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glutamate residue at position 3.45, which is not found in human class A GPCRs, and it does not have an acidic

Previously, we had identified a novel pyrazole-based agonist 1 ((S)-N-(1-(cyclobutylamino)-1-oxo-5-(piperidin

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These differences impeded the use of predicted structure models in the functional study and structure-based

Identification of a potential structure-based GPCR drug for interstitial cystitis/bladder pain syndrome Non-ionic cholesterol-based additives for the stabilization of membrane proteins. Evaluating GPCR modeling and docking strategies in the era of deep learning-based protein structure prediction

Therapeutics (SIX and Nasdaq: ADXN), a clinical-stage pharmaceutical company pioneering allosteric modulation-based

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synthesize, degrade, and respond to cannabinoids which has implications for the development of cannabinoid-based

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This approach can expand the repertoire of adenosine receptor antagonists that can be designed based

Furthermore, the utilisation of advanced NanoLuc/FlAsH-based biosensors reveals distinct conformational

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This article focussed on emerging fields based on the authors’ current work and expertise.

Great success has been reached with therapies based on the GLP-1 receptor monoagonism; therefore, a logical

Heteroptera and Auchenorrhyncha, which was consistent with Sternorrhyncha's phylogenetic position at the base

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schizophrenia-relevant circuits, where the physiological consequence of CB2 receptor activation could correct circuit-based

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Gq/11 signaling of chimeric receptors was analyzed using luciferase-based reporter gene (NFAT) assays

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