Search Results
244 results found for "Tectonic Therapeutic"
- Crinetics Pharmaceuticals Expands Executive Team With Appointment Of James Hassard As Chief ...
stage pharmaceutical company focused on the discovery, development, and commercialization of novel therapeutics
- Activation of the human chemokine receptor CX3CR1 regulated by cholesterol
receptor subfamily, CX3CR1 binds to its sole endogenous ligand CX3CL1, which shows notable potential as a therapeutic
- Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery
In summary, targeting GPCR-activated ERK pathways represents a promising strategy for developing new therapeutics ERK-dependent apoptosis as a potential therapeutic strategy for cancer. Cells, 10(10), 2509.
- 📰 GPCR Weekly News, March 27 to April 4, 2023
Therapeutic potential of opioid receptor heteromers in chronic pain and associated comorbidities. Industry News Confo Therapeutics Enters into Collaboration Agreement with Daiichi Sankyo to Discover SMILES-based de novo molecular generation with curriculum and deep reinforcement learning Structure Therapeutics
- Isoform-and ligand-specific modulation of adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder
using unique tools, and thus establishes a foundation for the development of fine-tuned aGPCR-targeted therapeutics
- 📰 GPCR Weekly News, May 22 to 28, 2023
Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief. Patients with Idiopathic Pulmonary Fibrosis Exscientia Business Update for First Quarter 2023 Structure Therapeutics
- 📰 GPCR Weekly News, July 17 to July 23, 2023
GPCR Symposium on GPCRs as Therapeutic Modalities on September 22nd. Domain Therapeutics announces the European Patent Office decision to grant a patent for its proprietary
- From DNA day to GPCR genomics
GPCR-targeted drugs, and the exploration of GPCRs as key regulators of physiological processes and therapeutic analysis, have facilitated drug discovery and design targeting GPCRs, leading to the development of novel therapeutics
- Crinetics Pharmaceuticals Announces Pricing Of Underwritten Common Stock Offering
clinical-stage pharmaceutical company focused on the discovery, development and commercialization of novel therapeutics
- A central alarm system that gates multi-sensory innate threat cues to the amygdala
The identification of unified innate threat pathways may provide insights into developing therapeutic
- Nanobodies as Probes and Modulators of Cardiovascular G Protein-Coupled Receptors
nanobodies with tailored specificities may expand the impact of these tools for both basic science and therapeutic
- 📰 GPCR Weekly News, March 11 to 17, 2024
Insights into GPCR Function Time-resolved cryo-EM of G-protein activation by a GPCR Industry News Domain Therapeutics Protein Structures Newly discovered adhesion GPCR mayo controls midgut development in Drosophila Karuna Therapeutics
- 📰 GPCR Weekly News, January 30 to February 5, 2023
Non-canonical Golgi-compartmentalized Gβγ signaling: mechanisms, functions, and therapeutic targets. Announces First-in-Human Study for Bristol Myers Squibb In-Licensed PKC Theta Inhibitor, EXS4318 GPCR Therapeutics interest’ Addex Strategic Partner Completes Enrollment In Adx71149 Epilepsy Phase 2 Study Part 1 Domain Therapeutics
- Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5...
However, how these states impact GPCRs biological function and therapeutic targeting remains incompletely
- 📰 GPCR Weekly News, June 5 to 11, 2023
Novartis bolsters innovative medicines strategy and renal pipeline with agreement to acquire Chinook Therapeutics Confo Therapeutics Enters Into Research Collaboration For GPCR-Targeting Antibody Discovery With AbCellera
- 📰 GPCR Weekly News, January 16 to 22, 2023
Industry News Addex Provides Corporate Update And Financial Guidance Structure Therapeutics Appoints Industry Leaders Eric Dobmeier and Joanne Waldstreicher to its Board of Directors GPCR Therapeutics launches
- Orion Shares New Data on its Latest Best-in-Class Drug Candidate
10, 2022 — Orion Biotechnology Canada Ltd, a drug discovery and development company unlocking the therapeutic
- Chronic itch: emerging treatments following new research concepts
itch processing, the numerous mediators and receptors involved has led to a large variety of possible therapeutic
- 📰 GPCR Weekly News, February 26 to March 3, 2024
and drug discovery in endocrinology and metabolism Reviews, GPCRs, and more Butyrate as a promising therapeutic cadherin G protein-coupled receptors that bind cry toxins of Bacillus thuringiensis Industry News Domain Therapeutics
- Orion Announces The Rapid Lead Optimization Of Ob-004 - A Ccr2 Antagonist
Ottawa, Ontario, Canada, Nov. 30, 2021 -- Orion Biotechnology, a clinical stage company unlocking the therapeutic
- Harnessing Deep Mutational Scanning for Enhanced Drug Discovery
development of more personalised therapies tailored to the genetic makeup of individual patients, enhancing therapeutic that can drive the early stages of target and lead identification, combat drug resistance, and refine therapeutic
- Immunomodulatory Role of Neuropeptides in the Cornea
maintaining the homeostasis of the ocular surface, alterations in disease settings, and the possible therapeutic
- Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...
Understanding these processes has important implications for understanding the therapeutic intervention
- 📰 GPCR Weekly News, February 6 to 12, 2023
IPO, raising $161M 3-drug combo leads to 'unprecedented' response in pancreatic cancer models Addex Therapeutics in ADX71149 Epilepsy Phase 2 Study Part 1 IPO Raises $161M for GPCR-Based Drug Developer Structure Therapeutics
- APEX2/AUR Biosensor: A Powerful Tool for Protein Interaction and Trafficking
; understanding the role of DNAJC13 in GPCR trafficking could profoundly affect the development of therapeutic
- An overview of the compartmentalized GPCR Signaling: Relevance and Implications
compartments and signaling pathways associated with GPCRs holds promise for the development of novel therapeutic Insights into Nuclear G-Protein-Coupled Receptors as Therapeutic Targets in Non-Communicable Diseases GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic
- Lipid Modulation of a Class B GPCR: Elucidating the Modulatory Role of PI(4,5)P 2 Lipids
interacting with the Glucagon receptor (GCGR), which constitutes an important target for diabetes and obesity therapeutics
- TRPM3 in the eye and in the nervous system - from new findings to novel mechanisms
clear picture is needed to unravel TRPM3's full potential as experimental tool, diagnostic marker and therapeutic