GPR125 (ADGRA3), an orphan adhesion GPCR, has been shown to modulate planar cell polarity in gastrulating zebrafish, but its biochemical properties and role in mammalian cells have remained largely unknown.

However, the potential role of GPR3 in axonal regeneration after neuronal injury has not been elucidated

Prof Pfleger has served on the ASCEPT Board since 2016 and was Chair of the Scientific Advisory Committee

strain of the virus was first identified in South Africa in early November, and an existing treatment has

A conserved intracellular allosteric binding site (IABS) has recently been identified at several G protein-coupled

However, recent studies have unveiled a complex layer of GPCR functioning, introducing the concept of This has significant implications for drug development, as targeting these non-cognate interactions could

The experimental structure of these receptors has yet to be determined, and key-residues controlling

, controversy remains regarding its role in breast cancer since both pro- and anti-metastatic roles have In KISS1R overexpressing triple-negative breast cancer (TNBC) cells, stimulation has been associated

of GPCRs contributes to neuronal coding and behavioral output under physiological conditions in vivo has Finally, muscarinic receptor voltage independence causes a strong behavioral effect of increased odor habituation

Recently, it has been shown that murine Latrophilins mediate classical G-protein signals to drive synaptogenesis

succeed through its offering of high-quality synthetic DNA using its silicon platform, today announced it has In addition, Revelar will have the ability to leverage the antibody discovery and optimization platform

The recognition that GPCRs may physically interact with each other has led to the hypothesis that their

We have 15 GPCR papers, three industry news, and two job ads.   Topics include the complex pleiotropic behaviors of GPCRs and how these can be harnessed for innovative the δ opioid receptor (DOR): A computational study with structural approach Mechanisms controlling haemolymph of the free fatty acid receptor 4 as a regulator of food and water intake The tick Ixodes scapularis has

The biased signaling modulation of non-GPCR receptors has yet to be exploited.

Although less characterized, canonical chemokine receptor systems have been also shown to not only directly of clathrin-mediated endocytosis (CME) did not affect the ability of CCR2 to scavenge chemokine and had canonical chemokine receptors Clearing circulating chemokines and chemokines from tissue microenvironments has However, this scavenging role has been also described for several canonical chemokine receptors, including But why do canonical chemokine receptors have this dual role in physiology?

Sir William Osler Scientists have long sought to discover a “golden bullet” that would cure every disease Notably, G-protein-coupled receptors (GPCRs), representing the biggest drug target, have been revealed This emphasis may have caused other signaling pathways to be overlooked due to a need for adequate assay Recent research has unveiled the emergence of G-protein-independent pathways, particularly those involving Recently, several high-throughput screening (HTS) assays for ERK activation have been developed, each

well-established field, recent technological advances to dissect the molecular mechanisms of GPCR function has

showed how the Stalk region, which is a short peptide released from the GAIN during auto-proteolysis, has Fortunately, the scientific community has become increasingly interested in studying these proteins and Different studies have shown that aGPCRs such as Lphns have promiscuous behavior, where in a constitutive close analysis of the different Cryo-EM receptor structures with Gq, Gs, Gi and G12 showed that Gq/Gs have despite their broad physiological importance in normal and pathological processes, so far no drugs have

We had an amazing week. Don’t miss out on our GPCR coverage for this week. We have 10 GPCR papers, five industry news, and one job ad. from Gαi3 research GPCRs in Cardiology, Endocrinology, and Taste The Prostaglandin E2 EP3 Receptor Has

SSAs regulating SST2 and SST5 homo- and hetero-dimer formation "The process of GPCR dimerization can have far, the existence and physiological relevance of SSTs homo- and hetero-dimerization in the pituitary have may play modulatory effects and whether FLNA may participate to this level of receptor organization have epitope tagging, we detected homo-dimers of human SST2 in GH3, A7, and M2 cells transiently co-expressing HA

Earlier publications have indicated that expression of CB1 receptor mRNA and protein has been recognized Skeletal muscle cells have often been used; it is well-documented that they express cannabinoid receptors were recognized to be important moderators of NR4A1 and NR4A3 mRNA gene expression; these actions may have

OR expression outside of the nose has functions distinct from odor perception, and may contribute to

We have 15 GPCR papers, two industry news, and one job ad. You have until 5 pm EST tomorrow to register. GPCR University hands-on workshop with Dr.  Our Chief Matchmaker, Mark Schmeizl, had a great conversation about this position with Beth Fleck, Director Mark has experience connecting candidates with employers and will work with you to understand your needs

We have some exciting updates for all the GPCR enthusiasts out there. Additionally, we have six industry news. You have until May 3rd, 2023 to register. GPCR University hands-on workshop with Dr.  Mark has experience connecting candidates with employers and will work with you to understand your needs

8th, 2024 Industry News Superluminal Medicines Closes $120 Million Series A Round Domain Therapeutics has ushers in a new frontier in fragment and small molecule drug discovery Is the pharma community looking hard This technique for studying cell receptors could have sweeping implications for drug development DeepCure HIGHLIGHT Research Associate - Professor Graeme Milligan HIGHLIGHT Postdoc in Molecular Pharmacology - The Hauser

Highlights: Congrats to: Ya-Tzu Li , our notable contributor, for her superb undergrad paper along with Hao-Jen From 2025, only Premium Members will have access to Classified GPCR News. Antibody Therapeutics Using Generative AI Zombie Fungi Hijack Hosts’ Brains GPCR Therapeutics, Inc. has Approaches in GPCR Drug Discovery NEW February 15 - 19, 2025 | BPS 2025 NEW February 16 - 21, 2025 | Harnessing Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser

discrimination of closely related pheromones in Schizosaccharomyces pombe Most sexually reproducing organisms have receptor systems are likely to function in both mate choice and prezygotic isolation, very few studies have The fission yeast Schizosaccharomyces pombe has two mating types, Plus (P) and Minus (M).

Unfortunately, registration has closed, but you can still join the waitlist by emailing gpcrretreat@uottawa.ca to Vertex for $48 million Merck KGgA collaborates with Exscientia plc in deal worth up to $674M 2023 Half-Year