2024 and its preliminary program. Up About the venue Discover Cinvestav, the host venue for the upcoming workshop. Up Abstract Submission Submit your research abstracts following our guidelines to present at the conference. Up Logo Contest Enter our logo contest for a chance to have your design represent the upcoming event.

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back

Register for the Adhesion GPCR workshop 2024 Adhesion Workshop for Consortium Members $ 250 250$ Every year +$8 Transaction fee Adhesion GPCR Workshop 2024 + One Year Free Premium Membership Select Adhesion GPCR Workshop 2024 One Year Dr. GPCR Premium Membership *Automatically renews, see confirmation email for details *Cancel anytime *Free membership excludes personnel from US gov. agency Adhesion Workshop for Students $ 200 200$ Every year +$6.30 Transaction fee Adhesion GPCR Workshop 2024 + One Year Free Premium Membership Select Adhesion GPCR Workshop 2024 One Year Dr. GPCR Premium Membership *Automatically renews, see confirmation email for details *Cancel anytime *Free membership excludes personnel from US gov. agency Adhesion Workshop for Industry $ 400 400$ Every year +$12.30 Transaction fee Adhesion GPCR Workshop 2024 + One Year Free Premium Membership Select Adhesion GPCR Workshop 2024 One Year Dr. GPCR Premium Membership *Automatically renews, see confirmation email for details *Cancel anytime *Free membership excludes personnel from US gov. agency Sponsor this event Register now to join the exclusive Adhesion GPCR Workshop group and stay updated with all the latest event news. Join the AGPCR24 group How to register for the Adhesion GPCR workshop 2024? If you're a Dr. GPCR Ecosystem member 01 Register for the event 02 Accept the invitation to the private group If you're not a Dr. GPCR Ecosystem member 01 02 03 Click "Sign up" and make sure you mention "AGPCR24 Workshop" when you fill out the information Wait to be accepted in the Ecosystem Register for the event and accept the invitation to the private group

Register for the AGPCR24 Welcome to the Adhesion GPCR Workshop 2024 , hosted in the vibrant heart of Mexico City at the prestigious venue, CINVESTAV - Centro de Investigación y de Estudios Avanzados del IPN (in English: Center for Research and Advanced Studies of the National Polytechnic Institute). About the venue Cinvestav: Centro de investigación y de Estudios Avanzados del IPN Av. Instituto Politécnico Nacional no 2508 Mexico City, C.P. 07360 ​ Room: Auditorium Arturo Rosenblueth *Have an ID card ready (Passport, Driver's license, etc), as this will be required at the venue entrance Register now to join the exclusive Adhesion GPCR Workshop group and stay updated with all the latest event news. Join the AGPCR24 group Preliminary Program Layout Date Time Title October 23, 2024 October 24, 2024 October 25, 2024 *Flash Presentations: 10 min *Talks 20 min (15 min+ 5 min questions Register for the AGPCR24 [ Registration extended until September 15th ] Everything you need to know about the event Listen to Dr. Antony Boucard and Dr. Yamina Berchiche at the Dr.GPCR Newsletter Learn more about the Adhesion GPCR workshop 2024 Up Abstract Submission Submit your research abstracts following our guidelines to present at the conference. Up About the venue Discover Cinvestav, the host venue for the upcoming workshop. Up Traveling Tips Find essential tips about Mexico City, including transportation options and local insights. Up Logo Contest Enter our logo contest for a chance to have your design represent the upcoming event.

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back

GPCR Retreat Organizers

Become Dr. GPCR Strategic Partner Request Your Quote How Organizations can benefit from Dr. GPCR Ecosystem? Request Your Quote Learn more Sign Up

About Dr. GPCR Ecosystem We bring the GPCR community to fuel GPCR drug discovery one receptor at a time. The goal is to increase understanding of GPCR function and discover better drugs together. About Us: About Us Founded in 2020, we decided to bring together the GPCR community and break down any barriers separating our field. We aspire to provide opportunities to connect, grow, and thrive together as a dynamic group. The goal is to better understand and exploit the druggability of GPCRs, together. To join the community you must be related to the GPCR field. Once in the Dr. GPCR Ecosystem, you’ll get to: Interact with the members and partners to help you find: Answers to any GPCR related questions Collaborators Consultants Partners Mentors Your next position Free access to the Dr. GPCR programs including the: Summit Virtual Cafe Listening to podcast episodes before these are released to the general public Newsletter Job board Looking to partner with us? Join us today and you’ll get to: Interact directly with your target audience Access to all member perks for your entire team Add your product and service listings Help shape the GPCR field ​ About Dr. GPCR Podcast Meet the Team Committed to Our Cause We’re very proud of the diversity of our team, and their abilities to contribute their own unique experience and skills to our success. Find out more about some of our leaders and volunteers below. Contact Us Dr. Yamina Berchiche Founder & Director Get in Touch Attila Foris Brainstorm Officer Get in Touch Andreína Martín Project & Social Media Manager Get in Touch Ivanna Rey Executive Assistant Get in Touch Dr. Inês Pinheiro Business Development & Scientific Associate Get in Touch Dr. Monserrat Avila Zozaya Business Development & Scientific Associate Get in Touch Ya-Tzu Li Business Development & Scientific Associate Get in Touch Cam Sinh Lu Business Development & Scientific Associate Get in Touch Dr. John Teye Azietaku Business Development & Scientific Associate Get in Touch Balint Bajnoczki Video & Podcast Editor Get in Touch Mark Schmeizl Chief Matchmaker Get in Touch About Us: Team

Premium Monthly $24.99 $ 24.99 Every month ​ Immerse yourself into the GPCR World Valid for 12 months + 5 day free trial Select Go to GPCR Retreat Page

Meet Dr. GPCR Summit Partners - Click to Explore - Dr. GPCR Summit 2021 Welcome to the official page of the Dr. GPCR Virtual Summit 2021! << Live talk schedule >> << Pre-recorded talk list >> The program is complete! Don't miss a chance to listen to 25+ scientific talks, which will only be available for those who registered during the Summit. Get your All-Access ticket before they're gone by visiting Eventbrite today! Got your All-Access ticket already? Special shout out to our partners! Check your inbox this week, you'll be able to invite a friend or colleague to join the Summit for Free! Proceeds from the ticket sales will be used to provide the best three trainee talks with fantastic prizes, including a personalized autographed copy of Dr. Lefkowitz's biography. Present a pre-recorded talk and get free access to the entire Summit! Hurry, the deadline to submit your talk is Friday, September 10th, 2021, at midnight EST. If you're facing financial difficulties or are a trainee who would like to attend but can't submit a pre-recorded talk, reaches out to us now! The live talks will be held on Zoom, and everyone who registered will be able to ask their questions to the speakers all week on Microsoft Teams! You'll also be able to meet our partners on Microsoft Teams. Make sure you have a profile picture set for both Zoom and Microsoft Teams! Everyone is welcome to present their work (students, postdocs, PI's, biotech, pharma companies)! There are no posters! All pre-recorded talks will be available during the summit for free with registration. All live talks will have a $5 attendance fee/ talk You can get full access to all the talks for $100 For Speakers Step 1: Let us know that you'd like to present your work by filling out this short form here Step 2: Prepare your video abstract and your presentation (pre-recorded or live)* Step 3: Click here to send us your pre-recorded presentation or click here*** to submit the information to your live presentation before August 5th, 2021. ***All live talks are now scheduled Please provide us with your pre-recorded presentation by September 10th, 2021 *Note: Scroll down to find resources to help you prepare your video presentation, and don't hesitate to get in touch if you need help. Contact us at Hello@DrGPCR.com Some housekeeping items first We strongly suggest you carefully consider what type of information you share in your presentation. We will do our best to keep the Summit a closed event, but Dr.GPCR is not responsible for any loss of intellectual property. How will I access the talks during the Summit? ​ You will receive an email from Eventbrite containing the relevant information before the summit. Be sure to register. How can I sponsor the 2021 Summit? Please visit our Sponsor Page to learn more about sponsorship opportunities to sponsor the Summit and the DrGPCR Ecosystem. For more information, please email us at Hello@DrGPCR.com In what form can I submit my abstract? Abstract submission can be in the form of classical text abstract or in the form of a short (max. 3 minutes) video. This is an excellent opportunity to be as creative as you want to be. We recommend writing a 200-300 word abstract, giving you enough information to provide a great video abstract in under 3 minutes. How will I present my talk? You can pre-record your talk. We recommend submitting pre-recorded talks. What does this mean? ​ You send us the video of your full-length talk, and we will take care of the rest. Alternatively, you can provide us with the embed code to make your presentation available during the Summit. ​ Pros: You can polish your recording to your satisfaction. Anyone can watch it from anywhere, even multiple times. Imagine binge-watching your favorite talk over and over whenever you want to during the Summit. Cons: It may take more time to record an excellent presentation, but nothing is impossible! Click here to submit your pre-recorded presentation. Can I present a live talk or event? How? In case you'd like to present a talk live, we'll help with it. Pros: It may take less time to prepare for the presentation Cons: You may make mistakes since it's a live event, and if you decide to keep your talk live only, participants can watch it only once. *Tip Become a DR. GPCR Member by creating your own personalized page. Read more about becoming a member here . If you need help preparing your pre-recorded video and video abstract check out these resources: How to record your talk in PowerPoint 365 How to record your talk using a previous PowerPoint version How to record your talk using Keynote on a Mac Do you have any questions? ​ Email us at Hello@DrGPCR.com << Live talk schedule >> << Pre-recorded talk list >> Meet Dr. GPCR Summit Partners - Click to Explore - Tags Dr. GPCR Summit Dr. GPCR Summit 2021 Dr. GPCR Summit 2021 Pre-Recorded Talks Dr. GPCR Summit 2021 Live Talks

Dr. GPCR University The Dr. GPCR Ecosystem is the ultimate learning platform for expanding your knowledge, making connections, and staying informed in the world of GPCR. Get started - 5 days free trial - Sign up for free! Strategic Partnerships Are you working for a GPCR organization? We want to partner with you! Contact us and find out how we can collaborate together. Contact us Heading 1 Register What would you like to learn today? Dr. GPCR Courses Details Dr. GPCR Symposia Details Dr. GPCR Summit Details Dr. GPCR Virtual Cafe Details Our Vision Closing the gap ( between academia and industry ) and accelerating drug discovery. UniversityPrice Premium Monthly $ 24.99 24.99$ Every month Immerse yourself into the GPCR World Valid for 12 months + 5 day free trial Start Free Trial Live and Recorded Courses Exclusive access to early bird special Access to previous events recordings Premium Yearly $ 249.99 249.99$ Every year Immerse yourself into the GPCR World 5 day free trial Start Free Trial Live and Recorded Courses Exclusive access to early bird special Access to previous events recordings Become Dr. GPCR Strategic Partner

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back

Dr. GPCR Symposia Virtual - FREE - event series of 1-day. *Talks will be available for later viewing for the Ecosystem’s premium members. Become a Premium member Our Goal 1. Increase the number of events during the calendar year to meet more frequently. 2. Provide more topic-specific events to the GPCR community All Symposia Events are: 1. Virtual 2. Free for all members 3. Poster presentation 4. Networking GPCRs in Immunology and Oncology November 17, 2023 Details GPCRs as Therapeutic Modalities September 22, 2023 Details Structural and Molecular Insights into GPCR Activation July 21, 2023 Details GPCR Activation and Signaling May 19, 2023 Details Recent Advances in Understanding Challenging GPCRs March 24, 2023 Details SymposiaPrice Premium Monthly $ 24.99 24.99$ Every month Immerse yourself into the GPCR World Valid for 12 months + 5 day free trial Start Free Trial Live and Recorded Courses Exclusive access to early bird special Access to previous events recordings Premium Yearly $ 249.99 249.99$ Every year Immerse yourself into the GPCR World 5 day free trial Start Free Trial Live and Recorded Courses Exclusive access to early bird special Access to previous events recordings Become Dr. GPCR Strategic Partner

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Biased agonism at the GLP-1 receptor: from structure to animal models of disease Date & Time Friday, November 3rd / 11:05 AM Abstract Coming Soon About Patrick Sexton " Patrick Sexton is a NHMRC Senior Principal Research Fellow and Director, ARC Centre for Cryo-electron Microscopy of Membrane Proteins ( www.ccemmp.org ). He is a leader in the study of GPCRs. Recently, his team has applied cryo-EM to elucidation of the structure and dynamics of GPCRs. Prof. Sexton has published over 335 peer reviewed journal articles and has been cited >29,000 times (Google Scholar). He is a 2022 Clarivate Analytics Highly Cited Researcher in two disciplines: Pharmacology & Toxicology; Biology & Biochemistry, a corresponding member of NC-IUPHAR, a member of the Faculty of 1000 and an elected Fellow of the British Pharmacological Society (BPS). Prof. Sexton’s awards include the ASCEPT Lecturer award, Endocrine Society (Australia) Senior Plenary award, Rand Medal (ASCEPT), Paxinos-Watson Award (Australian Neuroscience Society), Vane Medal (BPS), Gordon Hammes Lectureship Award (American Chemical Society) and the GSK Research Excellence award. Prof. Sexton is also a co-founder of Septerna Inc. " Patrick Sexton on the web CCeMMP Monash University Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

< GPCR News < GPCRs in Oncology and Immunology CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions Published date September 20, 2023 Abstract "Prenylation is an irreversible post-translational modification that supports membrane interactions of proteins involved in various cellular processes, including migration, proliferation, and survival. Dysregulation of prenylation contributes to multiple disorders, including cancers and vascular and neurodegenerative diseases. Prenyltransferases tether isoprenoid lipids to proteins via a thioether linkage during prenylation. Pharmacological inhibition of the lipid synthesis pathway by statins is a therapeutic approach to control hyperlipidemia. Building on our previous finding that statins inhibit membrane association of G protein γ (Gγ) in a subtype-dependent manner, we investigated the molecular reasoning for this differential inhibition. We examined the prenylation of carboxy-terminus (Ct) mutated Gγ in cells exposed to Fluvastatin and prenyl transferase inhibitors and monitored the subcellular localization of fluorescently tagged Gγ subunits and their mutants using live-cell confocal imaging. Reversible optogenetic unmasking-masking of Ct residues was used to probe their contribution to prenylation and membrane interactions of the prenylated proteins. Our findings suggest that specific Ct residues regulate membrane interactions of the Gγ polypeptide, statin sensitivity, and extent of prenylation. Our results also show a few hydrophobic and charged residues at the Ct are crucial determinants of a protein's prenylation ability, especially under suboptimal conditions. Given the cell and tissue-specific expression of different Gγ subtypes, our findings indicate a plausible mechanism allowing for statins to differentially perturb heterotrimeric G protein signaling in cells depending on their Gγ-subtype composition. Our results may also provide molecular reasoning for repurposing statins as Ras oncogene inhibitors and the failure of using prenyltransferase inhibitors in cancer treatment." Authors Mithila Tennakoon , Waruna Thotamune , John L Payton , Ajith Karunarathne Tags HMG-CoA reductase , cholesterol , mevalonate pathway , optogenetics , prenylation , prenyltransferases , statin Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr. GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. GPCR Monthly Newsletter today! Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >