Search Results

This review focuses on the vGPCRs encoded by the human β- and γ-herpesviruses. These include receptors from human cytomegalovirus, which encodes four vGPCRs: US27, US28, UL33, and UL78; human herpesvirus 6 and 7 with two receptors: U12 and U51; Epstein-Barr virus with one: BILF1;

Current studies focused on the potentially clinical effects of psychedelics on human subjects tend to Here we tested the effects of DOI on head-twitch behavior (HTR) - a mouse behavioral proxy of human psychedelic

Chronic human HF is characterized by several important neurohormonal perturbations, emanating from both

Mutations in VLGR1 have been associated with the human Usher syndrome (USH), the most common form of

Among them, the secretin/adhesion (Class B) G protein-coupled receptors are essential drug targets for human

Searching for antagonist activity, we performed systematic N-terminal truncations of human GLP-2(1-33 Experimental approach: COS-7 cells were transfected with the human GLP-2R and assessed for cAMP accumulation To examine selectivity, COS-7 cells expressing human GLP-1 or GIP receptors were assessed for cAMP accumulation

October 2022 "The prefrontal cortex (PFC) is a hub for cognitive control, and dopamine profoundly influences

further highlight residues in transmembrane 7 (TM7) that mediate stronger signaling in mouse versus human

and stable recombinant protein constructs GST-CB1414-472 and GST-CB1414-442 containing much of the human the C-terminal residues 443-473 of the mouse CB1 receptor that corresponds to residues 442-472 in the human

Single Particle Tracking: Analysis of Diffusion Modes "G protein-coupled receptors (GPCRs) are signaling hubs

compounds with therapeutic potential that have even been used safely in phase 1 and 2 clinical trials in human

While limited, human studies infer differential regulation of the PKA system in obese compared to lean

GPCR Virtual Cafe with Matthew Eddy scheduled for tomorrow (Sep 29th, 2022) due to Hurricane Ian that

Considering the central role of the serotonin 5-HT2A receptor in the distinct effects of psychedelics in human Here we discuss some of the most recent findings in human studies and contextualize them considering

The adenosine A1 and A2A receptors are expressed in the human brain and have a proposed involvement in

summarizes the ongoing and future research for targeting this critical kinase across cellular, animal and human

The aim of this study was to evaluate the role of GPR21 in human macrophages, analyzing (i) its involvement Boyden chamber migration assay, performed on macrophages derived from both the THP-1 cell line and human

chemokine receptor 5 (CCR5), a major receptor in inflammation and the principal entry co-receptor for Human

mechanism involving interaction between neurotrophic factor-α1 (NF-α1/carboxypeptidase E, CPE) and human Immunofluorescence studies showed 5-HTR1E and NF-α1/CPE are highly expressed and co-localized on cell surface of human Importantly, knock-down of 5-HTR1E in human primary neurons diminished the NF-α1/CPE-mediated protection

GRK2 was shown to be expressed in human neutrophils and analysis of subcellular fractions revealed a

Do you hustle around looking for information about your favorite #GPCR? No need for that anymore!

involved in the regulation of the internalization, mitochondria-targeting and -activating properties of human salivary histatin 1 "Human salivary histatin 1 (Hst1) exhibits a series of cell-activating properties

proposed a direct effect of follicle-stimulating hormone (FSH) on the skeletal metabolism, but results of human

In this article, we describe a 2.2 Å resolution room temperature crystal structure of the human S1P5

modify receptor-transducer coupling and mediate intracellular pathway bias "Within the intestine, the human

It plays a key role in the regulation of human calcium and thus mineral metabolism.

Regulatory autoantibodies (abs) are discussed, which are parts of the human physiology and are specifically

conducted to elucidate binding mechanisms of a middle-sized flexible molecule, bosentan, to a GPCR protein, human