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infectious inflammation Published date January 1, 2023 Abstract We recently found that the G protein coupled receptor Herein, we investigated the endogenous role of this pro-resolving receptor in modulating macrophage biology in the expression of phenotypic and activation markers, including the Interleukin (IL)-10 and IL-23 receptors

Lysophosphatidic acid (LPA) is a lipid that activates G protein-coupled receptors (GPCRs), enhancing In these cells, the mitogenic activity of LPA is mediated by LPA Receptor 1 (LPAR1), a GPCR. Specifically, CCNs secreted into the extracellular space can facilitate the activation of additional receptors

During his graduate studies, Emile is interested in characterizing novel G protein-coupled receptors Title: Synapse-Associated Protein 102 and Post-Synaptic Density 95 Differentially Shape Dopamine D1 Receptor Signaling About Bassam Albraidy "My thesis focus on studying the interaction of dopamine D1 receptors

and worked closely with Dr Birgitte Holst studying structural and mechanistic properties of ghrelin receptor associated with obesity and other metabolic diseases, including GPR10, Melanocortin 4, Serotonin 2C and TRH receptors cell-based in vitro technologies to study mechanistic properties of GPCRs and understanding the dynamics of receptor Jacek shared his fascination with the growth hormone secretion receptor and the melanocortin 4 receptor Yamina, in turn, talked about her work on melanocortin receptors and an upcoming collaboration with a

Hannes Schihada Following studies in Pharmacy in Regensburg, Germany, I joined the receptor pharmacology I spent 2 1/2 years in his lab and developed novel conformational sensors for these intriguing receptors

pharmacology, and pharmacoepidemiology with innovative computational methods to gain novel insights into receptor identify human signaling systems and thereby discovered endogenous peptides activating several orphan receptors

focuses on the mechanisms underlying biased signaling at GPCRs, specifically, the role of differential receptor He primarily studies the chemokine receptor CXCR3 as it has three naturally occurring ligands and thus

Finally, we identified that G protein-coupled receptor (GPCR)-phospholipase C (PLC)-inositol trisphosphate receptor (IP3R)-store-operated Ca2+ (SOC) signaling was crucial for enhancive cytosolic Ca2+ and PEDV G protein-coupled receptor (GPCR)-phospholipase C (PLC)-inositol trisphosphate receptor (IP3R)-SOC signaling

which we've curated the major advances in understanding GPCR biology and moving closer to targeting receptors

peptide agonist mechanism that differed from the common example known at the time, protease activated receptors Adhesion GPCRs pre-cleave themselves and the two resultant fragments of the receptor remain together adhesion GPCRs in complex physiological contexts…one being our discovery that GPR56 is the platelet receptor

Ph.D. from Department of Pharmacology, University of Washington (1992, mentor Charley Chavkin , sigma receptors Focus on study of drugs and toxins on GPCR (opioid, cannabinoid receptor) and ion channel (K, Ca, TRP

Mark von Zastrow where she identified novel core cellular machinery critical for G protein-coupled receptor cell biological mechanisms regulating GPCR activity, including spatial control of GPCR signaling and receptor

developing a powerful new computational tool for identifying ‘surrogate’ ligands (borrowed from other receptors this expertise to establish a research program that takes orphan GPCRs from ‘locked’, inaccessible receptors

GPCR Retreat Program < Back to schedule Structure-based discovery of functionally selective 5-HT1A receptor

< GPCR News < GPCRs in Oncology and Immunology Protease-Activated Receptor-1 IgG Autoantibodies in Patients

< GPCR News < GPCRs in Oncology and Immunology Autocrine proteinase-activated receptor signaling in PC3

) in largemouth bass (Micropterus salmoides) Published date October 24, 2024 Abstract "CC chemokine receptors (CCRs), the numbers of the G protein-coupled receptor (GPCR) superfamily, had crucial roles in treating Our results provided basis for elucidating the functions of chemokine-receptor complex in largemouth

interacting with cell surface-expressed CXCL16 and plays a key role in G-protein selectivity during receptor These substitutions at the DRF motif affect the receptor-Gi/o protein interaction. Authors Buddhabhushan Girish Salve, Sandhya Sharma, Nagarjun Vijay Tags ITGAE , Chemokine receptors ,

perception, transmission, and feedback are all rely on a signal network that constituted by membrane receptors Here we show that the G protein-coupled receptor (GPCR) to cAMP pathway is responsible for transmitting Liu, Yuxin Jin, Yunbo Luo, Kunlun Huang, Zhihong Liang Tags Cell communication , G protein-coupled receptor

fibrosis in a murine model with fibrotic bone Published date May 1, 2024 Abstract "G protein-coupled receptors mice, in which Gs-GPCR signaling was hyper-activated in osteoblastic cell lineages using an engineered receptor fibrotic bone disease , fibrous dysplasia (FD) , osteoblasts , trabecular bone , G-protein coupled receptor

GPCRs in personalized cancer therapy Published date September 12, 2024 Abstract "G protein-coupled receptors (GPCRs) are vital cell surface receptors that govern a myriad of physiological functions.

Immunology Prediction of survival and immunotherapy response by the combined classifier of G protein-coupled receptors Zhang , Yu Zhu , Jia Feng , Feng Qin , Yanwen Yang , Chuanyuan Wei , Jianying Gu Tags G protein-coupled receptors

< GPCR News < GPCRs in Oncology and Immunology Lactate receptor GPR81 drives breast cancer growth and properties and Notch ligand DLL4 Published date November 22, 2023 Abstract " Background: The lactate receptor

Immunology Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Moreover, the GBP2-induced response was silenced by pre-treatment with dsRNA targeting the GBP receptor

Antibody-drug conjugates targeting CD97 in glioblastoma Dimitris Placantonakis Adhesion G protein-coupled receptor localized in the developing and adult synapses and interact with synaptic scaffold proteins and glutamate receptors Several adhesion G protein-coupled receptors (aGPCRs) have recently been shown to play critical roles Dimitris Placantonakis on the web Placantonakis Lab Google Scholar LinkedIn Adhesion G protein-coupled receptor endeavoring to build a productive, independent scientific research career in adhesion G protein-coupled receptor

obtained his Ph.D. from the University of Manitoba – Canada, where he was introduced to G protein-coupled receptors His doctoral research focused on the structural and functional characterization of bitter taste receptors

G protein-coupled receptors (GPCRs) mediate a vast variety of critical biological processes and provide for quantitative, and multi‐scale integration of these amounts of data to gain novel insights into receptor

Blanco Redondo Abstract "The Drosophila genome contains five loci encoding adhesion G-protein coupled receptors remoulade (remo) gene is a homologue of the vertebrate aGPCR ADGRA family, sharing the same overall receptor We found that the receptor is cleaved despite the lack of a consensus GPS sequence. Langenhan where I am studying and characterizing newly generated adhesion GPCR receptors in Drosophila