Search Results
279 items found for "Tatiana Da Ros"
- Co-activation of GPCRs facilitate GIRK-dependent current
This study reports robust bidirectional interactions between these two converging receptor pathways.
- G protein-coupled receptor signaling: transducers and effectors
We will first summarize their prominent roles in GPCR pharmacology before transitioning into less well-explored
- Cholesterol-Dependent Dynamics of the Serotonin1A Receptor Utilizing Single Particle Tracking: ...
To explore the role of cholesterol in lateral dynamics of GPCRs, we utilized single particle tracking
- The regulation of PKA signaling in obesity and in the maintenance of metabolic health
Mouse models have provided invaluable information on the roles for PKA subunits in brain and key metabolic
- G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease..
The changes in amyloid pathology are accompanied by robust microglial and astrocytic hypertrophy, which
- N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 ...
towards more GLP-1 receptor interaction "Background and purpose: To fully elucidate the regulatory role
- Adrenal G Protein-Coupled Receptors and the Failing Heart: A Long-distance, Yet Intimate Affair
The adrenal gland plays an important role in the modulation of cardiac neurohormonal stress because it Particular emphasis is given to findings from the past decade and a half that highlight the emerging roles
- GB83, an Agonist of PAR2 with a Unique Mechanism of Action Distinct from Trypsin and PAR2-AP
misconceived as antagonists, and this has impeded a better understanding of the pathophysiological role mediated cellular signaling and is a useful pharmacological tool for studying the pathophysiological role
- The complicated lives of GPCRs in cardiac fibroblasts
October 2022 "The role of different G protein-coupled receptors (GPCRs) in the cardiovascular system
- Differences across sexes on head-twitch behavior and 5-HT2A receptor signaling in C57BL/6J mice
Much of the understanding of psychedelic pharmacology is derived from rodent models, but most of this
- The Adhesion GPCR VLGR1/ADGRV1 Regulates the Ca2+ Homeostasis at Mitochondria-Associated ER Membrane
the molecular and functional interaction of VLGR1 with components in MAMs and point to an essential role
- Comparative study of neuropeptide signaling systems in Hemiptera
Their expression profiles at the probe and feeding stages reflected potential regulatory roles in probe
- Mechanistic Understanding of the Palmitoylation of Go Protein in the Allosteric Regulation of...
Receptor GPR97 "Adhesion G-protein-coupled receptors (aGPCRs)-a major family of GPCRs-play critical roles
- Diversification of PAR signaling through receptor crosstalk
explored and represents a novel mechanism providing diversity to receptor function and play important roles
- PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design
October 2022 "While the role of G-protein-coupled receptors (GPCR) in cancer is acknowledged, their underlying
- Single-molecule counting applied to the study of GPCR oligomerization
While early evidence for the role of oligomerization in receptor signaling came from ensemble biochemical microscopy-with a particular emphasis on the potential for these techniques to advance our understanding of the role
- Activation of GPR183 by 7 α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through...
In rodents, intrathecal injection of its ligand, 7α,25-dihydroxycholesterol (7α,25-OHC), causes time-dependent
- Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses
We discuss ligand binding, signaling, and structures of the vGPCRs in light of robust differences from
- Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi...
with the fungal surface, leading to opsonization and release of small peptide fragments such as C3a, a role insight into host processes that affect Hc-macrophage interactions and uncover a novel and specific role
- GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the...
Our results suggest that GPR15/GPR15L have a pathogenic role in RA and their antagonizing could be a
- Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable to...
To this end, we comprehensively analyzed the potential role of ADGRA1 in the neurobehaviors of mice by Together, our findings reveal an important suppressive role of ADGRA1 in anxiety control and synaptic
- Intermolecular Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Interface
Although ligand-lipid interactions are weak, lipid tails play a role in ligand binding pose stability
- Nanobodies as Probes and Modulators of Cardiovascular G Protein-Coupled Receptors
is of paramount importance to the field of cardiovascular medicine due to the critical physiological roles
- High hedgehog signaling is transduced by a multikinase-dependent switch controlling the...
GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role
- Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or sy
Methods: Using a widely adopted rodent model of 3-day recurrent hypoglycemia, we first checked expression
- Allosteric modulation of GPCRs: From structural insights to in silico drug discovery
October 2022 "G protein-coupled receptors (GPCRs) play critical roles in human physiology and are one
- Although the cannabinoid type-2 receptor (CB2) is highly expressed in the immune system, emerging...
receptor (CB2) is highly expressed in the immune system, emerging evidence points to CB2 playing a key role
- Molecular targets of psychedelic-induced plasticity
Considering the central role of the serotonin 5-HT2A receptor in the distinct effects of psychedelics