in neurons and is responsible for binding to the t-SNARE complex, a group of proteins found on the target t-SNARE complex is composed of two different proteins: syntaxin and SNAP-25; syntaxin is found on the target form the SNARE complex, which is essential for the fusion of the synaptic vesicle membrane with the target

GPCRs in Oncology and Immunology G Protein-coupled Receptor-mediated Membrane Targeting of PLCγ2 is Essential Industry News A Current View of Allosteric GPCR Drug Discovery from the 2nd Annual GPCRs-Targeted Drug July 2 - 7, 2023). 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Jobs NEW Director - Targeted

conservation across distant species Industry News Avantor's (AVTR) New Offerings to Aid Cell and Gene Therapy and Exhibition NEW February 11 - 14, 2023 | 2024 BPS Annual Meeting March 5 - 7, 2024 | 3rd GPCRs - Targeted

receptor function, impacting synaptic transmission Orphan receptor GPR88 as a potential therapeutic target concentrations in Caenorhabditis elegans Comparison of infectious complications with BCMA-directed therapies

GPR84 has been shown to be an attractive target in pro‐inflammatory conditions (Gagnon et al., 2018; GPR84 overexpression in immune cells in a range of pro‐inflammatory disorders renders it a promising target Overall, GPR84 is a promising target to exploit and the investment in better tools to study its function

structural dynamics approach for identification of potential agonists of FFAR4 for type 2 diabetes mellitus therapy February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition March 5 - 7, 2024 | 3rd GPCRs - Targeted

GPCR Partnered Events March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit  We're partnering again with the 3rd GPCRs - Targeted Drug Discovery Summit in Boston on March 5-7, 2024. Hepatic Regulator of G protein Signaling 14 Ameliorates NAFLD through Activating cAMP-AMPK Signaling by Targeting

Interface between Health and Disease GPCRs arguably represent the most effective current therapeutic targets Given the tremendous success of GPCRs as therapeutic targets, considerable focus has been placed on the

Small-molecule targeting of GPCR-independent non-canonical G protein signaling inhibits cancer progression Cell-trafficking impairment in disease-associated LPA6 missense mutants and a potential pharmacoperone therapy

Industry News Septerna Secures $150 Million in Series B Financing to Advance Pipeline of Novel GPCR-targeted NEW Discovery On Target (September 25 - 28, 2023) 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27,

a typical G protein-coupled receptor, β-adrenergic-like octopamine receptor (Octβ2R), is the unique target

receptors (ORs) represent one of the most significant groups of G-protein coupled receptor (GPCR) drug targets

biomedical sciences with the mechanistic understanding of one of the biggest classes of pharmaceutical targets

Therapeutics , a biopharmaceutical company specializing in the research and development of innovative drugs targeting

stage international biopharmaceutical company with an innovative approach to drug discovery based on targeting

Proof-of-Concept Data From Phase 2a Clinical Study Neurocrine opening two Phase 1 trials in oral Parkinson’s therapies Conference and Exhibition February 11 - 14, 2024 | 2024 BPS Annual Meeting March 5 - 7, 2024 | 3rd GPCRs - Targeted

GPCRs in Neuroscience Conformationally Selective 2-Aminotetralin Ligands Targeting the alpha2A- and alpha2C-Adrenergic Scientist- Technology Tissue Culture Scientist/Tissue Culture Manager Postdoctoral Researcher Director - Targeted

understanding advanced molecular pharmacology such as functional selectivity, and clinical evaluation of CB2-targeting

enables cholesterol-dependent activation of the master growth regulator, the protein kinase mechanistic target

transmembrane signaling proteins that participate in many vital physiological functions making them a popular target

understanding advanced molecular pharmacology such as functional selectivity, and clinical evaluation of CB2-targeting

GPCRs in Neuroscience CGRP physiology, pharmacology, and therapeutic targets: Migraine and beyond. Targeted inhibition of the GRK2/HIF-1α pathway is an effective strategy to alleviate synovial hypoxia GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston.

trial will test the pharmacokinetics and safety profile of Inversago’s lead molecule, INV-202, on a targeted

elucidating the metabolic pathways involved in metabolic dysfunction and in developing new drugs as specific targets

adrenergic receptor in oral squamous cell carcinoma: an emerging prognostic indicator and future therapeutic target

Accordingly, from the information provided, it is plausible that specific PLC isozymes could be targeted

Finally, we briefly discuss the therapeutic targeting of vGPCRs as future treatment of acute and chronic

Cross-Functional Scientific and Drug Discovery Advisory Board Sosei Heptares and Lilly Enter Multi-target GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston.