For example, chemotherapy, a powerful standard approach to kill fast-growing cancer cells, has the drawback

We first synthesized a fluorescent ligand enabling equilibrium and kinetic binding studies via NanoBRET

development, PGE2 signaling regulates embryogenesis, hepatocyte differentiation, hematopoiesis, and kidney

We show that locally restricted suppression of postsynaptic cAMP levels or of cAMP-dependent protein-kinase

downstream signaling effectors along the Gαq/Phospholipase C (PLC) pathway, which results in an IkB kinases

system.SIGNIFICANCE STATEMENTIn C. elegans, axon regeneration is positively regulated by the EGL-30 Gqα-JNK MAP kinase

Here, we compared the efficacy of seven agonists to induce G protein, G protein-coupled receptor kinase

Acute Myocardial Infarction by Activating β-Arrestin-2, Protein Phosphatase 2A, and Glycogen Synthase Kinase They also showed higher protein levels of phospho-glycogen synthase kinase-3β (p-GSK3β), as well as total

with cell surface membrane proteins such as G-protein coupled receptors (GPCRs) and receptor tyrosine kinases

The drugs also target relatively low-hanging fruit: like cytokines or tyrosine kinase receptors.