GPCR AI Summary AI-generated content may be inaccurate or misleading. Always check for accuracy. Yamina expressed a desire to learn from successful leaders and the importance of recognizing talent and

was made possible by the optimization of longitudinal intravenous self-administration paradigms for genetically Slosky is passionate about training the next generation of scientists and increasing diversity, equity

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To address this, we developed the NTF release sensor (NRS), a genetically encoded reporter that facilitates Upon NTF dissociation, an intracellular transcription factor (reporter module) is released, generating Marguerite; Langenhan, Tobias; Scholz, Nicole Rudolf Schönheimer Institute of Biochemistry, Divison of General adhesion GPCR Signaling and Pharmacology-Enabling Drug Discovery Laurent Sabbagh Abstract "The 3rd generation

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gradients of chemokines and other chemoattractants, it remains poorly understood how these gradients are generated demonstrate that in addition to its role as the sensory receptor that steers migration, CCR7 also acts as a generator We further show that these self-generated gradients can sustain the long-range guidance of DCs, adapt

Here, we showed that genetic activation of the orphan GPCR GPR132 significantly induced cell differentiation activation by 8GL promoted differentiation and reduced colony formation in human AML cell lines with diverse genetic Notably, genetic or pharmacological activation of GPR132 triggered the differentiation of human primary

also observed PTX-dependent TNT biogenesis in response to lysophosphatidic acid (LPA), indicative of a general TNT generation by either 5-oxo-ETE or LPA is partially dependent on the transactivation of the epidermal o-coupled GPCRs and TNT development, and sheds light into the intricate signaling pathways governing the generation

A2B G protein-coupled receptors is increasingly recognized as an important immune checkpoint in the generation of the Scientific Advisory Board (SAB) of Surface Oncology, a clinical stage company developing next generation

role of steroidogenesis in regulating sexual determination and adrenal and gonadal development using genetic modifying proteins in vascular biology, the Caron laboratory has gained valuable insights into the genetic

Genetic variants in RGS proteins are associated with many diseases, including cancers, although the impact SIGNIFICANCE STATEMENT: Human genetic variant/mutation information has expanded rapidly in recent years the novel bioinformatics tool three-dimensional missense tolerance ratio (3DMTR) to define regions of genetic

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role of steroidogenesis in regulating sexual determination and adrenal and gonadal development using genetic modifying proteins in vascular biology, the Caron laboratory has gained valuable insights into the genetic

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He finished his career as Head of Bioinformatics for Neuroscience and working on the GSKs novel genetics

postdoctoral fellow at the Vanderbilt Center for Neuroscience Drug Discovery, the National Institute of General

for GPCRs and since have branched out to multiple areas of GPCR research such as sequence alignments, generic

He is a first-generation college graduate and academic.

for GPCRs and since have branched out to multiple areas of GPCR research such as sequence alignments, generic

contain adhesion GPCRs Avoid copyrighted material unless a CC BY / open-use license has been acquired or generated

His experience also includes translating knowledge generated into the selection of targets, screening

at the MRC Laboratory of Molecular Biology in Cambridge, UK, where he was working on the impact of genetic

after was recruited to the Medical Faculty of Leipzig University, where I now head the Department of General

General Research Interest: The focus in the Schulte lab is on Frizzled signaling and pharmacology aiming

In addition, I generated various optical biosensors based on fluorescence or bioluminescence resonance