this study, we investigated the effects of THC and CBD on the differentiation of MECs by assessing changes

Conformational changes that facilitate scrambling are distinct from those associated with GPCR signaling

The changes in amyloid pathology are accompanied by robust microglial and astrocytic hypertrophy, which

molecular diversity of GPCR signaling systems is likely to be closely associated with disease-associated changes

2000), becoming incapable of promoting cell migration, a phenomenon which is likely to be mediated by changes

In all cases, the receptor interaction changes downstream signalling and the responses to receptor agonists

Structural analysis of SMO domains shows significant changes in the CRD and ICD, during the course of

Here, we investigate the conformational changes induced by the binding of a nanobody (Nb80) on the active-like

This paper thoroughly investigated the role of single amino acid changes to clarify the molecular mechanisms

., Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface determine

receptor-Gi complex in a conformation stabilized by unique NPxxL motif Ligand-induced conformational changes

announced the winners of its Transforming Cancer Therapeutics grant, which focuses on developing life-changing

2000), becoming incapable of promoting cell migration, a phenomenon which is likely to be mediated by changes

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, such as ligand binding sites (orthosteric, allosteric), activation mechanisms, and conformational changes

These interactions induce local conformational changes which are amplified and transmitted to the intracellular the fully integrated PROcisionXᵀᴹ discovery platform Structure-based validation of Orion’s approach Zheng