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272 items found for "Cell proliferation"
- RGS7-ATF3-Tip60 Complex Promotes Hepatic Steatosis and Fibrosis by Directly Inducing TNFα
non-alcoholic fatty liver disease (NAFLD) have yet to be fully delineated and only a single drug, peroxisome proliferator-activated
- Pharmacophore-guided Virtual Screening to Identify New β 3 -adrenergic Receptor Agonists
Out of 35 tested compounds, 4 compounds were active in CHO-K1 cells expressing the human β3 -AR, and 8 compounds were active in CHO-K1 cells expressing the mouse β3 -AR."
- Gαs and Gαq/11 protein coupling bias of two AVPR2 mutants (R68W and V162A) that cause nephrogenic di
protein coupled receptor (GPCR) and mainly couples with Gαs protein leading to cAMP accumulation in the cell showed the ability to couple with Gαq/11 protein and make Ca2+ mobilization at different levels in the cell
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Genomic Activity of an EP4-Receptor and β2-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Cells Mechanistic insights from the atomic-level quaternary structure of short-lived GPCR oligomers in live cells November 5 - 7, 2024 | 16th Annual PEGS Europe September 18, 2024 | FREE Webinar - The value of GPCR cell-based
- A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr
effectors recruited by GPCR-bound arrestins are Src family kinases, which regulate cellular growth and proliferation We report that arrestin-3 modulates Fgr activity with a hallmark bell-shaped concentration-dependence
- GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the...
the synovium "The rheumatoid arthritis (RA) inflammatory process occurs in the joints where immune cells evaluated the expression of GPR15 and GPR15L in blood and synovial tissue samples from RA patients, as well synovial fluid and peripheral blood were analyzed for CD45+CD3+CD4+GPR15+ and CD45+CD3+CD8+GPR15+ T cell
- APEX2/AUR Biosensor: A Powerful Tool for Protein Interaction and Trafficking
Therefore, it’s a great molecular tool for proximity labeling approaches in living cells. APEX2 biosensor utilizes a fluorogenic substrate called Amplex UltraRed (AUR).
- Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits
G-protein transducin, Gt, is a key signal transducer and amplifier in retinal rod and cone photoreceptor cells Immunohistochemistry and Western blotting demonstrated the robust expression of each transgenic Gγ in rod cells
- Unlocking the Future of Medicine: Advancements in GPCR Research
underlying atypical chemokine receptor 3 activation RhoA-mediated G12-G13 signaling maintains muscle stem cell quiescence and prevents stem cell loss Activation of Polycystin-1 Signaling by Binding of Stalk-derived November 5 - 7, 2024 | 16th Annual PEGS Europe September 18, 2024 | FREE Webinar - The value of GPCR cell-based
- Diversity and specificity in location-based signaling outputs of neuronal GPCRs
of the G protein-coupled receptor (GPCR) family respond to neurotransmitters in the brain have been well GPCRs, and how these could interact to generate specific spatiotemporal patterns of GPCR signaling in cells
- 📰 GPCR Weekly News, September 25 to October 1, 2023
in Oncology and Immunology LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration Respiratory infections predominate after day 100 following B-cell maturation antigen-directed CAR T-cell therapy SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal Phase 1b Clinical Study of Oral GLP-1 Receptor Agonist GSBR-1290 and Provides Program Update Septerna sells
- Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled ..
Several members of MRGPRs are also expressed in mast cells, macrophages, and in cardiovascular tissue By stimulating human MRGPRD-expressing HeLa cells with the agonist β-alanine, we observed a release of as an assay for β-alanine-mediated activation of MRGPRD is substantially increased by culturing the cells
- Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in ...
In vitro, we used IFNα to stimulate human salivary gland epithelial cells (HSGECs), and the results showed that IFNα activated GRP78-ATF6-CHOP apoptosis signaling, decreased cell viability, and induced apoptosis In addition, β-arrestin2 depletion downregulated GRP78-ATF6-CHOP apoptosis signaling to alleviate cell
- 📰 GPCR Weekly News, February 13 to 19, 2023
GPCR Activation and Signaling Statins inhibit protein kinase D (PKD) activation in intestinal cells and The spatial distribution of GPCR and Gβγ activity across a cell dictates PIP3 dynamics. Artificial Intelligence for Drug Discovery Call for GPCR Papers GPCRs: Signal Transduction.
- 📰 GPCR Weekly News, April 3 to 9, 2023
Methods & Updates in GPCR Research The Road to Quantitative Lipid Biochemistry in Living Cells. FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Jobs Convergent Research - Senior Scientist, Cell-Based
- A cryptic mode of GPCR regulation revealed
In a recent issue of Molecular Cell, Fonseca et al. identified a previously overlooked desensitization
- 📰 GPCR Weekly News, May 8 to 14, 2023
Industry News InterAx Biotech to Apply its Leading AI and Cell Signalling Technology to Support Target FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion Scientist - Antibody Engineering Scientist—Immuno-Oncology Convergent Research - Senior Scientist, Cell-Based
- The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins α9β1 and α4β1
and purpose: Vascular tone is regulated by the relative contractile state of vascular smooth muscle cells
- 📰 GPCR Weekly News, November 13 to 19, 2023
Indicators Design of an effective small expression tag to enhance GPCR production in E. coli-based cell-free and whole cell expression systems A high-throughput structural dynamics approach for identification 2 Study Completes Recruitment of Patients Sanyou Bio's Evolution of Bioprocess Enhancement for CHO Cell
- 📰 GPCR Weekly News, September 4 to 10, 2023
Immunology [1,2,4]Triazolo[1,5-c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer Cell Stephen Dowd As Chief Business Officer Septerna Announces Novel GPCR-targeted Program Acquired by Vertex Call Jobs NEW Senior Research Associate, In Vitro Pharmacology - Crinetics Pharmaceuticals NEW Postdoc In Cell
- 📰 GPCR Weekly News, August 28 to September 3, 2023
GPCR Activation and Signaling Cell death signaling in Anopheles gambiae initiated by Bacillus thuringiensis again: the lysophosphatidic acid-CCN axis in signal transduction NPFF stimulates human ovarian cancer cell Global Healthcare Conference CEO Raymond Stevens to Speak at STAT Future Summit on Obesity Therapeutics Call
- Dynamic GPCR activation revealed through time-resolved Cryo-EM
Human cells express over 800 G-protein-coupled receptors (GPCRs) to facilitate communication with the Capturing the dynamics of GPCR activation has always been a challenge because G protein activation in cells
- 📰 GPCR Weekly News, July 31 to August 6, 2023
Sukhtankar and Pina M Cardarelli's research: Burixafor Hydrobromide (GPC-100) effects on hematopoietic cells -100), a Novel C-X-C Chemokine Receptor 4 Antagonist and Mobilizer of Hematopoietic Stem/Progenitor Cells Research Collaboration Addex Therapeutics To Release Half-Year 2023 Financial Results And Host Conference Call
- The mouse cytomegalovirus G protein-coupled receptor homolog, M33, coordinates key features of ...
The mouse cytomegalovirus (MCMV) GPCR, M33, facilitates dendritic cell (DC)-dependent viremia, the extravasation IMPORTANCE G protein-coupled receptors (GPCRs) act as cell surface molecular "switches" which regulate The mouse CMV (MCMV) GPCR homolog, designated M33, is important for cell-associated virus spread and
- 📰 GPCR Weekly News, July 3 to 9, 2023
GPCRs in Cardiology, Endocrinology, and Taste SOCS3 inhibits the mesenchymal stromal cell secretory factor Updates in GPCR Research Profiling of basal and ligand-dependent GPCR activities by means of a polyvalent cell-based
- 📰 GPCR Weekly News, December 18 to 31, 2023
human neutrophil expressed formyl peptide receptors GPCRs in Cardiology, Endocrinology, and Taste Beta cell 5 and 6 axis prevents diabetic cardiomyopathy in mice GPCRs in Neuroscience Coexistence within one cell revealed by structural pharmacology Industry News The Adrenaline Puzzle Solved: Scientists Untangle Key Cell
- Endocannabinoid System in the Neuroendocrine Response to Lipopolysaccharide-induced Immune Challenge
produced “on demand” to finely regulate the synthesis and secretion of hormones and neurotransmitters, as well It is well known that immune challenges, such as exposure to lipopolysaccharide, the main component of the Gram-negative bacteria cell wall, disrupt not only the hypothalamic–pituitary–adrenal axis but also
- 📰 GPCR Weekly News, October 30 to November 4, 2023
Regulation of Cardiomyocyte Rac1 Signaling Activity and Minor Effects on Cardiac Hypertrophy Single cell Immunology Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer Cells Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways Spliceosome mutations are associated