Search Results
197 items found for "POTS"
- Platelets in the NETworks interweaving inflammation and thrombosis
Here, virus infiltration may lead to a cytokine storm that potently activates neutrophils and leads to In this review, we will discuss the interplay between platelets and NETs and the potential of this alliance
- A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation
homodimerization has a setmelanotide-like effect on Gq/11 signaling, with chimeric receptors presenting increased potency These findings indicate the potential of inhibiting MC4R homodimerization as a therapeutic target to
- Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but...
familial hypocalciuric hypercalcemia type-1 (FHH-1), supported maximal signaling with reduced Ca2+o potency Thus two WT VFT domains were required for normal Ca2+o potency and there was a pronounced gene-dosage
- GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation
of GPR84 in innate immune cells and intestinal inflammation, and suggest that GPR84 may serve as a potential
- Molecular insights into regulation of constitutive activity by RNA editing 5HT2C serotonin receptor
These 5HT2C isoforms display differences in constitutive activity, agonist/inverse agonist potencies,
- High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and...
results may supply new insights into GPER-mediated estrogen carcinogenesis in TNBC, thus providing a potential
- Interacting binding insights and conformational consequences of the differential activity of...
pave the way for understanding the CBD pharmacology at a molecular level and aid in harnessing its potential
- GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to...
their response to paclitaxel by forming a vicious cycle with IGF1/IGF1R signaling pathway "There is a potential interacting with and stabilizing IGF1R, and suggests that it may serve as a valuable prognostic factor and potential
- Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
Inhibiting overactive SHH signaling may be a potential neuroprotective therapy for sPD."
- Identification and functional characterization of the sulfakinin and sulfakinin receptor in the...
that the SK signal pathway plays a positive and significant role in feeding regulation and provides a potential
- PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer
Here, we find that protease-activated receptor 4 (PAR4) unexpectedly acts as a potent oncogene, inducing
- Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation...
eosinophilic CRS (ECRS) via macrophage IL‐1β overproduction, thereby suggesting autophagy regulation as a potential We sought to investigate the therapeutic potential of autophagy‐enhancing agent, trehalose, or related
- Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells...
Previously, we identified potent positive crosstalk between insulin/IGF-1 receptors and G protein-coupled A combination of dasatinib and trametinib potently and synergistically inhibited colony formation by
- Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal...
We envision that our results could have potential implications in structural biological advancements
- Immunomodulatory Role of Neuropeptides in the Cornea
the homeostasis of the ocular surface, alterations in disease settings, and the possible therapeutic potential
- GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer
September 2022 "GPCRs are the most potential targets for drug discovery, however, their role in oncology Herein, we identified GPR108, a GPCR protein described in innate immune system, is a potential therapeutic
- The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells
recognized within myotubes and tissues of skeletal muscle from both murines and humans, thus representing a potentially
- Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases
Therefore, mGluR2 and mGluR3 have been considered as potential drug targets for the treatment of many
- Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors
naloxone from an inhibitor directly into an agonist of MOR, and I322A also significantly attenuated the potency
- The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?
Ras homolog family member A (RhoA), exchange protein activated by cAMP (Epac), and transient receptor potential
- Addex Therapeutics CEO Tim Dyer: There is a $4-bil market opportunity in dyskinesia
Dyer provides an overview of our #allostericmodulator pipeline and the potential $4 billion market for
- Exscientia and Sanofi Establish Strategic Research Collaboration to Develop AI-driven Pipeline ...
oncology and immunology Exscientia will receive an upfront cash payment of $100 million with the potential
- Trevena Announces Advancement of TRV045 Into Clinical Development for Diabetic Neuropathic Pain
TRV045 is the Company’s novel S1P1 receptor modulator being developed as a potential treatment for diabetic through a collaboration with the National Institutes of Health, the Company is also exploring TRV045 as a potential
- Verily links up with Sosei Heptares for GPCR drug discovery
receptors’ star has been on the rise in biotech in recent years as researchers have discovered the vast potential which have struck a research agreement to discover new GPCR targets that’ll fuel the development of potential
- Novo Nordisk moves to strengthen obesity efforts
EraCal has confirmed that the duo will utilise its phenotypic drug discovery platform to identify potential
- Orion and Peptilogics are pursuing AI-driven drug discovery to explore new functional chemical ...
discovery to explore new functional chemical space and precision-engineer therapeutics with enhanced potency
- Targeted Therapies to Reduce Side Effects in Modern Drug Development
It is necessary for drugs to evaluated for potential toxicities and side effects, and these key factors must be deemed tolerable before investigators can assess drug potency.
- Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84
Although blockade of GPR84 may potentially prove effective also in diseases associated with inflammation