Find speaker details on the Live Talks page and mark your calendar HERE. exchange factor RIC-8 regulates cilia morphogenesis in Caenorhabditis elegans sensory neurons CaSR links Binders, Drugs, and more Cloning and deorphanization of three inotocin (insect oxytocin/vasopressin-like & Updates in GPCR Research Mining the ZINC database of natural products for specific, testosterone-like Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

Find speaker details on the Live Talks page and mark your calendar HERE. cell mobilization when combined with propranolol Discovery of 3-Phenyl Indazole-Based Novel Chemokine-like progress Industry News Anatole Klepatsky, Orion's COO, Shared Innovative Insights at LSBC Central European Life Meeting February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

Unlike orthosteric ligands that bind directly to the receptor's active site, allosteric modulators target functional and/or affinity for an orthosteric ligand; and negative allosteric modulators (NAMs), that fully or partially dampen the receptor's functional response to the ligand (Wold, Chen et al. 2019). site without causing any detectable alterations in the receptor or orthosteric ligand behavior (Lindsley and NAMs and thereby blocks the effects of positive and negative allosteric modulators (Rodriguez, Nong

You can find more information about them on the Live Talks page and mark your calendar HERE. β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor An siRNA library proliferation in white matter injury via Hedgehog-independent CREB signaling Ciliary localization of a light-activated Meeting February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

the Gαi3 heterotrimers Activation/Deactivation Free-Energy Profiles for the β2-Adrenergic Receptor: Ligand ascosporogenesis in the wheat scab fungus GPCR Binders, Drugs, and more Development of Photoswitchable Tethered Ligands Meeting February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

silico identification of a biarylamine acting as agonist at human β3 adrenoceptors and exerting BRL37344-like Endothelin-B receptor probes GPCRs in Cardiology, Endocrinology, and Taste GPRASP1 loss-of-function links malformations by endothelial activating GPR4 signals GPCRs in Neuroscience Involvement of a silkworm D2-like Meeting February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

by NMR spectroscopy with stable-isotope labeled receptors GPCR Binders, Drugs, and more Orthosteric ligand immunodeficiency G protein-coupled receptors: A target for microbial metabolites and a mechanistic link Meeting February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

Meeting February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

Meeting February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

Serotonin signaling regulates actomyosin contractility during morphogenesis in evolutionarily divergent lineages Immunology [1,2,4]Triazolo[1,5-c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer Cell Lines Severity of neurological long-COVID symptoms correlates with increased level of autoantibodies targeting Molecular Insights into GPCR Function Structure and Molecular Mechanism of Signaling for the Glucagon-like Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

Meeting February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating

mechanisms and therapeutic targets in atopic diseases Methods & Updates in GPCR Research TrGPCR:GPCR-ligand NEW February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition NEW March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar NEW March 24 - 29, 2024 | Ligand Recognition and Molecular

Classified GPCR News from August 14 to 20, 2023 Adhesion GPCRs Amelioration of non-alcoholic fatty liver Single-molecule analysis reveals that a glucagon-bound extracellular domain of the glucagon receptor is dynamic Ligand compromised GPCR signaling in diverse cancer cells GPCRs in Neuroscience Neurotensin receptor 1-biased ligand feed-forward activation of the SK1-S1P1 signaling axis Methods & Updates in GPCR Research Magnetic Liposomes

and First Half of 2023 Novo Nordisk to acquire Inversago Pharma to develop new therapies for people living

GPR84 GPCR Binders, Drugs, and more Computational Peptide Design Cotargeting Glucagon and Glucagon-like

We'll be sharing the list of our confirmed speakers soon! Monoacylglycerol Lipase Protects the Presynaptic Cannabinoid 1 Receptor from Desensitization by Endocannabinoids

Methods & Updates in GPCR Research Fluorescent Ligands Enable Target Engagement Studies for the Intracellular Reviews, GPCRs, and more Interplay of thermodynamics and evolution within the ternary ligand-GPCR-G protein

Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase. Financing to Advance Pipeline of Novel GPCR-targeted Medicines OMass Therapeutics was shortlisted for ‘Life Poon to Board of Directors Crinetics Pharmaceuticals Announces Inducement Grants Under Nasdaq Listing

and Signaling G protein activation via chemokine (C-X-C motif) receptor 4 and α1b -adrenoceptor is ligand GPCR targeting of E3 ubiquitin ligase MDM2 by inactive β-arrestin. Methods & Updates in GPCR Research Profiling of basal and ligand-dependent GPCR activities by means of

GPCR Partner, GPCR Therapeutics, for passing the Technology Evaluation process for listing on the KOSDAQ Specialized Pro-resolving Lipid Mediators and Resolution of Viral Diseases. GPCR Therapeutics passes the Technology Evaluation process for listing on KOSDAQ.

But before we delve into the latest news, we'd like to highlight some upcoming events and resources: Japan Proteros Biostructures GmbH Revolutionizes Metabolic Disorder Treatments Structure Therapeutics listed

Ines Liebscher, Ross Cheloha and Silvio Gutkind. Before we dive into this week’s news, we’d like to draw your attention to some of our events and resources Adhesion GPCRs Collagen VI Is a Gi-Biased Ligand of the Adhesion GPCR GPR126/ADGRG6. GPCR Binders, Drugs, and more Adenosine A2A Receptor (A2AAR) Ligand Screening Using the 19F-NMR Probe Structural and Molecular Insights into GPCR Function Structural insights into ligand recognition and

If you'd like to showcase your work, please email us at Hello@DrGPCR.com. We would also like to take a moment to thank the organizers for inviting Dr. NMR applications to GPCR recognition by peptide ligands. Application of computational methods for class A GPCR Ligand discovery. New paradigms in purinergic receptor ligand discovery.

You can now watch the live talk recordings from the previous symposiums, check them out here. Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells

At the cellular level, the plasmatic membrane is a thin layer of lipids that surrounds the entire cell The physical barrier this lipid bilayer creates is dynamic and interactive, becoming the foundation for The cellular membrane's composition, organization, and physical properties might impact ligand binding bilayer likely contributes to stabilizing β-arrestin in a membrane-bound, active-like conformation. They shed light on the essential role of β-arrestin binding to the lipid bilayer for efficient interaction

If you are interested in giving a talk, contact us at Hello@DrGPCR.com, and if you would like to present GPCR Activation and Signaling Monitoring the Reversibility of GPCR Signaling by Combining Photochromic Ligands GPCRs in Neuroscience Conformationally Selective 2-Aminotetralin Ligands Targeting the alpha2A- and alpha2C-Adrenergic (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference.

GPCR Activation and Signaling Ligand-induced activation and G protein coupling of prostaglandin F2α receptor (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference.

Artificial intelligence - Machine learning vs Deep Learning GPCRs have long been recognized as important GPCR-ligand interactions: ML can predict GPCR-ligand interactions based on input data of protein sequences receptors (He, Ben, Kuang, Wang & Kong, 2016; Kuang, Feng, Hu, Wang, He & Kong, 2016). 5. Paremeters such as ligand affinity for the receptor (pKi), the ability of a ligand to induce or inhibit a cellular response (pEC50 or pIC50, respectively), and how long the ligand remains bound to the receptor