Search Results
215 items found for "Bcl-2"
- Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling Published date June 21 , 2024 Abstract "Colorectal cancer (CRC) remains a major global cause of cancer-related mortality, lacking
- Ep 142 with Dr Claudia Stäubert
Since 2014, I have led a research group at the Rudolf Schönheimer Institute of Biochemistry in Leipzig
- G protein-coupled estrogen receptor (GPER)/GPR30 forms a complex with the β1-adrenergic receptor, a membrane-associated guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells
protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells Published date January 10, 2024
- Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
GPCR signaling reveals unexpected differences in downstream pathway activation Published date July 16, 2024
- Deciphering the genetic landscape of lumpy skin disease: Unraveling variable virulence through comprehensive genome sequence analysis in India
Unraveling variable virulence through comprehensive genome sequence analysis in India Published date May 23 , 2024 Abstract "Lumpy Skin Disease (LSD), a poxvirus disease affecting cattle, emerged in India in 2019 and intensified in 2022, resulting in significant economic losses for dairy farmers. A comprehensive genetic study conducted, analyzing samples from 2019 to 2022 revealed circulation of outbreaks, absent in 2019 samples.
- The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
signaling axis promotes T cell dysfunction and cancer immunotherapy failure Published date June 12, 2023 druggable immune checkpoints that might be targeted to enhance the response to ICB immunotherapies. © 2023
- Ep 65 with Dr. Sudarshan Rajagopal
He was awarded his Ph.D. in 2004 and his MD in 2006.
- Ep 70 with Dr. Stephen Ferguson
He has held four Canada Research Chairs since 2001 and was previously a Heart and Stroke Foundation of Canada MacDonald Scholar (1998-2003) and Heart and Stroke Foundation of Ontario Career Investigator (2003-2016). Jubilee Medal, in 2012. He has also received both Junior (2001) and Senior (2005) investigator awards from the Pharmacological
- Ep 145 with Dr John Janetzko
John Janetzko "I received my Honors BSc in Chemistry from the University of Toronto in 2011, with a focus Brian Kobilka at Stanford University at the end of 2017 for postdoctoral work. In July 2024 I will join the University of Colorado, Anschutz Medical Campus, as an Assistant Professor
- Ep 155 with Endocrine Metabolic GPCR Organizers
GPCR Podcast << Back to podcast list Re-cap of Endocrine Metabolic GPCR 2024 with the Organizers About Aylin Hanyaloglu has been a Principal Investigator at Imperial College London since 2007. Edinburgh, a move to Perth, Australia resulted in her Ph.D. in Molecular Endocrinology being awarded in 2002 She obtained her PhD in 2012 from the University of Oxford, where her research focused on the cellular Caroline moved to the University of Birmingham in 2018 to establish her research group investigating
- Ep 151 with Dr GPCR Board
Trejo joined the faculty in the Department of Pharmacology at the University of North Carolina in 2000 rose through the ranks to tenured professor in 2012. In 2014, she was appointed Vice-Chair of the Department of Pharmacology. The long-term goal of Dr. From 2002 to 2006, they were a Senior Application Scientist at Accelrys, where they were the technical Finally, since 2006, they have been the Chief Executive Officer at Montana Molecular, LLC.
- Ep 148 with Dr Arthur Christopoulos
Since 2014, Clarivate Analytics have annually named him a Highly Cited Researcher in ‘Pharmacology & Toxicology’, and in 2021 also named him a Highly Cited Researcher in the additional category of ‘Biology In 2017, he was elected a Fellow of the Australian Academy of Health and Medical Sciences, in 2018 as a Fellow of the British Pharmacological Society, and in 2021 he was elected a Fellow of the Australian In 2023, he was elected a Fellow of the Pharmaceutical Society of Australia. " Dr.
- Ep 154 with Dr Badr Sokrat
At the end of 2023, I joined the research group of Dr.
- Biased agonism at the GLP-1 receptor: from structure to animal models of disease
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to Sexton has published over 335 peer reviewed journal articles and has been cited >29,000 times (Google He is a 2022 Clarivate Analytics Highly Cited Researcher in two disciplines: Pharmacology & Toxicology Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd
- CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions
residues influence G protein gamma (Gγ) prenylation under suboptimal conditions Published date September 20 , 2023 Abstract "Prenylation is an irreversible post-translational modification that supports membrane
- CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases
Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases Published date April 20 , 2023 Abstract " The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved Th17 cells express the CCR6 receptor and inflammatory cytokines, including IL-17, IL-21 and IL-22, which
- Regulation and role of mitochondria delta opioid receptors
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to He has 20+ years of experience in in vitro and in vivo GPCR pharmacology and has published seminal papers Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd
- Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis
tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis Published date May 21 , 2024 Abstract "Inflammatory bowel disease (IBD) is characterized by dysbiosis of the gut microbiota Pan Tags Enterococcus , IBD , ISCs , colitis , inflammatory bowel disease , tyramine , yohimbine , α(2A
- Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis
Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis Published date January 1, 2023
- Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant
Immunology Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant Published date November 24 , 2023 Abstract "Microbial infection is characterized by release of multiple proinflammatory chemokines
- Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone
decreases trabecular bone but not fibrosis in a murine model with fibrotic bone Published date May 1, 2024 We previously showed that ColI(2.3)+/Rs1+ mice, in which Gs-GPCR signaling was hyper-activated in osteoblastic Single-cell RNA sequencing on long-bone stromal cells of 9-wk-old male ColI(2.3)+/Rs1+ mice and littermate controls showed that fibroblastic stromal cells in ColI(2.3)+/Rs1+ mice were expanded. blocks Wnt signaling broadly, induced partial resorption of the trabecular bone in the femurs of ColI(2.3
- S1P Signaling Genes as Prominent Drivers of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia
Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia Published date July 1, 2024
- The power of many: Multilevel targeting of representative chemokine and metabolite GPCRs in personalized cancer therapy
representative chemokine and metabolite GPCRs in personalized cancer therapy Published date September 12, 2024
- Distinct sub-cellular signal propagation as a component of functional selectivity
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to Since 2001, he holds the Canada Research Chair in Signal Transduction and Molecular Pharmacology. ), the Julie Axelrod award from the American Society of Pharmacology and Exerimental Therapeutics (2017 ), the Wilder Penfield award from the Quebec Government (2017), the innovation award of ADRIQ (2019) and the 2021 Killam prize form the Canada Council for the Arts."
- G Proteins and GPCRs in Cancer: Novel Precision Targeted and Immunotherapies
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to He served as Branch Chief at NIDCR, NIH, since 1998 until his recruitment to UCSD in 2015. Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd
- Trainee Symposium II
In November 2021, I joined Dr. -2023 and 2023-2024) from the bone and joint institute, Western University and the New Student Poster Award (2022). and 2023." Michel Bouvier, at the University of Montreal from 2015 to 2019.
- Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors
GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors Published date November 1, 2022
- Ep 143 with Dr Davide Calebiro
Between 2009 and 2017, he was a Group Leader at the Institute of Pharmacology and Toxicology and Rudolf