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244 items found for "Single-cell transcriptome"
- Ep 23 with Dr. Qing Fan
Fan is currently an associate professor of Pharmacology and Pathology and Cell Biology at Columbia University
- Ep 66 with Dr. Antony A. Boucard Jr
moved to Mexico City to establish himself as an independent investigator integrating the department of Cell as various alternatively spliced isoforms thus potentially resulting in differential modulation of cell
- Ep 83 with Dr. Jean-Philippe Pin
His studies led to new concepts in the GPCR field, such as the activation of cell surface receptors by
- Observational Study of Repeat Immunoadsorption (RIA) in Post-COVID ME/CFS Patients with Elevated ß2-Adrenergic Receptor Autoantibodies-An Interim Report
for a randomised controlled trial (RCT), including sham apheresis, and for an RCT combining IA with B-cell post-COVID syndrome Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach
Among the five somatostatin receptors, SST2 and SST3 are associated with apoptosis and cell cycle arrest Michel Afargan Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Ep 07 with Dr. Paul Insel
Investigation, Molecular Pharmacology, British Journal of Pharmacology, and American Journal of Physiology-Cell
- Ep 142 with Dr Claudia Stäubert
Our ultimate goal is to understand their role in immune cell function and cancer cell metabolism. " Dr Yamina suggested the possibility of using native cells with optimized media, but Claudia highlighted
- Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
Mathematical models of biochemical reaction networks are an important and emerging tool for the study of cell Edward C Stites Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Signaling by Neutrophil G Protein-Coupled Receptors that Regulate the Release of Superoxide Anions
human peripheral blood, the neutrophil granulocytes (neutrophils) are the most-abundant white blood cells protein-coupled receptors (GPCRs), are critical for the elimination of pathogens and inflammatory insults, as well transactivation Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Agonists of galanin subtype 2 receptor may prevent pancreatic cancer and agonists of angiotensin II type 2 receptor may prevent colorectal cancer
Stimulation of GAL2 receptor may modulate immune surveillance and inhibits PDAC via cell cycle inhibition , pancreas Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
Mechanistically, RGS16 restrained JNK/P38-mediated apoptosis in CRC cells through disrupting the recruitment , Fuao Cao Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- C5aR2 receptor: The genomic twin of the flamboyant C5aR1
classical G-protein-coupled receptor (GPCR), whereas C5aR2 is a nonclassical GPCR that tailors immune cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- Delivery of US28 by incoming HCMV particles rapidly attenuates Akt activity to suppress HCMV lytic replication in monocytes
a virally encoded G protein-coupled receptor (GPCR) that is essential for silent infections within cells Gary C Chan Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Ep 134 with Dr. Neil Grimsey
We have developed an array of fluorescent biosensors to map kinase activity in living cells and are exploring
- Session V | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
extracellular regions (ECRs) with nine cadherin repeats and a variety of adhesion domains which couple cell CELSRs regulate planar cell polarity, including the closure of the neural tube. Despite numerous cell and animal studies, molecular details on CELSR proteins are sparsely available, We assign the N-terminal CADH1-8 module as necessary for cell adhesion and we show the C-terminal CAHD9
- Ep 49 with Dr. Sudha Shenoy
Sudha Shenoy is currently an Associate Professor in Medicine & Cell Biology in the Division of Cardiovascular
- Using food perception and bioamine signaling networks to slow aging
research in his laboratory focuses on how organisms perceive and respond to environmental stress though cell
- Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation
Transcriptomic analysis of Ltb4r2-/- and WT macrophages suggested a role for BLT2 in macrophage migration zebrafish Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- S1P Signaling Genes as Prominent Drivers of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia
Through comprehensive transcriptomic analysis of IM-sensitive and IM-resistant CML groups, we identified , leukemia Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model
tissue-damage-associated inflammation that epigenetically recruits, activates and orchestrates stem cells , Mutation Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Ep 13 with Dr. Amynah Pradhan
Amynah did her undergrad research measuring IP3 in airway smooth muscle cells and completed a Ph.D. at
- Spliceosome mutations are associated with clinical response in a phase 1b/2 study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia
Bone marrow (BM) samples were collected at baseline for genomic and transcriptomic analysis (n = 32). , Splicing Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Ep 59 with Dr. Nicola J. Smith
team has made advances in the understanding of how an orphan GPCR exerts its effects both in vitro (cell expertise to establish a research program that takes orphan GPCRs from ‘locked’, inaccessible receptors to well-characterized
- Ep 73 with Dr. Aylin Hanyaloglu
Her research focuses on understanding the fundamental cell biological mechanisms regulating GPCR activity
- Classified News | Dr. GPCR Ecosystem
Adhesion GPCRs September 25, 2024 The G Protein-Coupled Receptor GPR56 Is an Inhibitory Checkpoint for NK Cell BRET-Based Sensors Shed Light on Cellular Signaling Read More Read more articles from our Contributors Call
- DANGER Signals Activate G-Protein Receptor Kinases Suppressing Neutrophil Function and Predisposing to Infection After Tissue Trauma
Predicted rescue therapies were assessed in cell systems and mouse injury-dependent pneumonia models. Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- Ep 56 with Dr. Adriano Marchese
to reveal the spatial and temporal requirements for GPCR activation of signaling pathways related to cell
- Ep 15 with Dr. Arun Shukla
Jawaharlal Nehru University in India and it was during a biochemistry class where he learned about cell