By combining experimental data with theory on leukocyte chemotaxis guided by the G protein-coupled receptor

fibroblast heterogeneity in fibroblast-associated diseases Published date August 1, 2023 Abstract "G protein-coupled receptors (GPCRs) are the largest and most diverse class of signaling receptors.

identifying novel signal transduction mechanisms of GPCRs, such as the formation of complexes between G proteins and beta-arrestins.

Here, we demonstrate that CB2, a G-protein-coupled receptor (GPCR) and member of the endocannabinoid Our results show that CB2 stimulation of ILC2s protects against insulin-resistance onset, ameliorates

Bikash Chandra Jena, Daniel P Flaherty, Valerie P O'Brien, Val J Watts Tags Adenylyl Cyclase , Cancer , G protein , GPCR , Hallmarks of Cancer , cAMP signaling .

We investigated the prognostic values of the guanine nucleotide-binding protein G(i) alpha subunit (GNAI Sanskriti Dey , Sachin Kumar , Adrian Wangsawijaya Santoso , Bianca Tobias William , Chih-Yang Wang Tags G-protein-coupled

With a special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular

+ T cells and boosts HIV-1 R5 replication Published date May 21, 2024 Abstract " Objective: CCR5, a G protein-coupled receptor (GPCR), is used by most HIV strains as a coreceptor. HIV-1 entry was quantified with virions harboring β-lactamase fused to the viral protein vpr, early and

date July 22, 2024 Abstract "Fibrosis is characterized by excessive deposition of extracellular matrix proteins Although G protein-coupled receptors (GPCRs) are among the targets of current antifibrotic drugs, no

treatment through network pharmacology and molecular docking Published date October 28, 2024 Abstract "G Protein-Coupled Receptors (GPCRs) are integral membrane proteins that have gained considerable attention Subsequently, we established a protein-protein interaction (PPI) network by mapping the shared targets

cancer-rewired GPCR signaling axes Published date May 8, 2024 Abstract "We explored the dysregulation of G-protein-coupled

feed-forward activation of the SK1-S1P1 signaling axis Published date August 15, 2023 Abstract "The G protein-coupled receptor (GPCR) US28 encoded by the human cytomegalovirus (HCMV) is associated with accelerated

its dynamics in the mesenchymal transition of glioblastoma Published date November 19, 2023 Abstract "G protein-coupled receptor 56 (GPR56/ADGRG1) is a multifunctional adhesion GPCR involved in diverse biological Thus, based on transcriptomic, proteomic, and phosphoproteomic differential expression data of GPR56

G-protein-coupled receptor class C group 5 member D (GPRC5D), an orphan GPCR predominantly expressed

date January 2, 2023 Abstract “ Vasoactive intestinal peptide (VIP) receptor 2 (VIPR2) is a class B G protein-coupled receptor with the neuropeptide VIP as a ligand. phosphorylated extracellular signal-regulated kinase (ERK), which involves a VIPR2 signaling pathway through Gs protein phosphorylation of vasodilator-stimulated phosphoprotein (Ser157) and cAMP response element binding protein Moreover, an inhibitor of mitogen-activated protein kinase kinase, U0126, attenuated tumor proliferation

These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular The Beaulieu group is presently investigating how cell surface express proteins can act as allosteric These investigations have led to the identification of an RNA binding protein (FXR1P) involved in the regulation of protein synthesis as a potential downstream effector of the action of mood stabilizers

Craig Malbon at SUNY Stony Brook studying the role of G-protein coupled receptors (GPCRs) and their regulators Senthil Muthuswamy at Cold Spring Harbor Laboratory and probed the roles of polarity proteins (Feigin They also discussed his research on cell polarity and its role in cancer progression, his work on G-protein He also discussed his work on G-protein coupled receptors (GPCRs) in breast cancer, identifying GPR161 Challenges Mike shared significant moments in his scientific journey, including the discovery of RGS proteins

alizarin red S staining and detecting the changes of ALP and runt-related transcription factor 2 (RUNX2) proteins immunoprecipitation (RIP), and pull-down assays were used to confirm the binding between miR-708-5p and circFKBP5 or G-protein-coupled receptor (GPCR)-kinase interacting protein 2 (GIT2). LPS induced miR-708-5p expression in hDPSCs, and knockdown of miR-708-5p protected against LPS-evoked Rescue experiments showed that GIT2 could mediate the protective functions of circFKBP5 on hDPSCs under

PRL3 in pediatric tumors in relation to survival outcomes, expression of angiogenesis markers, and G-protein-coupled receptor (GPCR)-mitogen-activated protein kinase (MAPK) signaling targets. profiling of PRL3-positive tumors showed elevation of angiogenin, TIMP1 and TIMP2, and GPCR-MAPK signaling proteins

In this study, we aimed to integrate the genetic alterations, protein expression profiles, transcriptomes Targeted capture sequencing and copy number analysis of 36 genes and nontargeted proteomics analysis between the proteome and the transcriptome. Gene ontology analysis was performed for differentially expressed proteins between wild-type and mutant GNAS samples identified by nontargeted proteomics and involved in G protein-coupled receptor (GPCR)

salmoides) Published date October 24, 2024 Abstract "CC chemokine receptors (CCRs), the numbers of the G protein-coupled receptor (GPCR) superfamily, had crucial roles in treating infection, inflammation, and

Available for AGPCR24 Attendees About Jin-Peng Sun "Since starting my laboratory in 2011, I has focused on G protein coupled receptors, in particular, the ligand identification, physiological functions and molecular For arrestin mediated biased signaling, we have proposed the “flute model” and “poly proline region docking

Planar cell polarity (PCP) proteins contribute to tumour growth and invasion. protein-coupled receptor involved in diverse biological processes. are members of group VII of the adhesion G protein-coupled receptor (aGPCR) family. possible connection between BAI3 and ß-catenin signaling through MAGI3 in WNT-MB, we probed for potential protein-protein Kordon Abstract "Adhesion G Protein-Coupled Receptors (aGPCRs) are key cell-adhesion molecules involved

August 29, 2024 Abstract "The growth hormone-releasing hormone receptor (GHRHR) belongs to Class B1 of G protein-coupled receptors (GPCRs).

NPFF regulates a variety of physiological functions by binding to a G protein-coupled receptor (GPCR)

Long-COVID is currently under heavy scrutiny and existing data on the role of auto-immune reaction to G-protein

Additionally, among examined G protein-coupled receptor (GPCR) genes, exposure to CPPDQ (0.01-10 μg/L

G-protein-coupled receptors (GPCRs) are the most intensively studied drug targets but are underexplored