August 2022 "Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealized, therapeutic potential. Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Symposia 2023. Adhesion GPCRs CryoEM structures of adhesion in GPCR CD97: Filling in some of the gaps GPCR Activation identification of potential agonists of FFAR4 for type 2 diabetes mellitus therapy Industry News OMass Therapeutics (ANDA) Litigation PostEra Announces a Research Collaboration with Amgen to Discover Small Molecule Therapeutics GPCR Ecosystem

Hello GPCR people! We have great news! Take a few minutes, and dive into our GPCR coverage! We welcome GPCR paper suggestions! Adhesion GPCRs The Posttraumatic Increase in the Adhesion of GPCR EMR2/ ADGRE2 to Circulating Neutrophils Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation GPCR Activation and Signaling GPCR Ecosystem

Are you ready for some exciting news in the GPCR world? This week's highlights: Dr. GPCR Symposium of the year on GPCRs in Immunology and Oncology! GPCR Newsletter for more insights! Company in Immuno-Oncology, Domain Therapeutics, Presents Groundbreaking Advancements at ESMO 2023 Novo GPCR Ecosystem

While GPCRs can exist as monomers, some types, like class C GPCRs, are obligate dimers, either as homodimers Class B1 GPCRs are an important subclass of GPCRs that include 15 receptors involved in regulating body for our understanding of GPCR function and signal transduction. for developing therapeutic agents that target specific receptor dimer states to modulate signaling in Graaf, C., et al., Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic

November 2022 "Adhesion G-protein-coupled receptors (aGPCRs) play key roles in a diversity of physiologies A hallmark of aGPCR activation is the removal of the inhibitory GAIN domain and the dipping of the cleaved The structures also reveal the uncharted structural information of GPCR/G12 coupling. Taken together, our study lays the groundwork for understanding aGPCR activation and G-protein-coupling Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Dr. GPCR Newsletter HERE

GPCR Newsletter to receive more insights! Adhesion GPCRs Piconewton Forces Mediate GAIN Domain Dissociation of the Latrophilin-3 Adhesion GPCR Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs GPCR Activation Tethered Ligands that Target the µ-Opioid Receptor Design and Synthesis of Novel GPR139 Agonists with Therapeutic GPCR Ecosystem

We will be back next week with our regular weekly GPCR news digest. In the meantime, you can always check the  Classified GPCR News from the last weeks. GPCR Podcast. GPCR. Today is also the first session of our hands-on workshop with Dr. Sam Hoare. GPCR University content coming soon.

GPCR Symposium about 'GPCRs as Therapeutic Modalities' rocked it! GPCR Newsletter! Dive into the Classified GPCR News from September 18th to 24th, 2023. recommended by NICE for acute migraines Addex mGlu2 NAM Cognition Program Receives €4 Million Grant Confo Therapeutics Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting GPCR Ecosystem

GPCR podcast with Dr. Nicole (Nicki) Perry-Hauser is now available What a fun chat! GPCR Ecosystem paid membership to enjoy everything Dr. GPCR has! ➡️https://bit.ly/3TCJVQQ #gpcr #drgpcr

AlphaFold, homology modeling was the most common method for predicting G protein-coupled receptor (GPCR GPCRs are dynamic, switching between multiple conformations, and many have only distant homologs with The introduction of AlphaFold2 marked a major advancement in the field of GPCR structure prediction. While AlphaFold2’s ability to predict static structures was groundbreaking, however, GPCRs are highly crucial for understanding how drugs can selectively target different receptor conformations to achieve therapeutic

Our partner, Domain Therapeutics, will attend the SACHS 23rd annual biotech event in Europe. Dr. Christopher Langmead and colleagues' work on the 5-HT2C receptor as a therapeutic target for substance GPCR Symposium on ''GPCRs as Therapeutic Modalities' Share your project with a 1-minute abstract video Protein and Exendin-P5 Biased Agonist Molecular and structural insights into the 5-HT2C receptor as a therapeutic teams up with addiction treatment maker Indivior to make digital therapeutics for substance use disorders

GPCR Symposia Mark your calendars! GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs Reviews, GPCRs, and more Butyrate as a promising therapeutic target in cancer: From pathogenesis to cadherin G protein-coupled receptors that bind cry toxins of Bacillus thuringiensis Industry News Domain Therapeutics GPCR Ecosystem

Human cells express over 800 G-protein-coupled receptors (GPCRs) to facilitate communication with the Capturing the dynamics of GPCR activation has always been a challenge because G protein activation in With this high-resolution, dynamic view of GPCR activation, scientists can better tackle diseases by puzzles and underscores the importance of understanding cellular processes at the molecular level for therapeutic Time-resolved cryo-EM of G-protein activation by a GPCR. Nature (2024).

in the GPCR field. GPCR Symposium on 'GPCRs as Therapeutic Modalities'. neutrophil chemoattractant Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic Launches with $33 Million Seed Round to Fuel its Drug Discovery Engine and Pipeline of Small Molecule Therapeutics GPCR Ecosystem

ligands Essentials for effective GPCR discovery Discover: Advanced cellular assays for GPCR ligand behavior GPCR Event Highlight Join us in vibrant Mexico City from October 23-25, 2024, for the 11th Adhesion GPCR Let’s dive into the Classified GPCR News from July 22 to 28, 2024 GPCR Activation and Signaling Activating oligomers in live cells Industry News Confo Therapeutics Announces EUR 60M Series B Financing to Advance GPCR Ecosystem

Xavier Leroy for his new role as CEO of GIO Therapeutics Dr. at the plasma membrane Industry News Launch of GIO Therapeutics, founded by Cumulus Oncology, to develop therapeutics targeting G protein-coupled receptors to treat cancer and inflammation AVROBIO and Tectonic Therapeutic Announce Merger Trevena Inc Elevates Barry Shin to Executive VP and CFO GPCR Events, Meetings GPCR Ecosystem

February 2022 Septerna emerges with $100M to spark 'second golden age' of prolific drug target GPCR with Better known as GPCR, the fruitful research space has led to more than 700 approved drugs over previous The company's co-founder, GPCR pioneer and Nobel laureate Robert Lefkowitz, M.D., has 50 years of experience Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Symposium on 'GPCRs as Therapeutic Modalities'. Want to share your project in a casual way? GPCR Newsletter! npr-38 regulates avoidance and stress-induced sleep in Caenorhabditis elegans Towards the convergent therapeutic Provides Corporate Updates, and Reports Emerging Data from Chronic Neutropenia Clinical Program Structure Therapeutics GPCR Ecosystem

2022 Sosei Heptares and Kallyope Enter Collaboration to Identify and Validate Novel Gastrointestinal GPCR leverage multiple sophisticated technologies that drive creation of new drug discovery programs in key therapeutic the Sosei Heptares compound library for its industry-leading biology platform to identify potential GPCR targets and advance the development of new gastrointestinal therapeutics Tokyo, Japan, Cambridge, UK drug discovery programs in the area of gastrointestinal diseases. " Read more at the source #DrGPCR #GPCR

GPCR Symposium on Structural and Molecular Insights on GPCR Activation! GPCRs in Cardiology, Endocrinology, and Taste Clinical, Pathophysiologic, Genetic, and Therapeutic Progress Medicines OMass Therapeutics was shortlisted for ‘Life Sciences and Health Tech Company of the Year’ Directors Crinetics Pharmaceuticals Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) Confo Therapeutics GPCR Ecosystem

September 2022 "Background G protein-coupled receptor (GPCR) is the most targeted protein family by the GPCR-kinase 3 (GRK3) is critical for GPCR signaling. Read more at the source #DrGPCR #GPCR #IndustryNews

Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR University 🎥 Access to the recorded classes of GPCR Courses and talks from Symposia 💲 Discounted GPCR courses GPCR Forum Initiate a vibrant conversation or seek assistance GPCR Events to keep you Arm's Race' Developments Five protein-design questions that still challenge AI Prix Galien USA: Domain Therapeutics Nominated for the Prestigious Best Startup Award Tectonic Therapeutic Announces Positive Phase 1a Results Jobs Scientist I Cell Biology - Tectonic Therapeutic NEW Senior Principal Scientist, Medicinal Chemistry

Greetings GPCR enthusiasts! Join us to explore the fascinating world of GPCRs. GPCRs in Neuroscience Orphan receptor GPR88 as a potential therapeutic target for CNS disorders - an Industry News Coherus to Acquire Surface Oncology Confo Therapeutics and AbCellera partner on GPCR-targeting Patent in Japan Proteros Biostructures GmbH Revolutionizes Metabolic Disorder Treatments Structure Therapeutics (June 28 - 30, 2023) NEW FREE Seminar Antibodies targeting Membrane Proteins - From Antigen to New Therapeutics

Get ready for an expedition, GPCR explorers! Welcome back to your weekly GPCR quest! Classified GPCR News  Let’s dive into the   Classified GPCR News from October 21st to 27th, 2024 Industry Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and Therapeutic PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate

Hello GPCR enthusiasts! We're here to share the latest GPCR news with you. Congratulations to Dr. GPCR Symposium on Structural and Molecular Insights on GPCR Activation is quickly approaching! GPCR Newsletter for updates! Structural and Molecular Insights into GPCR Function Dual mechanisms of cholesterol-GPCR interactions GPCR Ecosystem

Hi there GPCR enthusiasts! Join us this week for a deep dive into the world of GPCRs. GPCR Symposium on Structural and Molecular Insights on GPCR Activation. Novartis bolsters innovative medicines strategy and renal pipeline with agreement to acquire Chinook Therapeutics Confo Therapeutics Enters Into Research Collaboration For GPCR-Targeting Antibody Discovery With AbCellera GPCR Ecosystem