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247 items found for "cell polarity"
- Biochemical pharmacology of adenylyl cyclases in cancer
The precise mechanisms by which ACs contribute to cancer cell proliferation and invasion are not well Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus
Group 2 innate lymphoid cells (ILC2s) play a critical role in maintaining adipose homeostasis via the resistance Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Ep 66 with Dr. Antony A. Boucard Jr
moved to Mexico City to establish himself as an independent investigator integrating the department of Cell as various alternatively spliced isoforms thus potentially resulting in differential modulation of cell
- Ep 07 with Dr. Paul Insel
Investigation, Molecular Pharmacology, British Journal of Pharmacology, and American Journal of Physiology-Cell
- Observational Study of Repeat Immunoadsorption (RIA) in Post-COVID ME/CFS Patients with Elevated ß2-Adrenergic Receptor Autoantibodies-An Interim Report
for a randomised controlled trial (RCT), including sham apheresis, and for an RCT combining IA with B-cell post-COVID syndrome Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach
Among the five somatostatin receptors, SST2 and SST3 are associated with apoptosis and cell cycle arrest Michel Afargan Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma
transcriptomic, proteomic, and phosphoproteomic differential expression data of GPR56 knockdown U373-GBM cells Signaling , TG2 Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Neutrophils are itching to specialize
February 13, 2024 Abstract "Neutrophils are heterogeneous, but the mechanisms underlying their ability to polarize the GPCR Mrgpra1 and the neuropeptide NPFF, molecules involved in pain and itch, direct neutrophil polarization Bryan G Yipp Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Ep 134 with Dr. Neil Grimsey
We have developed an array of fluorescent biosensors to map kinase activity in living cells and are exploring
- Ep 142 with Dr Claudia Stäubert
Our ultimate goal is to understand their role in immune cell function and cancer cell metabolism. " Dr Yamina suggested the possibility of using native cells with optimized media, but Claudia highlighted
- Ascitic Shear Stress Activates GPCRs and Downregulates Mucin 15 to Promote OvarianCancer Malignancy
circulating ascites, the mechanisms that initiate these currents and subsequent fluid shear stresses are not well We show that ovarian cancer cells exposed to ascitic shear stresses display heightened G protein-coupled Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News GPCR Jobs Call
- Ep 49 with Dr. Sudha Shenoy
Sudha Shenoy is currently an Associate Professor in Medicine & Cell Biology in the Division of Cardiovascular
- Using food perception and bioamine signaling networks to slow aging
research in his laboratory focuses on how organisms perceive and respond to environmental stress though cell
- Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
Mechanistically, RGS16 restrained JNK/P38-mediated apoptosis in CRC cells through disrupting the recruitment , Fuao Cao Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Delivery of US28 by incoming HCMV particles rapidly attenuates Akt activity to suppress HCMV lytic replication in monocytes
a virally encoded G protein-coupled receptor (GPCR) that is essential for silent infections within cells Gary C Chan Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
Mathematical models of biochemical reaction networks are an important and emerging tool for the study of cell Edward C Stites Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Agonists of galanin subtype 2 receptor may prevent pancreatic cancer and agonists of angiotensin II type 2 receptor may prevent colorectal cancer
Stimulation of GAL2 receptor may modulate immune surveillance and inhibits PDAC via cell cycle inhibition , pancreas Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- C5aR2 receptor: The genomic twin of the flamboyant C5aR1
classical G-protein-coupled receptor (GPCR), whereas C5aR2 is a nonclassical GPCR that tailors immune cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- Signaling by Neutrophil G Protein-Coupled Receptors that Regulate the Release of Superoxide Anions
human peripheral blood, the neutrophil granulocytes (neutrophils) are the most-abundant white blood cells protein-coupled receptors (GPCRs), are critical for the elimination of pathogens and inflammatory insults, as well transactivation Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Ep 50 with Dr. Thomas P. Sakmar
learned gene synthesis, cDNA cloning, site-directed mutagenesis, and heterologous expression in mammalian cells suppression method to genetically encode unnatural amino acids into membrane proteins expressed in mammalian cell
- Ep 13 with Dr. Amynah Pradhan
Amynah did her undergrad research measuring IP3 in airway smooth muscle cells and completed a Ph.D. at
- The Effect of Cancer-Associated Mutations on Ligand Binding and Receptor Function - A Case for the 5-HT2C Receptor
Such mutations may affect serotonin-mediated signaling in tumor cells as well as treatment strategies serotonin Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model
tissue-damage-associated inflammation that epigenetically recruits, activates and orchestrates stem cells , Mutation Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Ep 73 with Dr. Aylin Hanyaloglu
Her research focuses on understanding the fundamental cell biological mechanisms regulating GPCR activity
- Ep 59 with Dr. Nicola J. Smith
team has made advances in the understanding of how an orphan GPCR exerts its effects both in vitro (cell expertise to establish a research program that takes orphan GPCRs from ‘locked’, inaccessible receptors to well-characterized
- Flash News / DrGPCR
so&utm_medium=mail&cid=79a6b35e-7ba6-44a0-863b-0842f5a5cfd3 #gpcr #drgpcr #bittertaste Dec 4, 2024 A well-updated www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/latrophilin-2-deletion-in-cardiomyocyte-disrupts-cell-junction receptor-activation-and-signaling/germline-mutations-in-a-g-protein-identify-signaling-cross-talk-in-t-cells gpcr #drgpcr Oct 24, 2024 New biosensor technologies are shedding light on GPCR dynamics directly in cells
- Ep 15 with Dr. Arun Shukla
Jawaharlal Nehru University in India and it was during a biochemistry class where he learned about cell
- Ep 136 with Murat Tunaboylu & Ben Holland
After switching to biotech, Murat has built cell imaging software and lab robots to accelerate cancer