perception, transmission, and feedback are all rely on a signal network that constituted by membrane receptors Here we show that the G protein-coupled receptor (GPCR) to cAMP pathway is responsible for transmitting Liu, Yuxin Jin, Yunbo Luo, Kunlun Huang, Zhihong Liang Tags Cell communication , G protein-coupled receptor

fibrosis in a murine model with fibrotic bone Published date May 1, 2024 Abstract "G protein-coupled receptors mice, in which Gs-GPCR signaling was hyper-activated in osteoblastic cell lineages using an engineered receptor fibrotic bone disease , fibrous dysplasia (FD) , osteoblasts , trabecular bone , G-protein coupled receptor

peptide agonist mechanism that differed from the common example known at the time, protease activated receptors Adhesion GPCRs pre-cleave themselves and the two resultant fragments of the receptor remain together adhesion GPCRs in complex physiological contexts…one being our discovery that GPR56 is the platelet receptor

Immunology Prediction of survival and immunotherapy response by the combined classifier of G protein-coupled receptors Zhang , Yu Zhu , Jia Feng , Feng Qin , Yanwen Yang , Chuanyuan Wei , Jianying Gu Tags G protein-coupled receptors

< GPCR News < GPCRs in Oncology and Immunology Lactate receptor GPR81 drives breast cancer growth and properties and Notch ligand DLL4 Published date November 22, 2023 Abstract " Background: The lactate receptor

Immunology Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Moreover, the GBP2-induced response was silenced by pre-treatment with dsRNA targeting the GBP receptor

GPCRs in personalized cancer therapy Published date September 12, 2024 Abstract "G protein-coupled receptors (GPCRs) are vital cell surface receptors that govern a myriad of physiological functions.

developing a powerful new computational tool for identifying ‘surrogate’ ligands (borrowed from other receptors this expertise to establish a research program that takes orphan GPCRs from ‘locked’, inaccessible receptors

Mark von Zastrow where she identified novel core cellular machinery critical for G protein-coupled receptor cell biological mechanisms regulating GPCR activity, including spatial control of GPCR signaling and receptor

Ph.D. from Department of Pharmacology, University of Washington (1992, mentor Charley Chavkin , sigma receptors Focus on study of drugs and toxins on GPCR (opioid, cannabinoid receptor) and ion channel (K, Ca, TRP

Antibody-drug conjugates targeting CD97 in glioblastoma Dimitris Placantonakis Adhesion G protein-coupled receptor localized in the developing and adult synapses and interact with synaptic scaffold proteins and glutamate receptors Several adhesion G protein-coupled receptors (aGPCRs) have recently been shown to play critical roles Dimitris Placantonakis on the web Placantonakis Lab Google Scholar LinkedIn Adhesion G protein-coupled receptor endeavoring to build a productive, independent scientific research career in adhesion G protein-coupled receptor

GPCR Retreat Program < Back to schedule Structure-based discovery of functionally selective 5-HT1A receptor

< GPCR News < GPCRs in Oncology and Immunology Protease-Activated Receptor-1 IgG Autoantibodies in Patients

< GPCR News < GPCRs in Oncology and Immunology Autocrine proteinase-activated receptor signaling in PC3

obtained his Ph.D. from the University of Manitoba – Canada, where he was introduced to G protein-coupled receptors His doctoral research focused on the structural and functional characterization of bitter taste receptors

Blanco Redondo Abstract "The Drosophila genome contains five loci encoding adhesion G-protein coupled receptors remoulade (remo) gene is a homologue of the vertebrate aGPCR ADGRA family, sharing the same overall receptor We found that the receptor is cleaved despite the lack of a consensus GPS sequence. Langenhan where I am studying and characterizing newly generated adhesion GPCR receptors in Drosophila

G protein-coupled receptors (GPCRs) mediate a vast variety of critical biological processes and provide for quantitative, and multi‐scale integration of these amounts of data to gain novel insights into receptor

Chemokine-mediated neutrophil recruitment is determined by Cxcr2 receptor signaling, Cxcr2 endocytosis These data collectively indicate that optimal glycosaminoglycan interactions and dampened receptor activity

Xu et al. identified the mammalian neurokinin 3 receptor (TACR3), a homolog of the G protein-coupled receptor TkR99D in fruit flies, as a potential therapeutic target for alleviating renal tubular dysfunction

GPR37 is an orphan G protein-coupled receptor (GPCR) that is implicated in different physiological pathways positive regulation of macrophage derived foam cell differentiation, negative regulation of T cell receptor signaling pathway, neuroactive ligand receptor interaction, calcium signaling pathway, and negatively

Neuroscience at the University of Ottawa as a Postdoctoral Fellow to explore novel G protein-coupled receptor at The Rockefeller University, where she study’s the signaling and degradation of G protein-coupled receptors to understand the mechanism by which a new class of biased allosteric modulators for the neurotensin receptor

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GPCR News < GPCRs in Oncology and Immunology [Inhibitory effect of downregulating G protein-coupled receptor date March 27, 2024 Abstract "Objective: To clarify the effect and the mechanism of G protein-coupled receptor gingival fibroblasts (GFs), thus to provide a foundation for delving into the role of G protein coupled receptor

homodimer Published date June 19, 2024 Abstract "GPRC5D is an atypical Class C orphan G protein-coupled receptor Despite its therapeutic potential, the insufficient understanding regarding of the receptor's structure

Since 2013, he has been elected Chair of the subcommittee for the Dopamine receptors of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification

and received my Ph.D. in Molecular Medicine in 2010 after studying the orphan atypical cannabinoid receptor I studied the function of RGS5, calcium-sensing receptor, and an orphan adhesion GPCR, GPR64/ADGRG2 in

in inflammatory diseases and cancers Published date March 15, 2023 Abstract " C-X-C motif chemokine receptor 2 (CXCR2) is G protein-coupled receptor (GPCR) and plays important roles in various inflammatory diseases

With a special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular